73 hasil untuk "Guo, Li-Li,"
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Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase
AIM: To examine the protective effects of scutellarin (Scu) on rats with learning and memory deficit induced by β-amyloid peptide (Aβ). METHODS: Fifty male Wistar rats were randomly divided into 5 groups: control, sham operation, Aβ, Aβ+Scu, and Aβ+piracetam groups. Aβ(25–35) was injected into the…
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Pharmacokinetic/pharmacodynamic (PK/PD) evaluation of tulathromycin against Haemophilus parasuis in an experimental neutropenic guinea pig model
The objective of the study was to develop an ex-vivo PK/PD model of intramuscular (IM) administration of tulathromycin and to test its efficacy against Haemophilus parasuis (H. parasuis) infection in intraperitoneal-inoculated neutropenic guinea pigs. The pharmacokinetics (PKs) of tulathromycin at…
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In Vivo Corneal Biomechanical Properties in a Selected Chinese Population, Measured Using the Corneal Visualization Scheimpflug Technology
Purpose: To evaluate the repeatability and reproducibility of recalculated dynamic corneal response (DCR) parameters and the biomechanical-compensated intraocular pressure (bIOP) derived from the Corneal Visualization Scheimpflug Technology (Corvis ST), as well as to study the variations of DCR…
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Age-related analysis of corneal biomechanical parameters in healthy Chinese individuals
To report the correlation between corneal biomechanical parameters and age in healthy Chinese individuals. This cross-sectional study was conducted on 864 eyes of 543 healthy participants. A comprehensive ophthalmic examination and corneal biomechanics examination using Corneal Visualization…
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TFAP2A induces cisplatin resistance via BNIP3-mediated mitophagy in non-small cell lung cancer
BACKGROUND: Cisplatin resistance in non-small cell lung cancer (NSCLC) significantly limits treatment efficacy. Mitophagy has been shown to play a protective role in cisplatin resistance. This study aims to further investigate the mechanisms underlying this process, with a particular focus on…
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Ethyl 6-(4-fluorophenyl)-4-hydroxy-2-oxo-4-trifluoromethyl-1,3-diazinane-5-carboxylate monohydrate
The asymmetric unit of the title compound, C(14)H(14)F(4)N(2)O(4)·H(2)O, contains two crystallographically independent organic molecules and two water molecules. The two 1,3-diazinane rings adopt a half-chair conformation and the dihedral angles between their mean planes and those of the benzene…
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Cortical plasticity between the pain and pain-free phases in patients with episodic tension-type headache
BACKGROUND: State-related brain structural alterations in patients with episodic tension-type headache (ETTH) are unclear. We aimed to conduct a longitudinal study to explore dynamic gray matter (GM) changes between the pain and pain-free phases in ETTH. METHODS: We recruited 40 treatment-naïve…
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Effects of monosulfuron-ester on metabolic processes of nitrogen-fixing cyanobacteria Anabaena flos-aquae and Anabaena azotica
Presence of the relatively new sulfonylurea herbicide monosulfuron-ester at 0.03–300 nmol/L affected the growth of two non-target nitrogen-fixing cyanobacteria (Anabaena flos-aquae and Anabaena azotica) and substantially inhibited in vitro Acetolactate synthase activity, with IC(50) of 3.3 and…
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Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of…
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[20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe
Twelve new lanostane triterpenoids (1–5, 7–13) were isolated from the fruiting bodies of the fungus Ganoderma australe. The structures of the new compounds were elucidated by extensive 1D and 2D NMR, and HRESIMS spectroscopic analysis. All the triterpenes are featured by 20(22)E configurations…
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Predicting Gene Comutation of EGFR and TP53 by Radiomics and Deep Learning in Patients With Lung Adenocarcinomas
PURPOSE: This study was designed to construct progressive binary classification models based on radiomics and deep learning to predict the presence of epidermal growth factor receptor (EGFR) and TP53 mutations and to assess the models’ capacities to identify patients who are suitable for…
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Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome
AIM: To investigate the activity of vesicular glutamate transporter-3 (VGLUT3) in a visceral hyperalgesia rat model of irritable bowel syndrome, and the role of mast cells (MCs). METHODS: Transient intestinal infection was induced by oral administration of Trichinella spiralis larvae in rats. On…
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Comparison of the clinical application value of mo-targeted X-ray, color doppler ultrasound and MRI in preoperative comprehensive evaluation of breast cancer
OBJECTIVE: To investigate the clinical application value of the Mo-targeted X-ray examination, color Doppler ultrasound and magnetic resonance imaging (MRI) in the diagnosis and preoperative comprehensive evaluation of breast cancer. METHODS: Among 170 breast cancer patients, they underwent…
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Prediction of pathological activity in Crohn’s disease based on dual-energy CT enterography
PURPOSE: To explore the feasibility of predicting the pathological activity of Crohn’s disease (CD) based on dual-energy CT enterography (DECTE). METHODS: The clinical, endoscopic, imaging and pathological data of 55 patients with CD scanned by DECTE were retrospectively analyzed; the pathological…
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Prediction of histopathological grade in gastric cancer using dual energy CT-derived synthetic extracellular volume fraction
PURPOSE: To investigate the relationship between the synthetic extracellular volume (ECV) fraction and the hematocrit (HCT)-based ECV fraction in gastric cancer patients and to evaluate its potential utility in predicting the pathological grade of gastric cancer. METHODS: Data from the derivation…
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Enhanced recovery after surgery in laparoscopic radical gastrectomy for gastric cancer: efficacy, safety, meta-analysis
OBJECTIVE: To systematically evaluate the efficacy and safety of enhanced recovery after surgery (ERAS) involving laparoscopic radical gastrectomy for gastric cancer (GC). METHODS: A systematic literature search was conducted across four English databases (PubMed, the Cochrane Library, EMBASE, Web…
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A pair epimers of eremophilane sesquiterpene from
Two oxygenated eremophilane-type sesquiterpenoids, possessing C 21 skeleton, a pair epimers, have been isolated from the whole plants of Ligularia macrophylla (Compositae). Their structures were determined by analysis of infrared, ultraviolet, nuclear magnetic resonance, high-resolution…
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Integrin-linked kinase in gastric cancer cell attachment, invasion and tumor growth
AIM: To investigate the effects of integrin-linked kinase (ILK) on gastric cancer cells both in vitro and in vivo. METHODS: ILK small interfering RNA (siRNA) was transfected into human gastric cancer BGC-823 cells and ILK expression was monitored by real-time quantitative polymerase chain reaction…
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Recombinant adenovirus expressing a dendritic cell-targeted melanoma surface antigen for tumor-specific immunotherapy in melanoma mice model
Viral vectors represent a potential strategy for the treatment of human malignant tumors. Currently, recombinant adenovirus vectors are commonly used as gene therapy vehicles, as it possesses a proven safety profile in normal human cells. The recombinant adenovirus system has an ability to highly…
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Epigenetic silencing of olfactomedin-4 enhances gastric cancer cell invasion via activation of focal adhesion kinase signaling
Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell…