17 results for "Azza Said"
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Journal Article
Blood Eosinophil Levels in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Background and Objective: Peripheral blood eosinophils are emerging as an accessible biomarker in chronic obstructive pulmonary disease. This study aimed to evaluate the prevalence, clinical characteristics, and hospital outcomes of eosinophilic versus non-eosinophilic acute exacerbations of COPD…
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Rabbit hunter uveitis: case report of tularemia uveitis
BACKGROUND: Literature reports on ophthalmological manifestations related to tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud’s oculoglandular syndrome, which consists of the association of conjunctivitis with preauricular lymphadenitis. In this paper…
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Chest imaging's diagnostic and prognostic relevance in COVID-19; a review article
Early diagnosis of coronavirus disease of 2019 (COVID-19) can help restrict the disease by allowing infection control measures to be implemented quickly, limiting the disease's spread. Although nasopharyngeal swab nucleic acid testing is the gold standard for diagnosis, proper sampling and…
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Experimental Analysis of Mimivirus Translation Initiation Factor 4a Reveals Its Importance in Viral Protein Translation during Infection of Acanthamoeba polyphaga
The Acanthamoeba polyphaga mimivirus is the first giant virus ever described, with a 1.2-Mb genome which encodes 979 proteins, including central components of the translation apparatus. One of these proteins, R458, was predicted to initiate translation, although its specific role remains unknown…
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Risk factors analysis for mortality among a cohort of lung cancer patients
Background: Over the last few decades, the worldwide burden of cancer has been increased. More than half of the 18.1 million people diagnosed with cancer in 2018 died. Lung cancer diagnoses and deaths are on the rise. So that it is very important to investigate the factors that influence lung…
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Clinical Outcomes of Different Phenotypes of Chronic Obstructive Pulmonary Disease
Introduction: Chronic obstructive pulmonary disease (COPD) is a critically important international health problem. Aim of the study: The aim of this study was to: Assess the effect of different COPD phenotypes on disease outcomes as regard disease severity, inflammatory burden, comorbidity and…
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Sepsis-Related Mortality Among Patients with Pulmonary Disorders
Background: Background: Sepsis is a one cause of increased morbidity and mortality in intensive care units (ICUs). Most studies on sepsis are performed on patients admitted in general or surgical ICU, with limited evaluation on patients admitted at the Respiratory Intensive care unit (RICU) with…
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Draft genome of Gemmata massiliana sp. nov, a water-borne Planctomycetes species exhibiting two variants
Gemmata massiliana is a new Planctomycetes bacterium isolated from a hospital water network in France, using a new culture medium. It is an aerobic microorganism with optimal growth at pH 8, at 30 °C and salinity ≤ 1.25 % NaCl. G. massiliana is resistant to β-lactam antibiotics, due to lack of…
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Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp.
Arthropod-borne Rickettsia species are obligate intracellular bacteria which are pathogenic for humans. Within this genus, Rickettsia slovaca and Rickettsia conorii cause frequent and potentially severe infections, whereas Rickettsia raoultii and Rickettsia massiliae cause rare and milder…
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Cell Extract-Containing Medium for Culture of Intracellular Fastidious Bacteria
The culture of fastidious microorganisms is a critical step in infectious disease studies. As a proof-of-concept experiment, we evaluated an empirical medium containing eukaryotic cell extracts for its ability to support the growth of Coxiella burnetii. Here, we demonstrate the exponential growth…
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New Beta-lactamases in Candidate Phyla Radiation: Owning Pleiotropic Enzymes Is a Smart Paradigm for Microorganisms with a Reduced Genome
The increased exploitation of microbial sequencing methods has shed light on the high diversity of new microorganisms named Candidate Phyla Radiation (CPR). CPR are mainly detected via 16S rRNA/metabarcoding analyses or metagenomics and are found to be abundant in all environments and present in…
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A protein of the metallo-hydrolase/oxidoreductase superfamily with both beta-lactamase and ribonuclease activity is linked with translation in giant viruses
Proteins with a metallo-beta-lactamase (MBL) fold have been largely studied in bacteria in the framework of resistance to beta-lactams, but their spectrum of activities is broader. We show here that the giant Tupanvirus also encodes a MBL fold-protein that has orthologs in other giant viruses, a…
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Complexin in ivermectin resistance in body lice
Ivermectin has emerged as very promising pediculicide, particularly in cases of resistance to commonly used pediculicides. Recently, however, the first field-evolved ivermectin-resistance in lice was reported. To gain insight into the mechanisms underlying ivermectin-resistance, we both looked for…
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Yersinia pestis halotolerance illuminates plague reservoirs
The plague agent Yersinia pestis persists for years in the soil. Two millennia after swiping over Europe and North Africa, plague established permanent foci in North Africa but not in neighboring Europe. Mapping human plague foci reported in North Africa for 70 years indicated a significant…
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Proteomics and Lipidomics Investigations to Decipher the Behavior of Willaertia magna C2c Maky According to Different Culture Modes
Willaertia magna C2c Maky is a free-living amoeba that has demonstrated its ability to inhibit the intracellular multiplication of some Legionella pneumophila strains, which are pathogenic bacteria inhabiting the aquatic environment. The Amoeba, an industry involved in the treatment of…
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Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea
β-lactam antibiotics have a well-known activity which disturbs the bacterial cell wall biosynthesis and may be cleaved by β-lactamases. However, these drugs are not active on archaea microorganisms, which are naturally resistant because of the lack of β-lactam target in their cell wall. Here, we…
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Related Giant Viruses in Distant Locations and Different Habitats: Acanthamoeba polyphaga moumouvirus Represents a Third Lineage of the Mimiviridae That Is Close to the Megavirus Lineage
The 1,021,348 base pair genome sequence of the Acanthamoeba polyphaga moumouvirus, a new member of the Mimiviridae family infecting Acanthamoeba polyphaga, is reported. The moumouvirus represents a third lineage beside mimivirus and megavirus. Thereby, it is a new member of the recently proposed…