34 hasil untuk "Benfaremo, Devis"
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Artikel Jurnal Teks lengkap
Is There a Future for Anti-CD38 Antibody Therapy in Systemic Autoimmune Diseases?
CD38 is a type II glycoprotein highly expressed on plasmablasts, short-lived and long-lived plasma cells, but weakly expressed on other lymphoid cells, myeloid cells and non-hematopoietic cells. This expression pattern makes CD38 an interesting target for a targeted therapy aiming to deplete…
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Skin ultrasound in systemic sclerosis: past, present and exciting future
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Artikel Jurnal Teks lengkap
Diagnosis and management of leukocytoclastic vasculitis
Leukocytoclastic vasculitis (LCV) is a histopathologic description of a common form of small vessel vasculitis (SVV), that can be found in various types of vasculitis affecting the skin and internal organs. The leading clinical presentation of LCV is palpable purpura and the diagnosis relies on…
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Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs
Inflammatory bowel disease-associated spondyloarthritis is a systemic disease characterized by the chronic inflammation of both the gastrointestinal tract and the musculoskeletal system. Since inflammatory bowel disease-associated spondyloarthritis has been associated with a significant diagnostic…
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Mycophenolate mofetil-induced colitis in a patient with systemic sclerosis
We present the case of a 44-year-old woman affected by systemic sclerosis (SSc) who was admitted to our department for abdominal pain, nausea, vomiting and fever. Imaging studies showed the presence of a thickened colon wall involving the descending colon and the sigma, while a subsequent endoscopy…
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Atypical neutrophilic panniculitis as presentation of BCR-ABL1-negative chronic myeloid leukaemia
We report the case of an otherwise healthy 60-year-old man presenting with fever, leucocytosis and a painful swelling of the right calf. We initially performed cultural and cytological examination of the popliteal fossa mass, but the results were disappointingly inconclusive. The subsequent…
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Atypical Spontaneous Hematomas in a Patient with Severe Coronavirus Disease 2019 (COVID-19)
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Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature
BACKGROUND: Immune checkpoint inhibitors are a new promising class of antitumor drugs that have been associated with a number of immune-related Adverse Events (AEs), including musculoskeletal and rheumatic disease. METHODS: We searched Medline reviewing reports of musculoskeletal and rheumatic AEs…
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Aseptic inflammation of prosthetic knee in a patient affected by rheumatoid arthritis
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Artikel Jurnal Teks lengkap
Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches
Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by small vessel alterations and progressive fibrosis of the skin and internal organs. The combination of a predisposing genetic background and triggering factors that causes a persistent activation of immune…
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Isolated Aortitis Presenting with an Annoying Persistent Cough: A Case Report
OBJECTIVES: To report a case of idiopathic aortitis, presenting with chronic cough. MATERIALS AND METHODS: The Authors describe the case of a 72-year-old man with dry cough, worsening fatigue, weight loss and elevated systemic inflammatory markers. RESULTS: A PET-CT scan showed diffuse thickening…
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Putative functional pathogenic autoantibodies in systemic sclerosis
Systemic sclerosis (scleroderma, SSc) is a systemic disease characterized by vascular lesions, fibrosis, and circulating autoantibodies. A complex interplay between innate and adaptive immunity, and with regard to the latter, between humoral and cellular immunity, is believed to be involved in SSc…
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PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis
Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue characterized by vascular alterations, immune/inflammatory manifestations, and organ fibrosis. SSc pathogenesis is complex and still poorly understood. Therefore, effective therapies are lacking and remain…
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Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a…
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Systemic Sclerosis: A Key Model of Endothelial Dysfunction
Systemic sclerosis (SSc) is a heterogeneous disease characterized by vascular alterations, immune dysregulation, and fibrosis. Solid evidence supports the hypothesis that endothelial dysfunction is the key player in SSc vascular injury and a critical factor concurring to the initiation of SSc…
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Role of cognitive impairment and malnutrition as determinants of quality of life in patients with systemic sclerosis
BACKGROUND: Increasing evidence supports the presence of cognitive impairment in patients with systemic sclerosis. Malnutrition is a well-known severe complication of systemic sclerosis and is a consequence of multiple factors, mainly oropharyngeal and gastrointestinal involvement. Recent studies…
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Screening and Analysis of Possible Drugs Binding to PDGFRα: A Molecular Modeling Study
The platelet-derived growth factor receptor (PDGFR) is a membrane tyrosine kinase receptor involved in several metabolic pathways, not only physiological but also pathological, as in tumor progression, immune-mediated diseases, and viral diseases. Considering this macromolecule as a druggable…
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Hypogammaglobulinemia in patients affected by limited cutaneous systemic sclerosis: Case series and review of the literature
BACKGROUND: Hypogammaglobulinemia is a condition that can be related to both primary and secondary immunodeficiencies. While the role of primary immunodeficiency in immune-mediated diseases is well known, its occurrence in systemic sclerosis is not reported. OBJECTIVES: This study aims to describe…
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Artikel Jurnal Teks lengkap
New Insights in Physical Therapy and Rehabilitation in Psoriatic Arthritis: A Review
Psoriatic arthritis (PsA) is a complex, multiform and chronic inflammatory disease characterized by the association of psoriasis and arthritis with other musculoskeletal and extra-articular manifestations. The treatment of PsA is rapidly evolving due to the introduction of new biologic and…