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Implications for methenamine hippurate use in recurrent urinary tract infection management: Formaldehyde resistance and altered urinary composition

Niamh C. Hodgkinson; Tabarak Al-Rubaye; Thomas C. P. Reed dkk.

PLOS Pathogens, Vol. 22 No. 3 · 2026 · Inggris · PLOS Scopus

Methenamine is a urinary antiseptic used to prevent urinary tract infections (UTI) via conversion to formaldehyde in the urinary tract. Methenamine hippurate (MH) is non-inferior compared to antibiotic (ABX) prophylaxis to manage recurrent UTI (rUTI) as demonstrated in the clinical trial ALTAR…