1 hasil untuk "Brian Benjamin"

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Benjamin J. Solomon; Lavinia Tan; W. Marston Linehan dkk.

Journal of Thoracic Oncology · 2020 · Inggris · OpenAlex Scopus

INTRODUCTION: Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unprecedented efficacy in tumors positive for RET fusions or mutations, notably RET fusion-positive NSCLC and RET-mutated medullary thyroid cancer (MTC)…