57 hasil untuk "Ajay kumar"

Role of Staphylococcus aureus Virulence Factors in Inducing Inflammation and Vascular Permeability in a Mouse Model of Bacterial Endophthalmitis

Ajay Kumar; Ashok Kumar

PLOS ONE, Vol. 10 No. 6 · 2015 · Inggris · PLOS Scopus

Staphylococcus (S.) aureus is a common causative agent of bacterial endophthalmitis, a vision threatening complication of eye surgeries. The relative contribution of S. aureus virulence factors in the pathogenesis of endophthalmitis remains unclear. Here, we comprehensively analyzed the development…

Towards a new perspective: Exploring the variability of conditional risk factors for multimorbidity susceptibility among older adults in India

Ajay Kumar; Suryakant Yadav

PLOS One, Vol. 20 No. 6 · 2025 · Inggris · PLOS Scopus

Background: There is a lack of substantive evidence on the epidemiology of multimorbidity in low and middle-income countries (LMICs). India is also undergoing through the major demographic shift marked by the rapidly aging population and followed by significantly elevated implications to…

Modeling the spectrum and determinants of multimorbidity risk among older adults in India

Ajay Kumar; Bharti Singh

PLOS One, Vol. 20 No. 5 · 2025 · Inggris · PLOS Scopus

Background: India is passing through a parallel phase of demographic and epidemiological transition coupled with the shifting burden of multimorbidity. Unhealthy ageing and escalating morbidity burden have been identified as key drivers of this shifting multimorbidity risk among older adults in…

Phospholipid Mediated Activation of Calcium Dependent Protein Kinase 1 ( Ca CDPK1) from Chickpea: A New Paradigm of Regulation

Ajay Kumar Dixit; Chelliah Jayabaskaran

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Phospholipids, the major structural components of membranes, can also have functions in regulating signaling pathways in plants under biotic and abiotic stress. The effects of adding phospholipids on the activity of stress-induced calcium dependent protein kinase (CaCDPK1) from chickpea are…

Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation

Shiva Kant; Ajay Kumar; Sukh Mahendra Singh

PLoS ONE, Vol. 8 No. 12 · 2013 · Inggris · PLOS Scopus

Orlistat, an inhibitor of fatty acid synthase (FASN), acts as an antitumor agent by blocking de novo fatty acid synthesis of tumor cells. Although, myelopoiesis also depends on de novo fatty acid synthesis, the effect of orlistat on differentiation of macrophages, which play a central role in…

Stem cell factor and NSC87877 combine to enhance c-Kit mediated proliferation of human megakaryoblastic cells

Pawan Kumar Raghav; Ajay Kumar Singh; Gurudutta Gangenahalli

PLOS ONE, Vol. 13 No. 11 · 2018 · Inggris · PLOS Scopus

Enhancement of hematopoietic stem cells (HSCs) proliferation is a central aim in bone marrow transplantation (BMT). A stem cell factor (SCF) and c-Kit mediated extracellular signaling trigger proliferation of HSCs. This signaling is negatively regulated by protein tyrosine phosphatases (PTPs)…

Correction: Stem cell factor and NSC87877 combine to enhance c-Kit mediated proliferation of human megakaryoblastic cells

Pawan Kumar Raghav; Ajay Kumar Singh; Gurudutta Gangenahalli

PLOS ONE, Vol. 13 No. 12 · 2018 · Inggris · PLOS Scopus

Recognizing Disguised Faces: Human and Machine Evaluation

Tejas Indulal Dhamecha; Richa Singh; Mayank Vatsa dkk.

PLoS ONE, Vol. 9 No. 7 · 2014 · Inggris · PLOS Scopus

Face verification, though an easy task for humans, is a long-standing open research area. This is largely due to the challenging covariates, such as disguise and aging, which make it very hard to accurately verify the identity of a person. This paper investigates human and machine performance for…

Characterization of Aloe Barbadensis Miller leaves as a potential electrical energy source with optimum experimental setup conditions

Peng Lean Chong; Ajay Kumar Singh; Swee Leong Kok

PLOS ONE, Vol. 14 No. 6 · 2019 · Inggris · PLOS Scopus

Electrical energy can be harvested from the living plants as a new potential renewable energy source. Characterization of the electrical signal is needed to enable an optimum energy harvesting setup condition. In the present paper, an investigation is conducted to analyze the characteristic of Aloe…

Potential application of Aloe Vera-derived plant-based cell in powering wireless device for remote sensor activation

Peng Lean Chong; Ajay Kumar Singh; Swee Leong Kok

PLOS ONE, Vol. 14 No. 12 · 2019 · Inggris · PLOS Scopus

It is well proven that electrical energy can be harvested from the living plants which can be used as a potential renewable energy source for powering wireless devices in remote areas where replacing or recharging the battery is a difficult task. Therefore, harvesting electrical energy from living…

Magnetic Resonance Imaging Is Sensitive to Pathological Amelioration in a Model for Laminin-Deficient Congenital Muscular Dystrophy (MDC1A)

Ravneet Vohra; Anthony Accorsi; Ajay Kumar dkk.

PLOS ONE, Vol. 10 No. 9 · 2015 · Inggris · PLOS Scopus

Purpose: To elucidate the reliability of MRI as a non-invasive tool for assessing in vivo muscle health and pathological amelioration in response to Losartan (Angiotensin II Type 1 receptor blocker) in DyW mice (mouse model for Laminin-deficient Congenital Muscular Dystrophy Type 1A). Methods…

Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer

Ajay Kumar; Catherine Corey; Iain Scott dkk.

PLOS ONE, Vol. 11 No. 8 · 2016 · Inggris · PLOS Scopus

Minnelide/Triptolide (TL) has recently emerged as a potent anticancer drug in non-small cell lung cancer (NSCLC). However, the precise mechanism of its action remains ambiguous. In this study, we elucidated the molecular basis for TL-induced cell death in context to p53 status. Cell death was…

Conserved Surface Accessible Nucleoside ABC Transporter Component SP0845 Is Essential for Pneumococcal Virulence and Confers Protection In Vivo

Sneha Saxena; Naeem Khan; Ruchika Dehinwal dkk.

PLOS ONE, Vol. 10 No. 2 · 2015 · Inggris · PLOS Scopus

Streptococcus pneumoniae is a leading cause of bacterial pneumonia, sepsis and meningitis. Surface accessible proteins of S. pneumoniae are being explored for the development of a protein-based vaccine in order to overcome the limitations of existing polysaccharide-based pneumococcal vaccines. To…

Immunization of Mastomys coucha with Brugia malayi Recombinant Trehalose-6-Phosphate Phosphatase Results in Significant Protection against Homologous Challenge Infection

Susheela Kushwaha; Prashant Kumar Singh; Ajay Kumar Rana dkk.

PLoS ONE, Vol. 8 No. 8 · 2013 · Inggris · PLOS Scopus

Development of a vaccine to prevent or reduce parasite development in lymphatic filariasis would be a complementary approach to existing chemotherapeutic tools. Trehalose-6-phosphate phosphatase of Brugia malayi (Bm-TPP) represents an attractive vaccine target due to its absence in mammals…

PpTFDB: A pigeonpea transcription factor database for exploring functional genomics in legumes

Akshay Singh; Ajay Kumar Sharma; Nagendra Kumar Singh dkk.

PLOS ONE, Vol. 12 No. 6 · 2017 · Inggris · PLOS Scopus

Pigeonpea (Cajanus cajan L.), a diploid legume crop, is a member of the tribe Phaseoleae. This tribe is descended from the millettioid (tropical) clade of the subfamily Papilionoideae, which includes many important legume crop species such as soybean (Glycine max), mung bean (Vigna radiata), cowpea…

HIF1α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5

Yi Ran No; Sei-Jung Lee; Ajay Kumar dkk.

PLOS ONE, Vol. 10 No. 9 · 2015 · Inggris · PLOS Scopus

Macrophage migration inhibitory factor (MIF) is a cytokine that has broad effects on immune system and inflammatory response. A growing body of evidence implicates the role of MIF in tumor growth and metastasis. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates colon cancer cell…

Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis

Himanshu Rai; Nakul Sinha; Sudeep Kumar dkk.

PLOS ONE, Vol. 11 No. 4 · 2016 · Inggris · PLOS Scopus

Several researchers have reported significant association of numerous single nucleotide polymorphisms (SNPs) residing in the interleukin-1 (IL-1) gene cluster with coronary artery disease (CAD). However, their association status amongst North Indian ancestry (NIA) have never been systematically…

Nature’s grip: Unveiling the architecture and proteomics of the adhesive organ of a hill stream catfish, Pterygoplichthys disjunctivus

Jitendra Kumar Sharma; Arunima; Usha Kumari dkk.

PLOS One, Vol. 20 No. 10 · 2025 · Inggris · PLOS Scopus

Light microscopy, scanning electron microscopy, and proteomics analysis using high-resolution accurate mass spectrometry exhibit significant adaptive structural modifications and characteristic proteins in the adhesive organ (AO) of Pterygoplichthys disjunctivus, that could assist the adhesion of…

Efficacy and Safety of Once-Daily Insulin Degludec/Insulin Aspart versus Insulin Glargine (U100) for 52 Weeks in Insulin-Naïve Patients with Type 2 Diabetes: A Randomized Controlled Trial

Ajay Kumar; Edward Franek; Jonathan Wise dkk.

PLOS ONE, Vol. 11 No. 10 · 2016 · Inggris · PLOS Scopus

Purpose: The efficacy and safety of insulin degludec/insulin aspart (IDegAsp) once daily (OD) compared with insulin glargine U100 (IGlar) OD over 52 weeks in insulin-naïve adults with type 2 diabetes mellitus (T2DM) was investigated. Methods: In this open-label, parallel-group treat-to-target…

Nucleolar Proteins Suppress Caenorhabditis elegans Innate Immunity by Inhibiting p53/CEP-1

Laura E. Fuhrman; Ajay Kumar Goel; Jason Smith dkk.

PLoS Genetics, Vol. 5 No. 9 · 2009 · Inggris · PLOS Scopus

The tumor suppressor p53 has been implicated in multiple functions that play key roles in health and disease, including ribosome biogenesis, control of aging, and cell cycle regulation. A genetic screen for negative regulators of innate immunity in Caenorhabditis elegans led to the identification…