24 hasil untuk "Johnson, Rob"
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Artikel Jurnal Teks lengkap
The finite state projection approach to analyze dynamics of heterogeneous populations
Population modeling aims to capture and predict the dynamics of cell populations in constant or fluctuating environments. At the elementary level, population growth proceeds through sequential divisions of individual cells. Due to stochastic effects, populations of cells are inherently…
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Artikel Jurnal Teks lengkap
SYSBIONS: nested sampling for systems biology
Motivation: Model selection is a fundamental part of the scientific process in systems biology. Given a set of competing hypotheses, we routinely wish to choose the one that best explains the observed data. In the Bayesian framework, models are compared via Bayes factors (the ratio of evidences)…
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Artikel Jurnal Teks lengkap
Preprints and Scholarly Communication: An Exploratory Qualitative Study of Adoption, Practices, Drivers and Barriers
Background: Since 2013, there has been a dramatic increase in the number of preprint servers. Little is known about the position of researchers, funders, research performing organisations and other stakeholders with respect to this fast-paced landscape. In this article, we explore the perceived…
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Artikel Jurnal Teks lengkap
How does mode of travel affect risks posed to other road users? An analysis of English road fatality data, incorporating gender and road type
BACKGROUND: Most analysis of road injuries examines the risk experienced by people using different modes of transport, for instance, pedestrian fatalities per-head or per-km. A small but growing field analyses the impact that the use of different transport modes has on other road users, for…
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Artikel Jurnal Teks lengkap
deBGR: an efficient and near-exact representation of the weighted de Bruijn graph
MOTIVATION: Almost all de novo short-read genome and transcriptome assemblers start by building a representation of the de Bruijn Graph of the reads they are given as input. Even when other approaches are used for subsequent assembly (e.g. when one is using ‘long read’ technologies like those…
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Artikel Jurnal Teks lengkap
An Efficient, Scalable, and Exact Representation of High-Dimensional Color Information Enabled Using de Bruijn Graph Search
The colored de Bruijn graph (cdbg) and its variants have become an important combinatorial structure used in numerous areas in genomics, such as population-level variation detection in metagenomic samples, large-scale sequence search, and cdbg-based reference sequence indices. As samples or genomes…
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Bab Buku Teks lengkap
Chapter 19 Conclusion
"This book examines the key dimensions of 21st century war, and shows that orthodox thinking about war, particularly what it is and how it is fought, needs to be updated. Accelerating societal, economic, political and technological change affects how we prepare, equip and organise for war, as well…
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Buku Teks lengkap
The Conduct of War in the 21st Century
"This book examines the key dimensions of 21st century war, and shows that orthodox thinking about war, particularly what it is and how it is fought, needs to be updated. Accelerating societal, economic, political and technological change affects how we prepare, equip and organise for war, as well…
Juga tersedia di: OAPEN
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Bab Buku Teks lengkap
Chapter 1 Introduction
"This book examines the key dimensions of 21st century war, and shows that orthodox thinking about war, particularly what it is and how it is fought, needs to be updated. Accelerating societal, economic, political and technological change affects how we prepare, equip and organise for war, as well…
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Artikel Jurnal Teks lengkap
Quantifying Efficiency Gains of Innovative Designs of Two-Arm Vaccine Trials for COVID-19 Using an Epidemic Simulation Model
Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on the power of a trial. We illustrate how the operating characteristics…
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Artikel Jurnal Teks lengkap
Mantis: A Fast, Small, and Exact Large-Scale Sequence-Search Index
Sequence-level searches on large collections of RNA sequencing experiments, such as the NCBI Sequence Read Archive (SRA), would enable one to ask many questions about the expression or variation of a given transcript in a population. Existing approaches, such as the sequence Bloom tree, suffer from…
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Artikel Jurnal Teks lengkap
An incrementally updatable and scalable system for large-scale sequence search using the Bentley–Saxe transformation
MOTIVATION: In the past few years, researchers have proposed numerous indexing schemes for searching large datasets of raw sequencing experiments. Most of these proposed indexes are approximate (i.e. with one-sided errors) in order to save space. Recently, researchers have published exact…
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Bab Buku Teks lengkap
Chapter 1 Introduction
"This book examines the key dimensions of 21st century war, and shows that orthodox thinking about war, particularly what it is and how it is fought, needs to be updated. Accelerating societal, economic, political and technological change affects how we prepare, equip and organise for war, as well…
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Bab Buku Teks lengkap
Chapter 19 Conclusion
"This book examines the key dimensions of 21st century war, and shows that orthodox thinking about war, particularly what it is and how it is fought, needs to be updated. Accelerating societal, economic, political and technological change affects how we prepare, equip and organise for war, as well…
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Artikel Jurnal Teks lengkap
Data needs for integrated economic-epidemiological models of pandemic mitigation policies
The COVID-19 pandemic and the mitigation policies implemented in response to it have resulted in economic losses worldwide. Attempts to understand the relationship between economics and epidemiology has led to a new generation of integrated mathematical models. The data needs for these models…
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Artikel Jurnal Teks lengkap
Bayesian profile regression for clustering analysis involving a longitudinal response and explanatory variables
The identification of sets of co-regulated genes that share a common function is a key question of modern genomics. Bayesian profile regression is a semi-supervised mixture modelling approach that makes use of a response to guide inference toward relevant clusterings. Previous applications of…
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Artikel Jurnal Teks lengkap
Estimating city-level travel patterns using street imagery: A case study of using Google Street View in Britain
BACKGROUND: Street imagery is a promising and growing big data source providing current and historical images in more than 100 countries. Studies have reported using this data to audit road infrastructure and other built environment features. Here we explore a novel application, using Google Street…
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Artikel Jurnal Teks lengkap
The societal value of SARS-CoV-2 booster vaccination in Indonesia
OBJECTIVES: To estimate the expected socio-economic value of booster vaccination in terms of averted deaths and averted closures of businesses and schools using simulation modelling. METHODS: The value of booster vaccination in Indonesia is estimated by comparing simulated societal costs under a…
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Artikel Jurnal Teks lengkap
Promoting healthy populations as a pandemic preparedness strategy: a simulation study from Mexico
BACKGROUND: The underlying health status of populations was a major determinant of the impact of the COVID-19 pandemic, particularly obesity prevalence. Mexico was one of the most severely affected countries during the COVID-19 pandemic and its obesity prevalence is among the highest in the world…