9 results for "David A. Springate"

A re-analysis of the Cochrane Library data: the dangers of unobserved heterogeneity in meta-analyses.

Evangelos Kontopantelis; David A Springate; David Reeves

PLoS ONE, Vol. 8 No. 7 · 2013 · English · DOAJ Scopus

BackgroundHeterogeneity has a key role in meta-analysis methods and can greatly affect conclusions. However, true levels of heterogeneity are unknown and often researchers assume homogeneity. We aim to: a) investigate the prevalence of unobserved heterogeneity and the validity of the assumption of…

Also available at: PLOS

Simulation-Based Power Calculations for Mixed Effects Modeling: ipdpower in Stata

Evangelos Kontopantelis; David A Springate; Rosa Parisi et al.

Journal of Statistical Software, Vol. 74 No. 1 · 2016 · English · DOAJ Scopus

Simulations are a practical and reliable approach to power calculations, especially for multi-level mixed effects models where the analytic solutions can be very complex. In addition, power calculations are model-specific and multi-level mixed effects models are defined by a plethora of parameters…

rEHR: An R package for manipulating and analysing Electronic Health Record data.

David A Springate; Rosa Parisi; Ivan Olier et al.

PLoS ONE, Vol. 12 No. 2 · 2017 · English · DOAJ Scopus

Research with structured Electronic Health Records (EHRs) is expanding as data becomes more accessible; analytic methods advance; and the scientific validity of such studies is increasingly accepted. However, data science methodology to enable the rapid searching/extraction, cleaning and analysis…

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ClinicalCodes: an online clinical codes repository to improve the validity and reproducibility of research using electronic medical records.

David A Springate; Evangelos Kontopantelis; Darren M Ashcroft et al.

PLoS ONE, Vol. 9 No. 6 · 2014 · English · DOAJ Scopus

Lists of clinical codes are the foundation for research undertaken using electronic medical records (EMRs). If clinical code lists are not available, reviewers are unable to determine the validity of research, full study replication is impossible, researchers are unable to make effective…

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Modelling Conditions and Health Care Processes in Electronic Health Records: An Application to Severe Mental Illness with the Clinical Practice Research Datalink.

Ivan Olier; David A Springate; Darren M Ashcroft et al.

PLoS ONE, Vol. 11 No. 2 · 2016 · English · DOAJ Scopus

BackgroundThe use of Electronic Health Records databases for medical research has become mainstream. In the UK, increasing use of Primary Care Databases is largely driven by almost complete computerisation and uniform standards within the National Health Service. Electronic Health Records research…

Also available at: PLOS