96 hasil untuk "Chen Lin"

The strength of Nesterov’s accelerated gradient in boosting transferability of stealthy adversarial attacks

Chen Lin; Sheng Long

PLOS One, Vol. 20 No. 11 · 2025 · Inggris · PLOS Scopus

Deep neural networks have been shown to be highly vulnerable to adversarial examples—inputs crafted to mislead models by adding subtle, human-imperceptible perturbations. Transferability and stealthiness are two crucial metrics for evaluating adversarial attacks. However, these goals often…

Kermit Interacts with Gαo, Vang, and Motor Proteins in Drosophila Planar Cell Polarity

Chen Lin; Vladimir L. Katanaev

PLoS ONE, Vol. 8 No. 10 · 2013 · Inggris · PLOS Scopus

In addition to the ubiquitous apical-basal polarity, epithelial cells are often polarized within the plane of the tissue – the phenomenon known as planar cell polarity (PCP). In Drosophila, manifestations of PCP are visible in the eye, wing, and cuticle. Several components of the PCP signaling have…

Poly(Ethylene Glycol) as a Scaffold for High-Affinity Open-Channel Blockers of the Mouse Nicotinic Acetylcholine Receptor

Wan-Chen Lin; Stuart Licht

PLoS ONE, Vol. 9 No. 11 · 2014 · Inggris · PLOS Scopus

High-affinity blockers for an ion channel often have complex molecular structures that are synthetically challenging and/or laborious. Here we show that high-affinity blockers for the mouse nicotinic acetylcholine receptor (AChR) can be prepared from a structurally simple material, poly(ethylene…

Quercetin-4′- O -β-D-glucopyranoside (QODG) Inhibits Angiogenesis by Suppressing VEGFR2-Mediated Signaling in Zebrafish and Endothelial Cells

Chen Lin; Menghua Wu; Jianyong Dong

PLoS ONE, Vol. 7 No. 2 · 2012 · Inggris · PLOS Scopus

Background: Angiogenesis plays an important role in many physiological and pathological processes. Identification of small molecules that block angiogenesis and are safe and affordable has been a challenge in drug development. Hypericum attenuatum Choisy is a Chinese herb medicine commonly used for…

Characterization of the Role of Tumor Necrosis Factor Apoptosis Inducing Ligand (TRAIL) in Spermatogenesis through the Evaluation of Trail Gene-Deficient Mice

Yi-Chen Lin; John H. Richburg

PLoS ONE, Vol. 9 No. 4 · 2014 · Inggris · PLOS Scopus

TRAIL (TNFSF10/Apo2L) is a member of the tumor necrosis factor (TNF) superfamily of proteins and is expressed in human and rodent testis. Although the functional role of TRAIL in spermatogenesis is not known, TRAIL is recognized to induce apoptosis via binding to its cognate receptors; DR4…

CRBPDL: Identification of circRNA-RBP interaction sites using an ensemble neural network approach

Mengting Niu; Quan Zou; Chen Lin

PLOS Computational Biology, Vol. 18 No. 1 · 2022 · Inggris · PLOS Scopus

Circular RNAs (circRNAs) are non-coding RNAs with a special circular structure produced formed by the reverse splicing mechanism. Increasing evidence shows that circular RNAs can directly bind to RNA-binding proteins (RBP) and play an important role in a variety of biological activities. The…

An overview of GabRat edge disruption and its new extensions for unbiased quantification of disruptive camouflaging patterns using randomization technique

Masahiko Tanahashi; Min-Chen Lin; Chung-Ping Lin

PLOS One, Vol. 20 No. 7 · 2025 · Inggris · PLOS Scopus

Disruptive colorations are camouflaging patterns that use contrasting colorations to interrupt the continuity of object’s edge and disturb the observer’s visual recognition. The GabRat method has been introduced and widely used to quantify the strength of edge disruption. The original GabRat method…

Zinc Finger 280B Regulates sGCα1 and p53 in Prostate Cancer Cells

Shuai Gao; Chen-Lin Hsieh; Jun Zhou dkk.

PLoS ONE, Vol. 8 No. 11 · 2013 · Inggris · PLOS Scopus

The Zinc Finger (ZNF) 280B protein was identified as an unexpected target of an shRNA designed for sGCα1. Further analysis showed that these two proteins are connected in another way, with 280B up-regulation of sGCα1 expression. Knock-down and over-expression experiments showed that 280B serves…

Plastidial α-glucan phosphorylase 1 complexes with disproportionating enzyme 1 in Ipomoea batatas storage roots for elevating malto-oligosaccharide metabolism

Yi-Chen Lin; Shih-Chung Chang; Rong-Huay Juang

PLOS ONE, Vol. 12 No. 5 · 2017 · Inggris · PLOS Scopus

It has been proposed that malto-oligosaccharides (MOSs) are possibly recycled back into amylopectin biosynthesis via the sequential reactions catalyzed by plastidial α-glucan phosphorylase 1 (Pho1) and disproportionating enzyme 1 (Dpe1). In the present study, the reciprocal co-immunoprecipitation…

The Prognostic Value of Non-Linear Analysis of Heart Rate Variability in Patients with Congestive Heart Failure—A Pilot Study of Multiscale Entropy

Yi-Lwun Ho; Chen Lin; Yen-Hung Lin dkk.

PLoS ONE, Vol. 6 No. 4 · 2011 · Inggris · PLOS Scopus

Aims: The influences of nonstationarity and nonlinearity on heart rate time series can be mathematically qualified or quantified by multiscale entropy (MSE). The aim of this study is to investigate the prognostic value of parameters derived from MSE in the patients with systolic heart failure…

A Peptide against Soluble Guanylyl Cyclase α1: A New Approach to Treating Prostate Cancer

Shuai Gao; Chen-Lin Hsieh; Meenakshi Bhansali dkk.

PLoS ONE, Vol. 8 No. 5 · 2013 · Inggris · PLOS Scopus

Among the many identified androgen-regulated genes, sGCα1 (soluble guanylyl cyclase α1) appears to play a pivotal role in mediating the pro-cancer effects of androgens and androgen receptor. The classical role for sGCα1 is to heterodimerize with the sGCβ1 subunit, forming sGC, the enzyme that…

Peptide B targets soluble guanylyl cyclase α1 and kills prostate cancer cells

Jun Zhou; Shuai Gao; Chen-Lin Hsieh dkk.

PLOS ONE, Vol. 12 No. 8 · 2017 · Inggris · PLOS Scopus

Among androgen-regulated genes, soluble guanylyl cyclase α1 (sGCα1) is significant in promoting the survival and growth of prostate cancer cells and does so independent of nitric oxide (NO) signaling. Peptides were designed targeting sGCα1 to block its pro-cancer functions and one peptide is…

The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis

Shu Chen Lin; Zhi Hua Gan; Yang Yao dkk.

PLOS ONE, Vol. 10 No. 8 · 2015 · Inggris · PLOS Scopus

Background: Recent studies have shown that the forkhead box P3 (FOXP3) protein has a prognostic role in breast cancer. However, these results are controversial. Therefore, the aim of this meta-analysis was to clarify the prognostic role of FOXP3 expression in operable breast cancer cases. Methods…

Epidemiological Characteristics of Lower Extremity Cellulitis after a Typhoon Flood

Pei-Chen Lin; Hung-Jung Lin; How-Ran Guo dkk.

PLoS ONE, Vol. 8 No. 6 · 2013 · Inggris · PLOS Scopus

Objective: The flood after a typhoon may lead to increase in patients with cellulitis of lower limbs. However, the microbiological features of these cases are rarely reported. We conducted a study of patients with lower extremity cellulitis after a typhoon followed in southern Taiwan to study the…

A Highly Redundant Gene Network Controls Assembly of the Outer Spore Wall in S. cerevisiae

Coney Pei-Chen Lin; Carey Kim; Steven O. Smith dkk.

PLoS Genetics, Vol. 9 No. 8 · 2013 · Inggris · PLOS Scopus

The spore wall of Saccharomyces cerevisiae is a multilaminar extracellular structure that is formed de novo in the course of sporulation. The outer layers of the spore wall provide spores with resistance to a wide variety of environmental stresses. The major components of the outer spore wall are…

Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Drosophila Male Germline

Simon W. A. Titen; Ho-Chen Lin; Jayaram Bhandari dkk.

PLoS Genetics, Vol. 10 No. 2 · 2014 · Inggris · PLOS Scopus

When a dicentric chromosome breaks in mitosis, the broken ends cannot be repaired by normal mechanisms that join two broken ends since each end is in a separate daughter cell. However, in the male germline of Drosophila melanogaster, a broken end may be healed by de novo telomere addition. We find…

Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis

Ma Yubo; Li Yanyan; Li Li dkk.

PLOS ONE, Vol. 12 No. 4 · 2017 · Inggris · PLOS Scopus

Purpose: The aim of this study was to evaluate the therapeutic efficacy and safety of mesenchymal stem cells (MSCs) for the treatment of patients with knee osteoarthritis (OA). Materials: We performed a meta-analysis of relevant published clinical studies. An electronic search was conducted for…

The Pathogenesis of Human Cervical Epithelium Cells Induced by Interacting with Trichomonas vaginalis

Wei-Chen Lin; Wei-Ting Chang; Tsuey-Yu Chang dkk.

PLOS ONE, Vol. 10 No. 4 · 2015 · Inggris · PLOS Scopus

Background: Trichomonas vaginalis is a protozoan parasite that occurs in the urogenital-vaginal tract and is the primary causative agent of trichomoniasis, a common sexually transmitted disease in humans. The aggregation of this protozoan tends to destroy epithelial cells and induce pathogenesis…

Correction: Epidemiological Characteristics of Lower Extremity Cellulitis after a Typhoon Flood

Pei-Chen Lin; Hung-Jung Lin; How-Ran Guo dkk.

PLOS ONE, Vol. 12 No. 1 · 2017 · Inggris · PLOS Scopus

Risk of peripheral artery occlusive disease in patients with lower leg fracture who received fixation and non-fixation treatments: A population cohort study

Pin-Keng Shih; Jian-Xun Chen; Mei-Chen Lin dkk.

PLOS ONE, Vol. 17 No. 8 · 2022 · Inggris · PLOS Scopus

Background: The risk of peripheral artery occlusive disease (PAOD) in patients with lower leg fracture who underwent fixation procedures is not yet completely understood. Therefore, the current study aimed to examine the risk of subsequent PAOD in patients with lower leg fracture who received…