3 results for "Li-Na Lin"

Identification and Functional Analysis of Variant Haplotypes in the 5′-Flanking Region of Protein Phosphatase 2A-Bδ Gene

Hui-Feng Chen; Li-Na Lin; Yu-Xi Chen et al.

PLoS ONE, Vol. 7 No. 4 · 2012 · English · PLOS Scopus

Serine-threonine protein phosphatase 2A (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of cell growth, differentiation, and apoptosis. The substrate specificity and (sub)cellular localization of the PP2A holoenzymes are highly regulated by interaction with a family of…

Role of a Novel Functional Variant in the PPP2R1A Promoter on the Regulation of PP2A-Aalpha and the Risk of Hepatocellular Carcinoma

Hui-Feng Chen; Jian-Rong Mai; Jian-Xin Wan et al.

PLoS ONE, Vol. 8 No. 3 · 2013 · English · PLOS Scopus

Previously, we identified the genetic variant −241 (−/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may…

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