22 hasil untuk "Fabisiak, Adam"
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Artikel Jurnal Teks lengkap
A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications
Inflammatory bowel diseases (IBD) refer to a group of gastrointestinal (GI) disorders with complex pathogenesis characterized by chronic intestinal inflammation with a variety of symptoms. Cannabinoid and nociceptin opioid receptors (NOPs) and their ligands are widely distributed in the GI tract…
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Artikel Jurnal Teks lengkap
WIN55,212-2 attenuates intestinal fibrosis in a DSS-induced mouse model
BACKGROUND: Inflammatory bowel diseases (IBD) are often associated with intestinal fibrosis. There is increased interest in new methods for managing intestinal fibrosis, among which the endocannabinoid system (ECS) is an interesting therapeutic target. The primary purpose of the study was to…
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Artikel Jurnal Teks lengkap
Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a…
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Purtscher’s-like retinopathy as a rare complication of acute alcoholic pancreatitis
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Artikel Jurnal Teks lengkap
Efficacy, Safety and Future Perspectives of JAK Inhibitors in the IBD Treatment
Although development of biologics has importantly improved the effectiveness in inducing and maintaining remission in inflammatory bowel disease (IBD), biologic therapies still have several limitations. Effective, low-cost drug therapy with good safety profile and compliance is therefore a…
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Artikel Jurnal Teks lengkap
Usefulness of Contrast-Enhanced Ultrasound in the Differentiation between Hepatocellular Carcinoma and Benign Liver Lesions
A differentiation between hepatocellular carcinoma (HCC) and benign liver lesions is required. The aim of the study was to perform an analysis of the time of enhancement of focal liver lesions in a contrast-enhanced ultrasound (CEUS) examination. The curves of enhancement and the homogeneity of the…
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Artikel Jurnal Teks lengkap
The endocannabinoid system as a therapeutic target in intestinal fibrosis
Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases, often leading to strictures that require endoscopic or surgical intervention. Despite advances in anti-inflammatory therapies, effective antifibrotic treatments is currently not available. Therefore, new…
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Artikel Jurnal Teks lengkap
Eosinophilic Esophagitis After Radiofrequency Ablation of Barrett’s Esophagus in a 41-Year-Old Man
Patient: Male, 41-year-old Final Diagnosis: Eosinophilic esophagitis Symptoms: Heartburn • regurgitation Clinical Procedure: Gastroscopy Specialty: Gastroenterology and Hepatology Objective: Rare coexistence of disease or pathology BACKGROUND: Gastroesophageal reflux disease (GERD) and Barrett’s…
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Artikel Jurnal Teks lengkap
Advancements in dual biologic therapy for inflammatory bowel diseases: efficacy, safety, and future directions
Inflammatory bowel diseases (IBDs), primarily encompassing ulcerative colitis and Crohn’s disease, represent a challenging spectrum of disorders with a multifaceted pathogenesis. Despite the array of available treatments, a demand for novel therapeutic options persists to achieve remission in a…
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Artikel Jurnal Teks lengkap
Utility of Contrast-Enhanced Ultrasound in Optimizing Hepatic Abscess Treatment and Monitoring
Background/Objectives: Untreated hepatic abscesses (HAs) have an 80% mortality rate and can be caused by bacteria and fungi. Previously managed with surgery, current treatments now utilize interventional radiology and antibiotics, reducing complications to 2.5%. This study evaluates…
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Artikel Jurnal Teks lengkap
Contrast-enhanced ultrasonography as a method of monitoring focal liver lesions – initial report
AIM OF THE STUDY: Hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) are benign liver tumors. Hepatocellular adenoma has potential for growth, metaplasia and rupture; therefore, it should be monitored long term. In the current guidelines biopsy is not recommended in the standard…
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Artikel Jurnal Teks lengkap
Comparative efficacy of contrast-enhanced ultrasound versus B-mode ultrasound in the diagnosis and monitoring of hepatic abscesses
PURPOSE: This study aimed to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in diagnosing and monitoring hepatic abscesses (HA). MATERIAL AND METHODS: This retrospective study included 29 patients (9 females, 20 males) with 64 HA. Computed tomography (CT) served as the…
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Artikel Jurnal Teks lengkap
Association Between Temporomandibular Disorders and Irritable Bowel Syndrome: A Scoping Review
Temporomandibular disorders (TMDs) encompass various clinical conditions associated with the temporomandibular joint (TMJ) and the masticatory muscles. TMD symptoms include pain in the orofacial region, restricted or altered mandibular movement, and sounds associated with the temporomandibular…
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Artikel Jurnal Teks lengkap
The Expression of F2RL1, P2RX2, P2RX3 and P2RY2 in the Esophagus of Patients with Gastroesophageal Reflux Disease and Their Relationship to Reflux Symptoms—A Pilot Study
Background: The current treatment of gastroesophageal reflux disease (GERD) is focused on decreasing gastric acid secretion. However, there is still a group of patients that do not respond to conventional therapy. Proteinase-activated receptors and purinergic receptors have been implicated in…
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Artikel Jurnal Teks lengkap
Anti-inflammatory and antibacterial effects of human cathelicidin active fragment KR-12 in the mouse models of colitis: a novel potential therapy of inflammatory bowel diseases
INTRODUCTION: Inflammatory bowel diseases (IBD) are a group of chronic gastrointestinal tract disorders with complex etiology, with intestinal dysbiosis as the most prominent factor. In this study, we assessed the anti-inflammatory and antibacterial actions of the human cathelicidin LL-37 and its…
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Artikel Jurnal Teks lengkap
Comparison of ustekinumab, infliximab and combination therapy in moderately to severely active ulcerative colitis – a study protocol of a randomized, multicenter, head-to-head COMBO-UC trial
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a complex etiology that affects the large intestine. Characterized by chronic, bloody diarrhea, UC can lead to severe complications, including an increased risk of colorectal cancer. Despite advancements in…
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Artikel Jurnal Teks lengkap
A Proof-of-Concept Pilot Study of Contrast-Enhanced Ultrasound as a Potential Alternative to Contrast-Enhanced Magnetic Resonance Imaging in the Surveillance of Hepatocellular Adenoma and Focal Nodular Hyperplasia
Background: Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are benign hepatic tumors that predominantly affect women of reproductive age and are associated with hormonal and metabolic factors. While FNH is a non-progressive lesion without malignant potential, HA carries a relevant…
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Artikel Jurnal Teks lengkap
Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice
Diet is considered an important trigger in inflammatory bowel diseases (IBD), as feeding habits can affect intestinal permeability and clearance of bacterial antigens, consequently influencing the immune system. Free fatty acid receptors (FFARs), expressed on the intestinal epithelial cells, belong…
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Artikel Jurnal Teks lengkap
Characterization of the Synergistic Effect between Ligands of Opioid and Free Fatty Acid Receptors in the Mouse Model of Colitis
Background: Recent studies suggest that lipids, including free fatty acids (FFAs), are necessary for proper μ opioid receptor (MOR) binding and that activation of opioid receptors (ORs) improves intestinal inflammation. The objective of the study was to investigate a possible interaction between…