28 hasil untuk "Ruby Yu"

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Brian Rudolph Shy; Vivasvan S. Vykunta; Alvin S. Ha dkk.

Nature Biotechnology · 2022 · Inggris · OpenAlex

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

Ke, Xin-Yu; Chen, Ye; Tham, Valarie Yu-Yan dkk.

Oncogene · 2021 · Inggris · PubMed Central

Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcome of patients with advanced tumors especially de-differentiated liposarcoma and uterine leiomyosarcoma remains unsatisfactory, despite intensive treatment regimens including maximal surgical…

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma

Chen, Ye; Xu, Liang; Mayakonda, Anand dkk.

Nat Commun · 2019 · Inggris · PubMed Central

Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and transcriptional addiction in this disease, we chart super-enhancer structures in both LPS tissues and cell lines. We identify a bromodomain…

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Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma

Xu, Liang; Chen, Ye; Mayakonda, Anand dkk.

Proc Natl Acad Sci U S A · 2018 · Inggris · PubMed Central

Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers. However, the BET protein-dependent glioblastoma (GBM)-promoting transcriptional network remains elusive. Here, with mechanistic exploration…

Topography of transcriptionally active chromatin in glioblastoma

Xu, Liang; Chen, Ye; Huang, Yulun dkk.

Sci Adv · 2021 · Inggris · PubMed Central

Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylation, and genomic variations advances both cancer research and clinical diagnosis. The enhancer architectures and regulatory circuitries governing tumor-intrinsic transcriptional…

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Jeffrey D. Whitman; Joseph B Hiatt; Cody T. Mowery dkk.

Nature Biotechnology · 2020 · Inggris · OpenAlex

International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions

Grant R. Tomkinson; Justin J. Lang; Lukáš Rubín dkk.

Journal of Sport and Health Science, Vol. 14 · 2025 · Inggris · DOAJ Scopus

Background: Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability. Handgrip strength (HGS) using isometric dynamometry is a convenient, feasible, and widely used method of assessing muscular strength among people of all ages…