45 hasil untuk "Dimango, Emily"
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Sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia
PURPOSE: To report a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up. METHODS: Observational case report of one patient. RESULTS: A 31 year-old male with a history of cystic…
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Classic Respiratory Disease but Atypical Diagnostic Testing Distinguishes Adult Presentation of Cystic Fibrosis
BACKGROUND: The majority of new cases of cystic fibrosis (CF) are diagnosed before age 2 years. Diagnoses in older individuals have increased because of improved genetic testing and increased awareness of the disease. A comprehensive description of clinical, genetic, and microbiologic…
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Indoor Allergen Interventions in Homes and Schools for Managing Asthma
Asthma remains a prevalent and burdensome chronic disease in the United States, disproportionately affecting low-income populations and placing a significant strain on the healthcare system. Environmental allergen exposure, particularly in urban areas, has been extensively linked to asthma…
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Chronic Rhinosinusitis in Cystic Fibrosis: Diagnosis and Medical Management
Chronic rhinosinusitis (CRS) is nearly ubiquitous in patients with cystic fibrosis (CF). CF CRS is a challenging entity to define, diagnose, and treat, as patients often have severe refractory sinus disease in addition to complex medical comorbidities. The purpose of this article is to review the…
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Health Disparities among adults cared for at an urban cystic fibrosis program
BACKGROUND: Evidence is conflicting regarding differential health outcomes in racial and ethnic minorities with cystic fibrosis (CF), a rare genetic disease affecting approximately 28,000 Americans. We performed a cross-sectional analysis of health outcomes in Black/Latinx patients compared with…
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Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients
6-Gingerol and 6-shogaol are the most abundant gingerols and shogaols in ginger root and have been shown to reduce the asthmatic phenotype in murine models of asthma. Several studies have described the pharmacokinetics of gingerols and shogaols in humans following the oral ingestion of ginger…
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Low-Dose Oral Ginger Improves Daily Symptom Scores in Asthma
Background/Objective: A significant number of individuals with asthma have poorly controlled daily symptoms and utilize dietary supplements such as ginger in a quest for improved symptom control; however, its effectiveness at improving the control of symptoms is unproven. We questioned whether…
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Effect of esomeprazole versus placebo on pulmonary exacerbations in cystic fibrosis
BACKGROUND: Gastro esophageal reflux (GER) is common in cystic fibrosis (CF) and may contribute to lung disease. Approximately 50% of patients with cystic fibrosis are being treated with proton pump inhibitors (PPIs). METHODS: In a randomized controlled study in adults, we compared treatment with…
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Cystic fibrosis transmembrane conductance regulator attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity
The tumor suppressor PTEN controls cell proliferation by regulating phosphatidylinositol-3-kinase (PI3K) activity, but the participation of PTEN in host defense against bacterial infection is less well understood. Anti-inflammatory PI3K-Akt signaling is suppressed in patients with cystic fibrosis…
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Combined Liver-Lung-Kidney Transplant in a Patient with Cystic Fibrosis
Patient: Male, 23-year-old (7 months at the diagnosis) Final Diagnosis: Cystic fibrosis Symptoms: Cough Medication:— Clinical Procedure: Transplantation Specialty: Pulmonology OBJECTIVE: Unusual clinical course BACKGROUND: Individuals with cystic fibrosis (CF) constituted approximately 10% of organ…
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Abnormal Microarchitecture and Stiffness in Postmenopausal Women Using Chronic Inhaled Glucocorticoids
PURPOSE: While oral glucocorticoids are well recognized to have destructive skeletal effects, less is known about the effects of inhaled glucocorticoids (IGCs). The detrimental skeletal effects of IGCs may be greatest in postmenopausal (PM) women, in whom they compound negative effects of estrogen…
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cFLIP expression is altered in severe corticosteroid-resistant asthma
Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice…
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Effects of Asymptomatic Proximal and Distal Gastroesophageal Reflux on Asthma Severity
Rationale: Silent gastroesophageal reflux (GER) is common in patients with asthma, but it is unclear whether GER is associated with worse asthma symptoms or reduced lung function. Objectives: To determine in patients with poorly controlled asthma, whether proximal or distal esophageal reflux is…
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DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics
BACKGROUND: Asthma is associated with allergic sensitization in about half of all cases, and asthma phenotypes can vary by age and sex. DNA methylation in the promoter of the allergy regulatory gene interferon gamma (IFNγ) has been linked to the maintenance of allergic immune function in human cell…
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Telerehabilitation Using Fitness Application in Patients with Severe Cystic Fibrosis Awaiting Lung Transplant: A Pilot Study
PURPOSE: The purpose of this study was to pilot a home-based pulmonary rehabilitation (PR) program administered via a telemedicine approach using a combination of fitness application and self-selected activity in lung transplant candidates with cystic fibrosis (CF). METHODS: We recruited adult…
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Exploration of Olfaction and ChiPSO in Pediatric Cystic Fibrosis
Background/Objectives: Olfactory dysfunction (OD) is a common symptom among people with cystic fibrosis (PwCF) and contributes to environmental safety concerns, nutritional challenges, and an overall diminished quality of life. OD is perceived to progress along the lifespan in PwCF, often due to…
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Do Patients of Subspecialist Physicians Benefit from Written Asthma Action Plans?
Rationale: Asthma clinical guidelines suggest written asthma action plans are essential for improving self-management and outcomes. Objectives: To assess the efficacy of written instructions in the form of a written asthma action plan provided by subspecialist physicians as part of usual asthma…
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Asthma among hospitalized patients with COVID-19 and related outcomes
BACKGROUND: Several underlying conditions have been associated with severe acute respiratory syndrome coronavirus 2 illness, but it remains unclear whether underlying asthma is associated with worse coronavirus disease 2019 (COVID-19) outcomes. OBJECTIVE: Given the high prevalence of asthma in the…
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A Phase IIa, Single-Blind, Placebo-Controlled, Parallel-Group Study to Assess Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Brensocatib in Adults with Cystic Fibrosis
BACKGROUND AND OBJECTIVES: Brensocatib, an oral, competitive, and reversible inhibitor of dipeptidyl peptidase 1 (DPP1), reduces exacerbations and lung function decline in non-cystic fibrosis bronchiectasis (NCFBE). This study aimed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD)…