6 hasil untuk "Burridge, Kevin M."
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Artikel Jurnal Teks lengkap
Two-distinct polymer ubiquitin conjugates by photochemical grafting-from
Protein-polymer bioconjugates present a way to make enzymes more efficient and robust for industrial and medicinal applications. While much work has focused on mono-functional conjugates, i.e. conjugates with one type of polymer attached such as poly(ethylene glycol) or poly(N-isopropylacrylamide)…
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Characterizing the structure of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using RAFT polymerization for membrane protein spectroscopic studies
Membrane proteins play an important role in maintaining the structure and physiology of an organism. Despite their significance, spectroscopic studies involving membrane proteins remain challenging due to the difficulties in mimicking their native lipid bilayer environment. Membrane mimetic systems…
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The Effect of Lipid Saturation on the Formation of Styrene Maleic Acid Lipid Nanoparticles
The ability to use styrene maleic acid (SMA) to solubilize membrane proteins has been of significant interest. The formation of the lipid nanodiscs and extraction of the proteins without the use of detergent allows for the study of these membrane proteins in a more native environment. Traditional…
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Structural characterization of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using EPR spectroscopy
Spectroscopic studies of membrane proteins (MPs) are challenging due to difficulties in preparing homogenous and functional lipid membrane mimetic systems into which membrane proteins can properly fold and function. It has recently been shown that styrene-maleic acid (SMA) copolymers act as a…
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Artikel Jurnal Teks lengkap
Simple Derivatization of RAFT-Synthesized Styrene–Maleic Anhydride Copolymers for Lipid Disk Formulations
Styrene–maleic acid copolymers have received significant attention because of their ability to interact with lipid bilayers and form styrene–maleic acid copolymer lipid nanoparticles (SMALPs). However, these SMALPs are limited in their chemical diversity, with only phenyl and carboxylic acid…
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Artikel Jurnal Teks lengkap
Mapping protein–polymer conformations in bioconjugates with atomic precision
Rational design of protein–polymer bioconjugates is hindered by limited experimental data and mechanistic understanding on interactions between the two. In this communication, nuclear magnetic resonance (NMR) paramagnetic relaxation enhancement (PRE) reports on distances between paramagnetic spin…