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Artikel Jurnal Teks lengkap
Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate
Flaviviruses represent a significant global health threat and relatively few licensed vaccines exist to protect against them. Insect-specific flaviviruses (ISFVs) are incapable of replication in humans and have emerged as a novel and promising tool for flavivirus vaccine development. ISFV-based…
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Artikel Jurnal Teks lengkap
Peli1 signaling blockade attenuates congenital zika syndrome
Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in…