6 results for "Heming Wang"

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

Ya-Juan Wang; Bamidele O. Tayo; Anupam Bandyopadhyay et al.

PLoS Genetics, Vol. 10 No. 9 · 2014 · English · PLOS Scopus

High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)–rs2272996–in the gene encoding vanin-1, a glycosylphosphatidylinositol…

Rare variants in fox-1 homolog A ( RBFOX1 ) are associated with lower blood pressure

Karen Y. He; Heming Wang; Brian E. Cade et al.

PLOS Genetics, Vol. 13 No. 3 · 2017 · English · PLOS Scopus

Many large genome-wide association studies (GWAS) have identified common blood pressure (BP) variants. However, most of the identified BP variants do not overlap with the linkage evidence observed from family studies. We thus hypothesize that multiple rare variants contribute to the observed…

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

Sung Chun; Sebastian Akle; Athanasios Teodosiadis et al.

PLOS Genetics, Vol. 18 No. 12 · 2022 · English · PLOS Scopus

Genetic association studies of many heritable traits resulting from physiological testing often have modest sample sizes due to the cost and burden of the required phenotyping. This reduces statistical power and limits discovery of multiple genetic associations. We present a strategy to leverage…

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

Brian E. Cade; Han Chen; Adrienne M. Stilp et al.

PLOS Genetics, Vol. 15 No. 4 · 2019 · English · PLOS Scopus

Sleep disordered breathing (SDB)-related overnight hypoxemia is associated with cardiometabolic disease and other comorbidities. Understanding the genetic bases for variations in nocturnal hypoxemia may help understand mechanisms influencing oxygenation and SDB-related mortality. We conducted…

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

Jingjing Liang; Thu H. Le; Digna R. Velez Edwards et al.

PLOS Genetics, Vol. 13 No. 5 · 2017 · English · PLOS Scopus

Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and…

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

Jingjing Liang; Thu H. Le; Digna R. Velez Edwards et al.

PLOS Genetics, Vol. 14 No. 5 · 2018 · English · PLOS Scopus