1 hasil untuk "Er Lin"

Derlin-1 Regulates Mutant VCP-Linked Pathogenesis and Endoplasmic Reticulum Stress-Induced Apoptosis

Cyong-Jhih Liang; Ya-Chu Chang; Henry C. Chang dkk.

PLoS Genetics, Vol. 10 No. 9 · 2014 · Inggris · PLOS Scopus

Mutations in VCP (Valosin-containing protein), an AAA ATPase critical for ER-associated degradation, are linked to IBMPFD (Inclusion body myopathy with Paget disease and frontotemporal dementia). Using a Drosophila IBMPFD model, we have identified the ER protein Derlin-1 as a modifier of pathogenic…