8 hasil untuk "Guo Lin"

Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer

Guo-Lin Chen; Gregory M. Miller

PLoS ONE, Vol. 8 No. 4 · 2013 · Inggris · PLOS Scopus

The repressor element silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice variant REST4 has been linked to various types of cancer. We performed a…

Correction: Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer

Guo-Lin Chen; Gregory M. Miller

PLoS ONE, Vol. 9 No. 1 · 2014 · Inggris · PLOS Scopus

Signal of Acceleration and Physical Mechanism of Water Cycle in Xinjiang, China

Guo-Lin Feng; Yong-Ping Wu

PLOS ONE, Vol. 11 No. 12 · 2016 · Inggris · PLOS Scopus

Global warming accelerates water cycle with features of regional difference. However, little is known about the physical mechanism behind the phenomenon. To reveal the links between water cycle and climatic environment, we analyzed the changes of water cycle elements and their relationships with…

Association between Estrogen Receptor α Gene ( ESR1 ) PvuII (C/T) and XbaI (A/G) Polymorphisms and Hip Fracture Risk: Evidence from a Meta-Analysis

Li Tang; Guo-Lin Cheng; Zhong-Hua Xu

PLoS ONE, Vol. 8 No. 12 · 2013 · Inggris · PLOS Scopus

Background and Objective: Genetic factors are important in the pathogenesis of fractures. Notably, estrogen receptor α (ESR1) has been suggested as a possible candidate gene for hip fractures; however, published studies of ESR1 gene polymorphisms have been hampered by small sample sizes and…

The Impact of Compact Layer in Biphasic Scaffold on Osteochondral Tissue Engineering

Hu Da; Shuai-Jun Jia; Guo-Lin Meng dkk.

PLoS ONE, Vol. 8 No. 1 · 2013 · Inggris · PLOS Scopus

The structure of an osteochondral biphasic scaffold is required to mimic native tissue, which owns a calcified layer associated with mechanical and separation function. The two phases of biphasic scaffold should possess efficient integration to provide chondrocytes and osteocytes with an…

Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro

Yuan Yuan; Zhe Sun; Yi Chen dkk.

PLOS ONE, Vol. 12 No. 2 · 2017 · Inggris · PLOS Scopus

Remifentanil-induced secondary hyperalgesia has been demonstrated in both animal experiments and clinical trials. Enhancement of N-methyl-D-aspartate (NMDA) receptor trafficking as well as protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMKII) have been reported to be involved…

Effect of different origins on genes encoding key enzymes involved in the polysaccharide biosynthetic pathway in Hedysarum polybotrys Hand.-Mazz.

Zi Xia Wang; Hui Ni Yang; Yan Ping Wang dkk.

PLOS One, Vol. 20 No. 4 · 2025 · Inggris · PLOS Scopus

Radix Hedysari (HP) is a traditional Chinese medicine that has gained widespread attention for its tonic effects. Environmental factors significantly influence the active components in HP, notably Radix Hedysari polysaccharides (HPS), which are the principal active constituents. To date, no studies…

Protection by Salidroside against Bone Loss via Inhibition of Oxidative Stress and Bone-Resorbing Mediators

Jin-Kang Zhang; Liu Yang; Guo-Lin Meng dkk.

PLoS ONE, Vol. 8 No. 2 · 2013 · Inggris · PLOS Scopus

Oxidative stress is a pivotal pathogenic factor for bone loss in mouse model. Salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea L, exhibits potent antioxidative effects. In the present study, we used an in vitro oxidative stress model induced by hydrogen peroxide (H2O2) in…