28 hasil untuk "Alexander Teumer"

Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks

Ann-Kristin Becker; Till Ittermann; Markus Dörr dkk.

PLOS ONE, Vol. 17 No. 7 · 2022 · Inggris · PLOS Scopus

Background: Approaching epidemiological data with flexible machine learning algorithms is of great value for understanding disease-specific association patterns. However, it can be difficult to correctly extract and understand those patterns due to the lack of model interpretability. Method: We…

Correction: Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks

Ann-Kristin Becker; Till Ittermann; Markus Dörr dkk.

PLOS ONE, Vol. 18 No. 11 · 2023 · Inggris · PLOS Scopus

Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population

Pawel Gaj; Natalia Maryan; Ewa E. Hennig dkk.

PLoS ONE, Vol. 7 No. 4 · 2012 · Inggris · PLOS Scopus

Background: Prostate cancer (PCa) and colorectal cancer (CRC) are the most commonly diagnosed cancers and cancer-related causes of death in Poland. To date, numerous single nucleotide polymorphisms (SNPs) associated with susceptibility to both cancer types have been identified, but their effect on…

Mitochondrial DNA Variants in Obesity

Nadja Knoll; Ivonne Jarick; Anna-Lena Volckmar dkk.

PLoS ONE, Vol. 9 No. 5 · 2014 · Inggris · PLOS Scopus

Heritability estimates for body mass index (BMI) variation are high. For mothers and their offspring higher BMI correlations have been described than for fathers. Variation(s) in the exclusively maternally inherited mitochondrial DNA (mtDNA) might contribute to this parental effect. Thirty-two to…

Mapping the Genetic Architecture of Gene Regulation in Whole Blood

Katharina Schramm; Carola Marzi; Claudia Schurmann dkk.

PLoS ONE, Vol. 9 No. 4 · 2014 · Inggris · PLOS Scopus

Background: We aimed to assess whether whole blood expression quantitative trait loci (eQTLs) with effects in cis and trans are robust and can be used to identify regulatory pathways affecting disease susceptibility. Materials and Methods: We performed whole-genome eQTL analyses in 890 participants…

Analyzing Illumina Gene Expression Microarray Data from Different Tissues: Methodological Aspects of Data Analysis in the MetaXpress Consortium

Claudia Schurmann; Katharina Heim; Arne Schillert dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Microarray profiling of gene expression is widely applied in molecular biology and functional genomics. Experimental and technical variations make meta-analysis of different studies challenging. In a total of 3358 samples, all from German population-based cohorts, we investigated the effect of data…

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

Carsten A. Böger; Mathias Gorski; Man Li dkk.

PLoS Genetics, Vol. 7 No. 9 · 2011 · Inggris · PLOS Scopus

Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD…

Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

Gian Andri Thun; Medea Imboden; Ilaria Ferrarotti dkk.

PLoS Genetics, Vol. 9 No. 8 · 2013 · Inggris · PLOS Scopus

Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood. Since low AAT serum levels fail to protect pulmonary tissue from enzymatic degradation, these polymorphisms also increase the risk for early onset…

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

Guangju Zhai; Alexander Teumer; Lisette Stolk dkk.

PLoS Genetics, Vol. 7 No. 4 · 2011 · Inggris · PLOS Scopus

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands—yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the…

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

Melanie Kolz; Toby Johnson; Serena Sanna dkk.

PLoS Genetics, Vol. 5 No. 6 · 2009 · Inggris · PLOS Scopus

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent…

Genetic Determinants of Serum Testosterone Concentrations in Men

Claes Ohlsson; Henri Wallaschofski; Kathryn L. Lunetta dkk.

PLoS Genetics, Vol. 7 No. 10 · 2011 · Inggris · PLOS Scopus

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts…

Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

Vesna Boraska; Aaron Day-Williams; Christopher S. Franklin dkk.

PLoS ONE, Vol. 7 No. 3 · 2012 · Inggris · PLOS Scopus

Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the…

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

Sandosh Padmanabhan; Olle Melander; Toby Johnson dkk.

PLoS Genetics, Vol. 6 No. 10 · 2010 · Inggris · PLOS Scopus

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We…

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

Clive J. Hoggart; Giulia Venturini; Massimo Mangino dkk.

PLoS Genetics, Vol. 10 No. 7 · 2014 · Inggris · PLOS Scopus

The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous…

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

Wenbo Tang; Matthew Kowgier; Daan W. Loth dkk.

PLoS ONE, Vol. 9 No. 7 · 2014 · Inggris · PLOS Scopus

Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of change in forced expiratory volume in the first…

Multiple Loci Are Associated with White Blood Cell Phenotypes

Michael A. Nalls; David J. Couper; Toshiko Tanaka dkk.

PLoS Genetics, Vol. 7 No. 6 · 2011 · Inggris · PLOS Scopus

White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied…

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

Paul S. de Vries; Maria Sabater-Lleal; Daniel I. Chasman dkk.

PLOS ONE, Vol. 12 No. 1 · 2017 · Inggris · PLOS Scopus

An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In…

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Andrea D. Coviello; Robin Haring; Melissa Wellons dkk.

PLoS Genetics, Vol. 8 No. 7 · 2012 · Inggris · PLOS Scopus

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as…

Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

Conall M. O'Seaghdha; Hongsheng Wu; Qiong Yang dkk.

PLoS Genetics, Vol. 9 No. 9 · 2013 · Inggris · PLOS Scopus

Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based…

No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects

Jens Baumert; Jie Huang; Barbara McKnight dkk.

PLoS ONE, Vol. 9 No. 12 · 2014 · Inggris · PLOS Scopus

Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated…