97 hasil untuk "Hui Lin"
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Artikel Jurnal Teks lengkap
Experimental Evolution of Trichoderma citrinoviride for Faster Deconstruction of Cellulose
Engineering faster cellulose deconstruction is difficult because it is a complex, cooperative, multi-enzyme process. Here we use experimental evolution to select for populations of Trichoderma citrinoviride that deconstruct up to five-fold more cellulose. Ten replicate populations of T…
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The Arg233Lys AQP0 Mutation Disturbs Aquaporin0-Calmodulin Interaction Causing Polymorphic Congenital Cataract
Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium dependent manner to regulate the water permeability of AQP0. We previously identified a missense mutation (p.R233K) in the putative CaM binding domain of AQP0 C-terminus in a congenital cataract family. This…
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Growth Hormone Promotes Hair Cell Regeneration in the Zebrafish ( Danio rerio ) Inner Ear following Acoustic Trauma
Background: Previous microarray analysis showed that growth hormone (GH) was significantly upregulated following acoustic trauma in the zebrafish (Danio rerio) ear suggesting that GH may play an important role in the process of auditory hair cell regeneration. Our objective was to examine the…
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Quantification Bias Caused by Plasmid DNA Conformation in Quantitative Real-Time PCR Assay
Quantitative real-time PCR (qPCR) is the gold standard for the quantification of specific nucleic acid sequences. However, a serious concern has been revealed in a recent report: supercoiled plasmid standards cause significant over-estimation in qPCR quantification. In this study, we investigated…
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A Repeat Sequence Causes Competition of ColE1-Type Plasmids
Plasmid pSW200 from Pantoea stewartii contains 41 copies of 15-bp repeats and has a replicon that is homologous to that of ColE1. Although deleting the repeats (pSW207) does not change the copy number and stability of the plasmid. The plasmid becomes unstable and is rapidly lost from the host when…
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Benefits of Therapeutic Drug Monitoring of Vancomycin: A Systematic Review and Meta-Analysis
Background and Objective: The necessity of therapeutic drug monitoring (TDM) for vancomycin is controversial. The objective of the current review was to evaluate the available evidence for the necessity of TDM in patients given vancomycin to treat Gram-positive infections. Methods: Medline, Embase…
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The Inner Nuclear Membrane Protein Src1 Is Required for Stable Post-Mitotic Progression into G1 in Aspergillus nidulans
How membranes and associated proteins of the nuclear envelope (NE) are assembled specifically and inclusively around segregated genomes during exit from mitosis is incompletely understood. Inner nuclear membrane (INM) proteins play key roles by providing links between DNA and the NE. In this study…
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Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis
Background and Objective: The association between the CYP3A4*1B single nucleotide polymorphism (SNP) and tacrolimus pharmacokinetics in different studies is controversial. Therefore, a meta-analysis was employed to evaluate the correlation between the CYP3A4*1B genetic polymorphism and tacrolimus…
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Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells
Transforming growth factor-β (TGF-β), via its receptors, induces epithelial-mesenchymal transition (EMT) and plays an important role in the development of renal tubulointersitial fibrosis. Angiotensin II type 2 receptor (AT2R), which mediates beneficial renal physiological functions, has received…
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Artikel Jurnal Teks lengkap
The development of the own-race advantage in school-age children: A morphing face paradigm
Previous studies examining the other-race effect in school-age children mostly focused on recognition memory performance. Here we investigated perceptual discriminability for Asian-like versus Caucasian-like morph faces in school-age Taiwanese children and adults. One-hundred-and-two 5- to…
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Analyzing the ecological relations of technology innovation of the Chinese high-tech industry based on the Lotka-Volterra model
Technology innovation has become an important driving force of economic and social development and has received wide attention from academics. Most scholars mainly take technology innovation as an overall variable to explore its impact on the economy and society. The main contribution of this study…
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Mapping and dynamic monitoring of desertification on the Qinghai-Tibetan Plateau using surface Albedo and Solar-Induced Chlorophyll Fluorescence
Desertification poses a significant threat to humanity’s long-term survival and sustainable development. In this study, four types of 2D desertification assessment models were created by integrating surface albedo with four vegetation-related indicators: NDVI, MSAVI, EVI, and solar-induced…
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HP1a Targets the Drosophila KDM4A Demethylase to a Subset of Heterochromatic Genes to Regulate H3K36me3 Levels
The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However, the genome-wide distribution of KDM4…
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Stability and Synchronization for Discrete-Time Complex-Valued Neural Networks with Time-Varying Delays
In this paper, the synchronization problem for a class of discrete-time complex-valued neural networks with time-varying delays is investigated. Compared with the previous work, the time delay and parameters are assumed to be time-varying. By separating the real part and imaginary part, the…
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Artikel Jurnal Teks lengkap
IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse
Osteoporosis is one of the most prevalent skeletal system diseases. It is characterized by a decrease in bone mass and microarchitectural changes in bone tissue that lead to an attenuation of bone resistance and susceptibility to fracture. Vertebral fracture is by far the most prevalent…
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Efficacy and safety of saxagliptin in patients with type 2 diabetes: A systematic review and meta-analysis
Objective: To evaluate the comparative efficacy and safety of saxagliptin for type 2 diabetes (T2D). Methods: A systematic search of PubMed, Embase, the Cochrane Library, Web of Science, ClinicalTrials.gov and two Chinese databases for randomized controlled trials (RCTs) comparing saxagliptin with…
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Artikel Jurnal Teks lengkap
High-Throughput Sequencing of Microbial Community Diversity and Dynamics during Douchi Fermentation
Douchi is a type of Chinese traditional fermented food that is an important source of protein and is used in flavouring ingredients. The end product is affected by the microbial community present during fermentation, but exactly how microbes influence the fermentation process remains poorly…
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A secretory phospholipase D hydrolyzes phosphatidylcholine to suppress rice heading time
Phospholipase D (PLD) hydrolyzes membrane phospholipids and is crucial in various physiological processes and transduction of different signals. Secretory phospholipases play important roles in mammals, however, whose functions in plants remain largely unknown. We previously identified a rice…
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Persistent Hepatitis B Viral Replication in a FVB/N Mouse Model: Impact of Host and Viral Factors
The mechanism underlying the chronicity of hepatitis B virus (HBV) infection has long been an interesting question. However, this mechanism remains unclear largely due to the lack of an animal model that can support persistent HBV replication and allow for the investigation of the relevant immune…
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Artikel Jurnal Teks lengkap
Involvement of Iron in Biofilm Formation by Staphylococcus aureus
Staphylococcus aureus is a human pathogen that forms biofilm on catheters and medical implants. The authors' earlier study established that 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) inhibits biofilm formation by S. aureus by preventing the initial attachment of the cells to a solid surface…