88 results for "LI Tianshu"
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Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency
Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway. In this study, K3C16, a…
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Microscopic Mechanism and Kinetics of Ice Formation at Complex Interfaces: Zooming in on Kaolinite
[Image: see text] Most ice in nature forms because of impurities which boost the exceedingly low nucleation rate of pure supercooled water. However, the microscopic details of ice nucleation on these substances remain largely unknown. Here, we have unraveled the molecular mechanism and the kinetics…
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New Polymorphs of 2D Indium Selenide with Enhanced Electronic Properties
The 2D semiconductor indium selenide (InSe) has attracted significant interest due its unique electronic band structure, high electron mobility, and wide tunability of its band gap energy achieved by varying the layer thickness. All these features make 2D InSe a potential candidate for advanced…
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The Impact of Low-Level Viraemia on Virological Failure—Results From a Multicenter HIV Antiretroviral Therapy Cohort Study in Yunnan, China
BACKGROUND: HIV viral load (VL) is an important indicator to monitor treatment response in antiretroviral therapy (ART). Patients on ART may experience viral blips, with low-level elevations of VL between 50 and 999 copies/mL known as low-level viraemia (LLV), but not reaching the threshold for…
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Prevalence of sufficient physical activity among general adult population and sub-populations with chronic conditions or disability in the USA
BACKGROUND: Recently, the World Health Organization (WHO) released an updated global guideline on physical activity and sedentary behavior, including recommendations for sub-populations living with chronic conditions or disabilities. We aimed to examine the prevalence of meeting the WHO…
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Linear association of compound dietary antioxidant index with hyperlipidemia: a cross-sectional study
BACKGROUND: There is growing evidence that antioxidant-rich diets may prevent hyperlipidemia. However, the relationship between the Composite Dietary Antioxidant Index (CDAI) and hyperlipidemia is unclear. The CDAI is a composite score reflecting the antioxidant content of an individual’s diet, and…
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Association of visceral adiposity index with hypertension (NHANES 2003–2018)
OBJECTIVES: This study focused on the association between visceral adiposity index (VAI) and the prevalence of hypertension in a nationally representative population of American adults. METHODS: The study obtained data from the National Health and Nutrition Examination Survey (NHANES) database from…
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A multi-method analysis of employee-driven green service innovation in hotels based on the ability-motivation-opportunity framework
Against the backdrop of green transformation as a strategic priority in the hotel industry, the employee-driven mechanisms of green service innovation (GSI) remain insufficiently understood. Existing studies largely rely on linear pathways and fail to capture the complex interactions among ability…
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Effect of Fiber Surface Characteristics on the Interfacial Properties of T1100-Grade Carbon Fiber Bismaleimide Composites
To clarify the effect of surface characteristics on the interfacial properties of T1100-grade carbon fiber (CF)/bismaleimide (BMI) composites, three CFs (F1, F2, and F3) with different surface treatments and sizing agents were studied. Surface physicochemical properties and sizing–resin reaction…
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Protein-Decorated Reverse Osmosis Membranes with High Gypsum Scaling Resistance
[Image: see text] The global challenge of water scarcity has fueled significant interest in membrane desalination, particularly reverse osmosis (RO), for producing fresh water from various unconventional sources. However, mineral scaling remains a critical issue that compromises the membrane…
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A model of decentralized vision in the sea urchin Diadema africanum
Sea urchins can detect light and move in relation to luminous stimuli despite lacking eyes. They presumably detect light through photoreceptor cells distributed on their body surface. However, there is currently no mechanistic explanation of how these animals can process light to detect visual…
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Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a
The properties of stem cells can be induced during the epithelial to mesenchymal transition (EMT). The responsible molecular mechanisms, however, remain largely undefined. Here we report the identification of the microRNA-146a (miR-146a) as a common target of Krüppel-like factor 8 (KLF8) and TGF-β…
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Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation
Two lipid-based nanoformulations have been used to date in clinical studies: lipoplexes and lipid nanoparticles (LNPs). In this study, we prepared small interfering RNA (siRNA)-loaded carriers using lipid components of the same composition to form molecular assemblies of differing structures, and…
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Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes
Cerium oxide nanoparticles (nanoceria), well known for their pro- and antioxidant features, have been recently proposed for the treatment of several pathologies, including cancer and neurodegenerative diseases. However, interaction between nanoceria and biological molecules such as proteins and…
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Terahertz Enhanced Sensing of Uric Acid Based on Metallic Slot Array Metamaterial
An enzyme-free terahertz uric acid sensor based on a metallic slot array metamaterial was proposed and realized both theoretically and experimentally. The sensing model was verified in simulation and femtosecond laser processing technology was employed to ablate slots in the copper plate to…
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Repetitive transcranial magnetic stimulation impacts the executive function of patients with vascular cognitive impairment: a systematic review and meta-analysis
OBJECTIVE: Executive dysfunction is a core symptom of vascular cognitive impairment (VCI), which seriously affects patients’ prognosis. This paper aims to investigate the effectiveness of rTMS on executive function in VCI. METHODS: The databases selected for this study included Pubmed, Embase…
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Decreased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma
Background: Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor of the head and neck, the exact mechanism of which has not been explored. Methods: By analyzing the GEO data, we found the highly methylated and low expression gene ZNF671. The expression level of ZNF671 in clinical samples…
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Multiscale Interlaminar Enhancement of CNT Network/CF Hybrid Composites and In Situ Monitoring of Crack Propagation Behavior
It has long been desired to achieve mechanical enhancement and structural health monitoring by introducing carbon nanotubes (CNTs) into traditional carbon fiber (CF) composites. Herein, the initiation of micro-damage and crack propagation has been investigated by utilizing in situ electrical…
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From empathy to creative output: exploring the emotional–cognitive mechanisms of digital creativity
The rapid advancement of digital technologies has reshaped how creativity is fostered, especially in fields such as education, business, and the creative industries. However, the mechanisms behind digital creativity remain underexplored, particularly regarding the roles of emotional and cognitive…
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Investigation on the Demand for TCM "Preventive Treatment of Disease" Service in Community Elderly Care Facilities
Background The theoretical system and intervention technologies of TCM "preventive treatment of disease" service are mature, with certain economic and cultural advantages coping with health needs in different states. Providing TCM "preventive treatment of disease" service in community elderly care…