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Curcumin Ameliorates the Reduction Effect of PGE 2 on Fibrillar β-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells

Gen-Lin He; Zhen Luo; Ju Yang dkk.

PLOS ONE, Vol. 11 No. 1 · 2016 · Inggris · PLOS Scopus

Inflammatory activation of microglia and β amyloid (Aβ) deposition are considered to work both independently and synergistically to contribute to the increased risk of Alzheimer’s disease (AD). Recent studies indicate that long-term use of phenolic compounds provides protection against AD…