40 results for "XU Li-jun"
Showing 1–20 · 2.27 seconds · RSS
-
Journal Article Full text
Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients
AIM: To observe the findings of spectral domain optical coherence tomography (SD-OCT) scan in cytomegalovirus retinitis (CMVR). METHODS: Forty-six eyes of 33 patients with acquired immunodeficiency syndrome and CMVR were enrolled in the study. Complete ophthalmologic examinations, color fundus…
-
Journal Article Full text
Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells
AIM: Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of insulin resistance and pancreatic β-cell dysfunction. The aim of this study is to investigate whether the insulin-sensitizing action of berberine is related to reducing ER stress. METHODS: ER stress in cultured…
-
Journal Article Full text
Blood Pressure and the Risk of Alzheimer’s Disease
Alzheimer disease is one of the most common neurodegenerative disorder, and the incidence is increasing. Many epidemiologic studies have considered the association between blood pressure and Alzheimer disease, yet the relationship is still controversial. The objective of this study was to validate…
-
Journal Article Full text
Selective Dysfunction of Hippocampal CA1 Astrocytes Contributes to Delayed Neuronal Damage after Transient Forebrain Ischemia
Transient global ischemia, as with cardiac arrest, causes loss of CA1 hippocampal neurons 2–4 d later, whereas nearby dentate gyrus (DG) neurons are relatively resistant. Whether differential astrocyte vulnerability in ischemic injury contributes to CA1 neuronal death is uncertain. Here, we find…
-
Journal Article Full text
Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress
Wild-type inducible Hsp70 (WT) and 2 folding deficient mutants protect the brain against focal cerebral ischemia in vivo and brain cells from oxygen–glucose deprivation (OGD) in vitro, but the protective mechanisms remain unclear. Mitochondria are central to both normal physiological function and…
-
Journal Article Full text
Grb2-associated binder-2 gene promotes migration of non-small cell lung cancer cells via Akt signaling pathway
Early stages of non-small cell lung cancer (NSCLC) can be successfully treated by surgical resection of the tumor, but there is still no effective treatment once it is progressed to metastatic phases. Investigation of NSCLC cancer cell migration, metastasis and development of strategies to block…
-
Journal Article Full text
Different Subsets of Macrophages in Patients with New Onset Tuberculous Pleural Effusion
OBJECTIVE: Macrophages are the infiltrate components of tuberculous pleural effusion (TPE). This study is aimed at examining the role of different subsets of macrophages in pleural fluid (PF) and peripheral blood (PB) from patients with new onset TPE. METHODS: The numbers of PB and PF CD163(+)…
-
Journal Article Full text
Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia
MiR-181 has deleterious effects on stroke outcome, and reducing miR-181a levels prior to middle cerebral artery occlusion (MCAO) was shown previously to be protective. Here we tested the effect of post-ischemic treatment with miR-181a antagomir by intracerebroventricular and intravenous routes of…
-
Journal Article Full text
Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKβ
AIM: To investigate the effects and molecular mechanisms of berberine on improving insulin resistance induced by free fatty acids (FFAs) in 3T3-L1 adipocytes. METHODS: The model of insulin resistance in 3T3-L1 adipocytes was established by adding palmic acid (0.5 mmol/L) to the culture medium…
-
Journal Article Full text
Overexpressing GRP78 influences Ca(2+) handling and function of mitochondria in astrocytes after ischemia-like stress
Ca(2+) transfer from endoplasmic reticulum (ER) to mitochondria at contact sites between the organelles can induce mitochondrial dysfunction and programmed cell death after stress. The ER-localized chaperone glucose-regulated protein 78 kDa (GRP78/BiP) protects neurons against excitotoxicity and…
-
Journal Article Full text
Bis(2,2′-bi-1H-imidazole-κ(2) N (3),N (3′))bis(dimethyl sulfoxide-κO)copper(II) bis(tetrafluoridoborate)
In the title copper(II) salt, [Cu(C(6)H(6)N(4))(2)(C(2)H(6)OS)(2)](BF(4))(2), the Jahn–Teller distorted octahedral coordination sphere of copper is formed from four 2,2′-bi-1H-imidazole N atoms and two dimethyl sulfoxide O atoms. The Cu atom lies on a center of inversion. N—H⋯O and N—H⋯F hydrogen…
-
Journal Article Full text
Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw
AIM: To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by high caloric laboratory chaw. METHODS: Non-alcoholic fatty liver model was successfully established by feeding with high caloric laboratory chaw for 12 wk. Then the model rats were randomly…
-
Journal Article Full text
CD4(+)CD25(−)Foxp3(+) T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax
BACKGROUND: Foxp3(+) T cells regulate inflammation and tumorigenesis. However, little is known about the role of different subsets of Foxp3(+) T cells in malignant or tuberculous hydrothorax. METHODS: The numbers of CD4(+)CD25(+)Foxp3(+), CD4(+)CD25(−)Foxp3(+) T cells and the levels of some…
-
Journal Article Full text
A tensor product quasi-Poisson model for estimating health effects of multiple ambient pollutants on mortality
BACKGROUND: People are exposed to mixtures of highly correlated gaseous, liquid and solid pollutants. However, in previous studies, the assessment of air pollution effects was mainly based on single-pollutant models or was simultaneously included as multiple pollutants in a model. It is essential…
-
Journal Article Full text
Long-term study on the osteogenetic capability and mechanical behavior of a new resorbable biocomposite anchor in a canine model
BACKGROUND: Biodegradable suture anchors are commonly used for repairing torn rotator cuffs, but these biodegradable materials still suffer from low mechanical strength, poor osteointegration, and the generation of acidic degradation byproducts. METHOD: The purpose of this study was to evaluate the…
-
Journal Article Full text
Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α
BACKGROUND: Gastric cancer is the third deadliest cancer in the world and ranks second in incidence and mortality of cancers in China. Despite advances in prevention, diagnosis, and therapy, the absolute number of cases is increasing every year due to aging and the growth of high-risk populations…
-
Journal Article Full text
New role for ceramide in hypoxia and insulin resistance
Ceramides are significant metabolic products of sphingolipids in lipid metabolism and are associated with insulin resistance and hepatic steatosis. In chronic inflammatory pathological conditions, hypoxia occurs, the metabolism of ceramide changes, and insulin resistance arises. Hypoxia-inducible…
-
Journal Article Full text
Base-iodine-promoted metal-catalyst-free reactions of [60]fullerene with β-keto esters for the selective formation of [60]fullerene derivatives
In this study, methanofullerenes and 2′,3′-dihydrofuran C(60) derivatives were selectively synthesized in high yields via the reactions of C(60) with β-keto esters under mild conditions by controlling the addition sequence and molar ratio of iodine and base. The structures of the products were…
-
Journal Article Full text
Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition
Major progress has been made clinically in inhibiting the programmed death receptor 1 (PD-1)/PD-L1 interaction to enhance T cell-mediated immune function, yet the effectiveness of anti-PD-L1/PD-1 agents in enhancing natural killer (NK) cell’s function remains largely unknown. Susceptibilities of…
-
Journal Article Full text
Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems
The aim of this study was to assess the underlying impact of Tetramethylpyrazine (TMP), which is the main activity compound of Ligusticum chuanxiong Hort, on the blood–brain barrier, inflammatory and nitrous oxide systems in a rat model of lipopolysaccharide (LPS)-induced sepsis. The SD rats were…