7 hasil untuk "Fu, Yan-Lin"
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Artikel Jurnal Teks lengkap
Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages
Phagocytosis is an essential process for the uptake of large (>0.5 µm) particulate matter including microbes and dying cells. Specialized cells in the body perform phagocytosis which is enabled by cell surface receptors that recognize and bind target cells. Professional phagocytes play a prominent…
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Artikel Jurnal Teks lengkap
LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors
The endoplasmic reticulum-Golgi intermediate compartment protein-53 (ERGIC-53, aka LMAN1), which cycles between the endoplasmic reticulum (ER) and Golgi, is a known cargo receptor for a number of soluble proteins. However, whether LMAN1 plays a role as a trafficking factor in the central nervous…
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Artikel Jurnal Teks lengkap
Combining Valosin-containing Protein (VCP) Inhibition and Suberanilohydroxamic Acid (SAHA) Treatment Additively Enhances the Folding, Trafficking, and Function of Epilepsy-associated γ-Aminobutyric Acid, Type A (GABA(A)) Receptors
GABA(A) receptors are the primary inhibitory ion channels in the mammalian central nervous system. The A322D mutation in the α1 subunit results in its excessive endoplasmic reticulum-associated degradation at the expense of plasma membrane trafficking, leading to autosomal dominant juvenile…
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Artikel Jurnal Teks lengkap
Collision-induced and complex-mediated roaming dynamics in the H + C(2)H(4) → H(2) + C(2)H(3) reaction
Roaming is a novel mechanism in reaction dynamics. It describes an unusual pathway, which can be quite different from the conventional minimum-energy path, leading to products. While roaming has been reported or suggested in a number of unimolecular reactions, it has been rarely reported for…
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Artikel Jurnal Teks lengkap
Remodeling the endoplasmic reticulum proteostasis network restores proteostasis of pathogenic GABA(A) receptors
Biogenesis of membrane proteins is controlled by the protein homeostasis (proteostasis) network. We have been focusing on protein quality control of γ-aminobutyric acid type A (GABA(A)) receptors, the major inhibitory neurotransmitter-gated ion channels in mammalian central nervous system…
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Artikel Jurnal Teks lengkap
Exclusive roaming mechanism for the Cl + C(2)H(2)→C(2)H + HCl bimolecular reaction
The conventional understanding of bimolecular reactions, which either proceed directly via well-defined transition states or pass through potential energy wells, is well-established. However, increasing attention and interest have been drawn to nontraditional reaction pathways, such as roaming…
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Artikel Jurnal Teks lengkap
Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABA(A)) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation
Proteostasis maintenance of γ-aminobutyric acid type A (GABA(A)) receptors dictates their function in controlling neuronal inhibition in mammalian central nervous systems. However, as a multisubunit, multispan, integral membrane protein, even wild type subunits of GABA(A) receptors fold and…