98 hasil untuk "Intes, Xavier"
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Artikel Jurnal Teks lengkap
Adaptive wide-field optical tomography
We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through…
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Comparison of Monte Carlo methods for fluorescence molecular tomography—computational efficiency
Purpose: The Monte Carlo method is an accurate model for time-resolved quantitative fluorescence tomography. However, this method suffers from low computational efficiency due to the large number of photons required for reliable statistics. This paper presents a comparison study on the…
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Dental optical tomography with upconversion nanoparticles—a feasibility study
Upconversion nanoparticles (UCNPs) have the unique ability to emit multiple colors upon excitation by near-infrared (NIR) light. Herein, we investigate the potential use of UCNPs as contrast agents for dental optical tomography, with a focus on monitoring the status of fillings after dental…
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Time-gated perturbation Monte Carlo for whole body functional imaging in small animals
This paper explores a time-resolved functional imaging method based on Monte Carlo model for whole-body functional imaging of small animals. To improve the spatial resolution and quantitative accuracy of the functional map, a Bayesian hierarchical method with a high resolution spatial prior is…
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Mesh Optimization for Monte Carlo-Based Optical Tomography
Mesh-based Monte Carlo techniques for optical imaging allow for accurate modeling of light propagation in complex biological tissues. Recently, they have been developed within an efficient computational framework to be used as a forward model in optical tomography. However, commonly employed…
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Mesh-based Monte Carlo method in time-domain widefield fluorescence molecular tomography
We evaluated the potential of mesh-based Monte Carlo (MC) method for widefield time-gated fluorescence molecular tomography, aiming to improve accuracy in both shape discretization and photon transport modeling in preclinical settings. An optimized software platform was developed utilizing…
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Monte Carlo based method for fluorescence tomographic imaging with lifetime multiplexing using time gates
Time-resolved fluorescence optical tomography allows 3-dimensional localization of multiple fluorophores based on lifetime contrast while providing a unique data set for improved resolution. However, to employ the full fluorescence time measurements, a light propagation model that accurately…
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Development of an optical imaging platform for functional imaging of small animals using wide-field excitation
The design and characterization of a time-resolved functional imager using a wide-field excitation scheme for small animal imaging is described. The optimal operation parameters are established based on phantom studies. The performance of the platform for functional imaging and the simultaneous 3D…
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Hyperspectral wide-field time domain single-pixel diffuse optical tomography platform
We present the design and comprehensive instrumental characterization of a time domain diffuse optical tomography (TD-DOT) platform based on wide-field illumination and wide-field hyperspectral time-resolved single-pixel detection for functional and molecular imaging in turbid media. The proposed…
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Direct approach to compute Jacobians for diffuse optical tomography using perturbation Monte Carlo-based photon “replay”
Perturbation Monte Carlo (pMC) has been previously proposed to rapidly recompute optical measurements when small perturbations of optical properties are considered, but it was largely restricted to changes associated with prior tissue segments or regions-of-interest. In this work, we expand pMC to…
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Generalized mesh-based Monte Carlo for wide-field illumination and detection via mesh retessellation
Monte Carlo methods are commonly used as the gold standard in modeling photon transport through turbid media. With the rapid development of structured light applications, an accurate and efficient method capable of simulating arbitrary illumination patterns and complex detection schemes over large…
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Wide-field fluorescence molecular tomography with compressive sensing based preconditioning
Wide-field optical tomography based on structured light illumination and detection strategies enables efficient tomographic imaging of large tissues at very fast acquisition speeds. However, the optical inverse problem based on such instrumental approach is still ill-conditioned. Herein, we…
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Temporal Data Set Reduction Based on D-Optimality for Quantitative FLIM-FRET Imaging
Fluorescence lifetime imaging (FLIM) when paired with Förster resonance energy transfer (FLIM-FRET) enables the monitoring of nanoscale interactions in living biological samples. FLIM-FRET model-based estimation methods allow the quantitative retrieval of parameters such as the quenched…
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Optical tomographic imaging for breast cancer detection
Diffuse optical breast imaging utilizes near-infrared (NIR) light propagation through tissues to assess the optical properties of tissues for the identification of abnormal tissue. This optical imaging approach is sensitive, cost-effective, and does not involve any ionizing radiation. However, the…
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Special Section Guest Editorial: Computational Approaches for Neuroimaging
This guest editorial provides an introduction to the Special Section on Computational Approaches for Neuroimaging.
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Assessment of Gate Width Size on Lifetime-Based Förster Resonance Energy Transfer Parameter Estimation
Förster Resonance Energy Transfer (FRET) enables the observation of interactions at the nanoscale level through the use of fluorescence optical imaging techniques. In FRET, fluorescence lifetime imaging can be used to quantify the fluorescence lifetime changes of the donor molecule, which are…
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UNMIX-ME: spectral and lifetime fluorescence unmixing via deep learning
Hyperspectral fluorescence lifetime imaging allows for the simultaneous acquisition of spectrally resolved temporal fluorescence emission decays. In turn, the acquired rich multidimensional data set enables simultaneous imaging of multiple fluorescent species for a comprehensive molecular…
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Active wide-field illumination for high-throughput fluorescence lifetime imaging
Wide-field fluorescence lifetime imaging allows for fast imaging of large sample areas at the cost of low sensitivity to weak fluorescence signals. To overcome this challenge, we developed an active wide-field illumination (AWFI) strategy to optimize the impinging spatial intensity for acquiring…
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Quantitative tomographic imaging of intermolecular FRET in small animals
Forster resonance energy transfer (FRET) is a nonradiative transfer of energy between two fluorescent molecules (a donor and an acceptor) in nanometer range proximity. FRET imaging methods have been applied to proteomic studies and drug discovery applications based on intermolecular FRET efficiency…
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Ex Vivo Fluorescence Molecular Tomography of the Spine
We investigated the potential of fluorescence molecular tomography to image ex vivo samples collected from a large animal model, in this case, a dog spine. Wide-field time-gated fluorescence tomography was employed to assess the impact of multiview acquisition, data type, and intrinsic optical…