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3 results for "Hemanth Kumar"

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  1. Journal Article Full text

    Sub-therapeutic nevirapine concentration during antiretroviral treatment initiation among children living with HIV: Implications for therapeutic drug monitoring

    Bindu Parachalil Gopalan; Kayur Mehta; Reena R. D'souza et al.

    PLOS ONE, Vol. 12 No. 8 · 2017 · English · PLOS Scopus

    Nevirapine, a component of antiretroviral therapy (ART) in resource-limited settings, known for auto-induction of metabolism, is initiated at half therapeutic dose until day 14 (‘lead-in period’), and subsequently escalated to full dose. However, studies have shown that this dosing strategy based…

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  2. Journal Article Full text

    Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

    Vidya Mave; Aarti Kinikar; Anju Kagal et al.

    PLOS ONE, Vol. 12 No. 12 · 2017 · English · PLOS Scopus

    We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among…

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  3. Journal Article Full text

    In-vivo studies on Transitmycin, a potent Mycobacterium tuberculosis inhibitor

    Rajesh Mondal; Azger Dusthackeer V. N.; Palaniyandi Kannan et al.

    PLOS ONE, Vol. 18 No. 3 · 2023 · English · PLOS Scopus

    This study involves the in-vitro and in-vivo anti-TB potency and in-vivo safety of Transitmycin (TR) (PubChem CID:90659753)- identified to be a novel secondary metabolite derived from Streptomyces sp (R2). TR was tested in-vitro against drug resistant TB clinical isolates (n = 49). 94% of DR-TB…

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