6 hasil untuk "Burhan A. Khan"

Prenatal alcohol exposure among Alaska Native/American Indian infants

Burhan A. Khan; Renee F. Robinson; Julia J. Smith dkk.

International Journal of Circumpolar Health, Vol. 72 No. 0 · 2013 · Inggris · DOAJ Scopus

Background. Recent reports indicate a decline in rates of Fetal Alcohol Syndrome (FAS) among Alaska Native and American Indian (AN/AI) infants. Nevertheless, AN/AI infants remain disproportionately impacted by the effects of prenatal alcohol exposure. Methods. AN/AI pregnant women in their 3rd…

Mobile Genetic Element-Encoded Cytolysin Connects Virulence to Methicillin Resistance in MRSA

Shu Y. Queck; Burhan A. Khan; Rong Wang dkk.

PLoS Pathogens, Vol. 5 No. 7 · 2009 · Inggris · PLOS Scopus

Bacterial virulence and antibiotic resistance have a significant influence on disease severity and treatment options during bacterial infections. Frequently, the underlying genetic determinants are encoded on mobile genetic elements (MGEs). In the leading human pathogen Staphylococcus aureus, MGEs…

Juga tersedia di: DOAJ

Trends and factors associated with use of digital health technology among adults with serious psychological distress in the United States: A secondary data analysis of the National Health Interview Survey

Henry K. Onyeaka; Isaac Acquah; Joesph Firth dkk.

Population Medicine, Vol. 4 No. February · 2022 · Inggris · DOAJ Scopus

Introduction This study sought to investigate the trend and factors associated with DHT (Digital Health Tools) utilization among individuals with SPD (serious psychological distress) in the US. Methods Data were drawn from the 2013 to 2017 National Health Interview Survey. Descriptive statistics…

VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People

Lindsay M. Henderson; Renee F. Robinson; Lily Ray dkk.

Clinical and Translational Science, Vol. 12 No. 3 · 2019 · Inggris · DOAJ Scopus

Alaska Native and American Indian (AN/AI) people have unique pharmacogene variation that may affect warfarin disposition and therapeutic response. We performed targeted genotyping for cytochrome P450 (CYP)2C9, vitamin K epoxide oxidase reductase complex subunit 1 (VKORC1), CYP4F2, CYP4F11, and…

Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

Alison E. Fohner; Rachel Dalton; Kasse Skagen dkk.

Clinical and Translational Science, Vol. 14 No. 4 · 2021 · Inggris · DOAJ Scopus

Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet…