7 hasil untuk "Cheng, Pi-Cheng"
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Glutamate-Evoked Ca(2+) Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na(+)/K(+)-ATPase and Na(+)/Ca(2+)-Exchanger
Glutamate mediates photic entrainment of the central clock in the suprachiasmatic nucleus (SCN) by evoking intracellular Ca(2+) signaling mechanisms. However, the detailed mechanisms of glutamate-evoked Ca(2+) signals are not entirely clear. Here, we used a ratiometric Ca(2+) and Na(+) imaging…
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Artikel Jurnal Teks lengkap
Role of Intracellular Na(+) in the Regulation of [Ca(2+)](i) in the Rat Suprachiasmatic Nucleus Neurons
Transmembrane Ca(2+) influx is essential to the proper functioning of the central clock in the suprachiasmatic nucleus (SCN). In the rat SCN neurons, the clearance of somatic Ca(2+) following depolarization-induced Ca(2+) transients involves Ca(2+) extrusion via Na(+)/Ca(2+) exchanger (NCX) and…
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NCOG-22. ELDER AGE INSTEAD OF LOW EDUCATION PREDICTS POOR LANGUAGE FUNCTION IN RECURRENT LEFT HEMISPHERIC DIFFUSE GLIOMA PATIENTS
PURPOSE: Language processing is multifactorial, requiring interactions between cognitive functions and connections of cerebral cortexes and subcortical fibers in dominant hemisphere. Previously, we identified distinct patient factors and tumor characters influencing language performance in…
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Artikel Jurnal Teks lengkap
K(ATP) Channels Mediate Differential Metabolic Responses to Glucose Shortage of the Dorsomedial and Ventrolateral Oscillators in the Central Clock
The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP)-positive dorsomedial oscillator. While glucose…
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Artikel Jurnal Teks lengkap
The Na(+/)H(+)-Exchanger NHE1 Regulates Extra- and Intracellular pH and Nimodipine-sensitive [Ca(2+)](i) in the Suprachiasmatic Nucleus
The central clock in the suprachiasmatic nucleus (SCN) has higher metabolic activity than extra-SCN areas in the anterior hypothalamus. Here we investigated whether the Na(+)/H(+) exchanger (NHE) may regulate extracellular pH (pHe), intracellular pH (pHi) and [Ca(2+)](i) in the SCN. In hypothalamic…
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Artikel Jurnal Teks lengkap
Differential regulation of nimodipine-sensitive and -insensitive Ca(2+) influx by the Na(+)/Ca(2+) exchanger and mitochondria in the rat suprachiasmatic nucleus neurons
BACKGROUND: Transmembrane Ca(2+) influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na(+)/Ca(2+) exchanger (NCX) and mitochondria play a role in regulating…
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Artikel Jurnal Teks lengkap
ANGI-16. MECLOFENAMATE-INDUCED DYSREGULATION OF CALCIUM HOMEOSTASIS AND CYTOSKELETAL DYNAMICS CONTRIBUTES TO MALIGNANT GLIOMA INVASIVENESS
PURPOSE: Malignant gliomas exhibit highly invasive behavior, partly driven by dysregulated intracellular Ca(2+) signaling and cytoskeletal remodeling. Meclofenamate (MFA), a non-steroidal anti-inflammatory drug (NSAID) known to inhibit gap junctions and ion channels, has emerged as a candidate…