68 hasil untuk "Howe, Philip"

Neuropathy after Thalidomide (“Distaval”)

Howe, Philip

Br Med J · 1961 · Inggris · PubMed Central

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The Tale of Transforming Growth Factor-β (TGFβ) Signaling: A Soigné Enigma

Chaudhury, Arindam; Howe, Philip H.

IUBMB Life · 2009 · Inggris · PubMed Central

Transforming growth factor-beta (TGFβ) is a secreted cytokine, which intricately controls a plethora of physiological and pathological processes during development and carcinogenesis. TGFβ exerts antiproliferative effects and functions as a tumor suppressor during early stages of tumorigenesis…

hnRNP E1 at the crossroads of translational regulation of epithelial-mesenchymal transition

Grelet, Simon; Howe, Philip H.

J Cancer Metastasis Treat · 2019 · Inggris · PubMed Central

The epithelial-mesenchymal transition (EMT), in which cells undergo a switch from a polarized, epithelial phenotype to a highly motile fibroblastic or mesenchymal phenotype is fundamental during embryonic development and can be reactivated in a variety of diseases including cancer…

ELISA-Based Enzyme Kinetics Assay for Measuring cGAS Activity

Fréreux, Cécile; Howe, Philip H.

Bio Protoc · 2026 · Inggris · PubMed Central

Cyclic GMP–AMP synthase (cGAS) is a key cytosolic double-stranded DNA sensor that activates innate immune responses. Upon binding double-stranded DNA, cGAS undergoes conformational activation and catalyzes the synthesis of the second messenger 2′3′-cyclic GMP–AMP (2′3′-cGAMP) from ATP and GTP…

Runx1 Is a Co-activator with FOXO3 to Mediate Transforming Growth Factor β (TGFβ)-induced Bim Transcription in Hepatic Cells

Wildey, Gary M.; Howe, Philip H.

J Biol Chem · 2009 · Inggris · PubMed Central

Transforming growth factor β (TGFβ) regulates essential cellular functions such as cellular proliferation, differentiation, and apo pto sis. The Bcl-2 family of proteins has been implicated as mediators of TGFβ-induced apo pto sis. We demonstrated previously that TGFβ induces the expression of Bim…

Traumatic fracture of central venous catheter resulting in potential migration of distal fragment: a case report

Deep, Shailendra; Deshpande, Sanjay; Howe, Philip

Cases J · 2008 · Inggris · PubMed Central

We report a surgical retrieval of an indwelling portion of a traumatic rupture of the Central venous catheter following hair cutting by a confused patient secondary to Postoperative cognitive dysfunction. He had a dynamic compression screw for fixation of fractured neck of femur after previously…

TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1

Howley, Breege V; Howe, Philip H

Cytokine · 2018 · Inggris · PubMed Central

The TGFβ signaling pathway is a critical regulator of cancer progression in part through induction of the epithelial to mesenchymal transition (EMT). This process is aberrantly activated in cancer cells, facilitating invasion of the basement membrane, survival in the circulatory system, and…

Metastasis-associated upregulation of ER-Golgi trafficking kinetics: regulation of cancer progression via the Golgi apparatus

Howley, Breege V.; Howe, Philip H.

Oncoscience · 2018 · Inggris · PubMed Central

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

Jiang, Yong; He, Xi; Howe, Philip H

EMBO J · 2012 · Inggris · PubMed Central

Canonical Wnt signalling requires caveolin-dependent internalization of low-density lipoprotein receptor-related protein 6 (LRP6). Here we report that the tumour suppressor and endocytic adaptor disabled-2 (Dab2), previously described as an inhibitor of Wnt/β-catenin signalling, selectively…

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles

Chaudhury, Arindam; Chander, Praveen; Howe, Philip H.

RNA · 2010 · Inggris · PubMed Central

Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a family of RNA-binding proteins. The complexity and diversity associated with the hnRNPs render them multifunctional, involved not only in processing heterogeneous nuclear RNAs (hnRNAs) into mature mRNAs, but also acting as trans-factors…

EMT does not work regular shifts

Grelet, Simon; Geslain, Renaud; Howe, Philip H.

Cell Cycle · 2018 · Inggris · PubMed Central

Transforming growth factor β (TGFβ)-induced apoptosis

Ramesh, Sneha; Wildey, Gary M.; Howe, Philip H.

Cell Cycle · 2009 · Inggris · PubMed Central

Transforming growth factor β (TGFβ) regulates essential cellular functions such as cellular proliferation, differentiation and apoptosis. Multiple apoptotic mediators and signaling pathways have been implicated in TGFβ-induced apoptosis. Bim, a BH3-only protein, is critical for apoptosis in a…

3′-UTR-mediated post-transcriptional regulation of cancer metastasis

Chaudhury, Arindam; Hussey, George S; Howe, Philip H

RNA Biol · 2011 · Inggris · PubMed Central

Epithelial-mesenchymal transition (EMT) and the underlying mechanisms and signaling pathways regulating such transitions have generated a lot of interest among cancer researchers. Much of this can be attributed to the apparent similarities in the molecular processes regulating embryonic EMT that…

Disabled-2; an autophagic and apoptotic switch

Jiang, Yong; Woosley, Alec N.; Howe, Philip H.

Cell Cycle · 2016 · Inggris · PubMed Central

ARIH1 Inhibition Promotes Microtubule Stability and Sensitizes Breast Cancer Cells to Microtubule-Stabilizing Agents

Elshaer, Mohamed; Howley, Breege V.; Howe, Philip H.

Cancers (Basel) · 2025 · Inggris · PubMed Central

Background: Microtubule dynamics play a pivotal role in cancer progression and response to chemotherapeutics. Identifying regulators of microtubule stability can provide new therapeutic targets and predictive biomarkers for cancer treatment. Methods: We investigated the role of ARIH1, an E3…

Identification and characterization of an hnRNP E1 translational silencing motif

Brown, Andrew S.; Mohanty, Bidyut K.; Howe, Philip H.

Nucleic Acids Res · 2016 · Inggris · PubMed Central

Non-canonical transforming growth factor β (TGFβ) signaling through protein kinase B (Akt2) induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1). This post-translational modification (PTM) of hnRNP E1 promotes its dissociation from a 3′…

Post-transcriptional mapping reveals critical regulators of metastasis

Hussey, George S.; Howley, Breege V.; Howe, Philip H.

Oncoscience · 2015 · Inggris · PubMed Central

Pleiotropic Roles of Non-Coding RNAs in TGF-β-Mediated Epithelial-Mesenchymal Transition and Their Functions in Tumor Progression

Grelet, Simon; McShane, Ariel; Geslain, Renaud dkk.

Cancers (Basel) · 2017 · Inggris · PubMed Central

Epithelial-mesenchymal transition (EMT) is a spatially- and temporally-regulated process involved in physiological and pathological transformations, such as embryonic development and tumor progression. While the role of TGF-β as an EMT-inducer has been extensively documented, the molecular…

Computational Identification of Post Translational Modification Regulated RNA Binding Protein Motifs

Brown, Andrew S.; Mohanty, Bidyut K.; Howe, Philip H.

PLoS One · 2015 · Inggris · PubMed Central

RNA and its associated RNA binding proteins (RBPs) mitigate a diverse array of cellular functions and phenotypes. The interactions between RNA and RBPs are implicated in many roles of biochemical processing by the cell such as localization, protein translation, and RNA stability. Recent discoveries…