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2 results for "Chih-Lin Lin"

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Impact of Genetic Heterogeneity in Polymerase of Hepatitis B Virus on Dynamics of Viral Load and Hepatitis B Progression

Chi-Jung Huang; Chih-Feng Wu; Chia-Ying Lan et al.

PLoS ONE, Vol. 8 No. 7 · 2013 · English · PLOS Scopus

Objective: The hepatitis B virus (HBV)-polymerase region overlaps pre-S/S genes with high epitope density and plays an essential role in viral replication. We investigated whether genetic variation in the polymerase region determined long-term dynamics of viral load and the risk of hepatitis B…

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Circulating Programmed Death-1 as a Marker for Sustained High Hepatitis B Viral Load and Risk of Hepatocellular Carcinoma

Hsiang-Yun Cheng; Pei-Jen Kang; Ya-Hui Chuang et al.

PLoS ONE, Vol. 9 No. 11 · 2014 · English · PLOS Scopus

Objective: Recent evidence indicates a crucial role of the immunoinhibitory receptor programmed death-1 (PD-1) in enforcing T-cell dysfunction during chronic viral infection and cancer. We assessed the impact of circulating soluble PD-1 (sPD-1) levels on long-term dynamics of hepatitis B virus…

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