23 results for "Bellucci, Devis"
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Low-Temperature Sintering of a New Bioactive Glass Enriched with Magnesium Oxide and Strontium Oxide
The recent research on bioactive glasses (BGs) has mainly moved on two fronts: (1) introducing ions of therapeutic interest in their composition and (2) the development of scaffolds, fibers, coatings and sintered products starting from BGs in powder form. In this case, the main obstacle to overcome…
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A New Highly Bioactive Composite for Scaffold Applications: A Feasibility Study
Hydroxyapatite (HA) has been widely investigated as scaffolding material for bone tissue engineering, mainly for its excellent biocompatibility. Presently, there is an increasing interest in the composites of hydroxyapatite with bioactive glasses, with the aim to obtain systems with improved…
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An Enhanced Bioactive Glass Composition with Improved Thermal Stability and Sinterability
The development of new bioactive glasses (BGs) with enhanced bioactivity and improved resistance to crystallization is crucial for overcoming the main challenges faced by commercial BGs. Most shaping processes require thermal treatments, which can induce partial crystallization, negatively…
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A Review of Bioactive Glass/Natural Polymer Composites: State of the Art
Collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose are biocompatible and non-cytotoxic, being attractive natural polymers for medical devices for both soft and hard tissues. However, such natural polymers have low bioactivity and poor mechanical properties, which…
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Additive Manufacturing of Polymer/Bioactive Glass Scaffolds for Regenerative Medicine: A Review
Tissue engineering (TE) is a branch of regenerative medicine with enormous potential to regenerate damaged tissues using synthetic grafts such as scaffolds. Polymers and bioactive glasses (BGs) are popular materials for scaffold production because of their tunable properties and ability to interact…
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The Role of Artificial Intelligence in Biomaterials Science: A Review
Biomaterials can be defined as materials that interact positively with living tissues, restoring compromised functions, or enhancing tissue regeneration. Currently, biomaterial research often relies on a “trial-and-error method”, involving numerous experiments driven largely by experience. This…
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Effect of Thermal Treatments and Ion Substitution on Sintering and Crystallization of Bioactive Glasses: A Review
Bioactive glasses (BGs) are promising materials for bone regeneration due to their ability to bond with living bone tissue. However, thermal stability and mechanical properties of BGs need improvement for better clinical performance. In this paper, we present an overview of the influence of…
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The Assessment of Bioactivity and Biological Responsiveness in Bioactive Glasses and Ceramics: A Review of Available Techniques
The development of bioactive glasses (BGs) and ceramics, such as β-Tricalcium phosphate (β-TCP), Hydroxyapatite (HAp), and apatite-wollastonite (A-W), has revolutionized regenerative medicine (RM), offering innovative solutions for bone and tissue repair, due to the ability of these materials to…
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On the in Vitro Biocompatibility Testing of Bioactive Glasses
In this work, a new 3D cellular model—based on human bone marrow mesenchymal stem cells (BM–MSCs)—was used for the first time to test the 45S5 Bioglass(®) (45S5). Such a model, previously used to evaluate the biologic performance of two novel bioactive glasses, suggested out the regenerative…
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Chitosan-Based Bioactive Glass Gauze: Microstructural Properties, In Vitro Bioactivity, and Biological Tests
Passive commercial gauzes were turned into interactive wound dressings by impregnating them with a chitosan suspension. To further improve healing, and cell adhesion and proliferation, chitosan/bioactive glass wound dressings were produced with the addition of (i) 45S5, (ii) a Sr- and Mg-containing…
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A Novel Bioactive Glass Containing Therapeutic Ions with Enhanced Biocompatibility
A novel bioactive glass containing therapeutic ions with enhanced biocompatibility was designed and produced by the classical melt-quenching route. Starting from a very promising composition (Bio_MS), which combined bioactivity and high crystallization temperature, the ratio between some oxides was…
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Bioactive Glasses in Periodontal Regeneration: Existing Strategies and Future Prospects—A Literature Review
The present review deals with bioactive glasses (BGs), a class of biomaterials renowned for their osteoinductive and osteoconductive capabilities, and thus widely used in tissue engineering, i.e., for the repair and replacement of damaged or missing bone. In particular, the paper deals with…
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Advanced Open-Celled Structures from Low-Temperature Sintering of a Crystallization-Resistant Bioactive Glass
Most materials for bone tissue engineering are in form of highly porous open-celled components (porosity >70%) developed by means of an adequate coupling of formulations and manufacturing technologies. This paper is dedicated to porous components from BGMS10 bioactive glass, originally designed to…
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Adhesive Bioinspired Coating for Enhancing Glass-Ceramics Scaffolds Bioactivity
Bioceramic scaffolds, composed of a biphasic composite containing bioactive glass and hydroxyapatite, were prepared in this work to overcome the intrinsic limits of the two components taken separately (in particular, their specific reactivities and dissolution rates, which should be tunable as a…
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A New Bioactive Glass/Collagen Hybrid Composite for Applications in Dentistry
Bioactive glasses (BGs) are currently employed in a wide range of medical and dentistry applications by virtue of their bone-bonding ability. The incorporation of BGs into a collagen matrix may be used to combine the regenerative potential of these materials with the specific biological advantages…
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Bioactive Glass Applications: A Literature Review of Human Clinical Trials
The use of bioactive glasses in dentistry, reconstructive surgery, and in the treatment of infections can be considered broadly beneficial based on the emerging literature about the potential bioactivity and biocompatibility of these materials, particularly with reference to Bioglass(®) 45S5…
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Bone Regeneration by Novel Bioactive Glasses Containing Strontium and/or Magnesium: A Preliminary In-Vivo Study
In this work, a set of novel bioactive glasses have been tested in vivo in an animal model. The new compositions, characterized by an exceptional thermal stability and high in vitro bioactivity, contain strontium and/or magnesium, whose biological benefits are well documented in the literature. To…
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Alginate-Sr/Mg Containing Bioactive Glass Scaffolds: The Characterization of a New 3D Composite for Bone Tissue Engineering
In bone regeneration, combining natural polymer-based scaffolds with Bioactive Glasses (BGs) is an attractive strategy to improve the mechanical properties of the structure, as well as its bioactivity and regenerative potential. Methods: For this purpose, a well-studied alginate/hydroxyapatite…
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Inclusion of Magnesium- and Strontium-Enriched Bioactive Glass into Electrospun PCL Scaffolds for Tissue Regeneration
Bioactive glass (BG) is a promising material known for its osteogenic, osteoinductive, antimicrobial, and angiogenic properties. For this reason, melt-quench-derived BG powders embedded into composite electrospun poly(ε-caprolactone) (PCL) mats represent an interesting option for the fabrication of…
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Human Mesenchymal Stem Cell Combined with a New Strontium-Enriched Bioactive Glass: An ex-vivo Model for Bone Regeneration
A 3D cellular model that mimics the potential clinical application of a biomaterial is here applied for the first time to a bioactive glass, in order to assess its biological potential. A recently developed bioactive glass (BGMS10), whose composition contained strontium and magnesium, was produced…