16 hasil untuk "Gupta, Deepesh Kumar"
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Artikel Jurnal Teks lengkap
Dental implant survival in diabetic patients; review and recommendations
Rising population of diabetic individuals across the world has become a big concern to the society. The persistent hyperglycemia may affect each and every tissue and consequently results in morbidity and eventually mortality in diabetic patients. A direct negative response of diabetes has been…
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Tension-induced cytokinetic abscission in human fibroblasts
Previous studies have shown that cytokinetic abscission at the end of mitosis is executed by the ESCRT machinery in mammalian cells, and that the process is dependent on adhesion-induced integrin signalling via a FAK-PLK1-CEP55-TSG101/Alix-CHMP4B pathway. The present study identified an alternative…
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Artikel Jurnal Teks lengkap
Side effects of metal-based dental implantology treatment - A review
Titanium dental implants are widely used for their biocompatibility and mechanical strength but are vulnerable to corrosion within the oral environment. Corrosive processes such as galvanic, pitting, crevice and fretting corrosion are influenced by salivary pH, fluoride concentration, bacterial…
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Septin and Ras regulate cytokinetic abscission in detached cells
BACKGROUND: Integrin-mediated adhesion is normally required for cytokinetic abscission, and failure in the process can generate potentially oncogenic tetraploid cells. Here, detachment-induced formation of oncogenic tetraploid cells was analyzed in non-transformed human BJ fibroblasts and BJ…
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Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody
Adhesion to extracellular matrix is required for cell cycle progression through the G1 phase and for the completion of cytokinesis in normal adherent cells. Cancer cells acquire the ability to proliferate anchorage-independently, a characteristic feature of malignantly transformed cells. However…
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Artikel Jurnal Teks lengkap
Oral health awareness: Periodontitis among diabetic patients in Chhattisgarh, India
Awareness on diabetes-periodontitis association among 300 patients (150 diabetic, 150 non-diabetic) attending a tertiary care center in Chhattisgarh is of interest. Only 36% of diabetic participants recognized this link, while 76% of all respondents were unaware of the systemic impact of poor oral…
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Artikel Jurnal Teks lengkap
Dental awareness among pregnant and non-pregnant women in Chhattisgarh
A dental awareness, knowledge and oral hygiene practice among 77 pregnant and 77 non-pregnant women in Chhattisgarh is of interest. A significant lack of awareness was observed, with 100% of non-pregnant and 96.1% of pregnant women not prioritizing routine dental visits and only 3.9% of pregnant…
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Artikel Jurnal Teks lengkap
Integrin-Mediated Adhesion Promotes Centrosome Separation in Early Mitosis
Integrin-mediated adhesion to the extracellular matrix is a key regulator of the cell cycle, as demonstrated for the passage of the G1/S checkpoint and the completion of cytokinetic abscission. Here, integrin-dependent regulation of the cell cycle in G2 and early M phases was investigated. The…
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Comparative evaluation of marginal fit accuracy of two different designs of endocrown manufactured through CAD-CAM system: An in vitro study
AIMS: To compare the accuracy of marginal fit of CAD-CAM endocrown with two different preparation forms, i.e., endocrown with ferrule and endocrown without ferrule. SETTINGS AND DESIGN: Various studies have opined on the impact of preparation form on the marginal fit of endocrown, but studies on…
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Artikel Jurnal Teks lengkap
The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I
The meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes. TERB1 has an MYB-like DNA-binding (MYB) domain, which is a hallmark of telomeric DNA-binding proteins. Here, we demonstrate that…
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Rational protein engineering to enhance MHC-independent T cell receptors
Chimeric antigen receptor (CAR)-based therapies have pioneered synthetic cellular immunity but remain limited in their long-term efficacy. Emerging data suggest that dysregulated CAR-driven T cell activation causes T cell dysfunction and therapeutic failure. To re-engage the precision of the…
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Artikel Jurnal Teks lengkap
Transcriptional analysis of primary ciliary dyskinesia airway cells reveals a dedicated cilia glutathione pathway
Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia. The repercussions of cilia dysmotility and gene variants on the multiciliated cell remain poorly understood. We used single-cell RNA-Seq, proteomics, and advanced microscopy to compare primary culture…
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Artikel Jurnal Teks lengkap
The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes
DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown. We used CRISPR-Cas9 genome editing in mice to recreate a human…
Juga tersedia di: PubMed Central
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Artikel Jurnal Teks lengkap
BACH2 regulates T cell lineage state to enhance CAR T cell function
Nearly all chimeric antigen receptors (CARs) signal in the absence of antigen, referred to as ‘tonic signaling’. Tonic signaling of CARs containing 41BB domains enhances T cell fitness and function, in contrast to the exhaustion driven by CD28-containing CARs. Here we show that 41BB induces BACH2…