7 hasil untuk "Gui-Rong Li"

Cholesterol Down-Regulates BK Channels Stably Expressed in HEK 293 Cells

Wei Wu; Yan Wang; Xiu-Ling Deng dkk.

PLoS ONE, Vol. 8 No. 11 · 2013 · Inggris · PLOS Scopus

Cholesterol is one of the major lipid components of the plasma membrane in mammalian cells and is involved in the regulation of a number of ion channels. The present study investigates how large conductance Ca2+-activated K+ (BK) channels are regulated by membrane cholesterol in BK-HEK 293 cells…

Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

Hui-Jun Wu; Hai-Ying Sun; Wei Wu dkk.

PLoS ONE, Vol. 8 No. 3 · 2013 · Inggris · PLOS Scopus

The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (Ito) in human atrial myocytes. However, the molecular determinants of acacetin for blocking Ito are unknown. The present study was designed to investigate the properties and molecular determinants of…

Correction: Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

Hui-Jun Wu; Hai-Ying Sun; Wei Wu dkk.

PLoS ONE, Vol. 8 No. 10 · 2013 · Inggris · PLOS Scopus

Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts

Gui-Rong Li; Hai-Ying Sun; Jing-Bo Chen dkk.

PLoS ONE, Vol. 4 No. 10 · 2009 · Inggris · PLOS Scopus

Background: Although fibroblast-to-myocyte electrical coupling is experimentally suggested, electrophysiology of cardiac fibroblasts is not as well established as contractile cardiac myocytes. The present study was therefore designed to characterize ion channels in cultured human cardiac…

Effects of BK Ca and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit + Progenitor Cells

Ying-Ying Zhang; Gang Li; Hui Che dkk.

PLOS ONE, Vol. 10 No. 9 · 2015 · Inggris · PLOS Scopus

Our previous study demonstrated that a large-conductance Ca2+-activated K+ current (BKCa), a voltage-gated TTX-sensitive sodium current (INa.TTX), and an inward rectifier K+ current (IKir) were heterogeneously present in most of human cardiac c-kit+ progenitor cells. The present study was designed…

Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells

Xiao-Hui Xu; Hai-Ying Sun; Yan-Hui Zhang dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Allitridi (diallyl trisulfide) is an active compound (volatile oil) from garlic. The previous studies reported that allitridi had anti-arrhythmic effect. The potential ionic mechanisms are, however, not understood. The present study was designed to determine the effects of allitridi on cardiac…

Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes

José M. Di Diego; Bence Patocskai; Hector Barajas-Martinez dkk.

PLOS ONE, Vol. 15 No. 11 · 2020 · Inggris · PLOS Scopus

Background: J wave syndromes (JWS), including Brugada (BrS) and early repolarization syndromes (ERS), are associated with increased risk for life-threatening ventricular arrhythmias. Pharmacologic approaches to therapy are currently very limited. Here, we evaluate the effects of the natural flavone…