1 results for "D. Botman"

The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling

J. van Unen; D. Botman; T. Yin et al.

BMC Cell Biology, Vol. 19 No. 1 · 2018 · English · DOAJ

Abstract Background Rho guanine exchange factors (RhoGEFs) control cellular processes such as migration, adhesion and proliferation. Alternative splicing of the RhoGEF Trio produces TGAT. The RhoGEF TGAT is an oncoprotein with constitutive RhoGEF activity. We investigated whether the subcellular…