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Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates T H 2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation

Caio Cesar de Souza Alves; Adam Collison; Luke Hatchwell dkk.

PLoS ONE, Vol. 8 No. 11 · 2013 · Inggris · PLOS Scopus

Background: Severe asthma is associated with T helper (TH) 2 and 17 cell activation, airway neutrophilia and phosphoinositide-3-kinase (PI3K) activation. Asthma exacerbations are commonly caused by rhinovirus (RV) and also associated with PI3K-driven inflammation. Anthraquinone derivatives have…