19 hasil untuk "Jun Fu"

Investigation on the influence of airflow on the acoustic performance of a single–Cylinder diesel engine exhaust muffler

Jun Fu; Milan Cheng; Yi Ma dkk.

PLOS One, Vol. 20 No. 6 · 2025 · Inggris · PLOS Scopus

The airflow in the exhaust muffler can affect the sound propagation characteristics. In this work, For a single-cylinder diesel engine, an experimental bench was set up, and the accuracy of the simulation model was verified through the mutual comparison between the experimental data and the…

Study on spray combustion characteristics of liquid ammonia/dimethyl ether dual fuel based on different injection strategies

Jun Fu; Han He; Feibin Yan dkk.

PLOS One, Vol. 20 No. 9 · 2025 · Inggris · PLOS Scopus

Ammonia is a green zero-carbon fuel, yet its low reactivity poses challenges, including difficult ignition and slow combustion rates. Compared to diesel or biodiesel, dimethyl ether (DME) has no C-C bonds, which means it produces almost no soot and has a high cetane number that helps it ignite…

Research on the speed fluctuation control of diesel engine under load changes via an improved sparrow algorithm

Jun Fu; Luchen Lin; Shuo Gu dkk.

PLOS One, Vol. 20 No. 8 · 2025 · Inggris · PLOS Scopus

Given the nonlinear and time-varying characteristics of diesel engine speed control, a conventional proportional integral derivative (PID) controller is inadequate for addressing the lag or overshoot in the system response, and it struggles to adapt to complex dynamic changes under load. This study…

Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis

Chunhua Wan; Jun Fu; Yong Wang dkk.

PLoS ONE, Vol. 7 No. 5 · 2012 · Inggris · PLOS Scopus

We have previously reported that rhomboid domain containing 1 (RHBDD1), a mammalian rhomboid protease highly expressed in the testis, can cleave the Bcl-2 protein Bik. In this study, we identified a multi-pass transmembrane protein, tumor suppressor activated pathway-6 (TSAP6) as a potential…

Diagnostic Value of Liquid-Based Cytology in Urothelial Carcinoma Diagnosis: A Systematic Review and Meta-Analysis

You Luo; Dong-Li She; Hu Xiong dkk.

PLOS ONE, Vol. 10 No. 8 · 2015 · Inggris · PLOS Scopus

Objective: To evaluate the value of liquid-based cytology (LBC) in the diagnosis of urothelial carcinoma. Method: Diagnostic studies were searched for the diagnostic value of LBC in urothelial carcinoma in PubMed, Embase, Cochrane Library, Web of Science, CBM and CNKI. The latest retrieval date was…

Meta-analysis of sonication prosthetic fluid PCR for diagnosing periprosthetic joint infection

Kan Liu; Jun Fu; Baozhan Yu dkk.

PLOS ONE, Vol. 13 No. 4 · 2018 · Inggris · PLOS Scopus

Periprosthetic joint infection (PJI) is a catastrophic complication following total joint arthroplasty. Until now, the diagnosis of PJI is still confronted with difficulties, which is characterized by technical limitations. The question of whether sonication fluid PCR can provide high value in the…

Correction: TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes

Müge Akpınar; Mathias Lesche; Grigorios Fanourgakis dkk.

PLOS Genetics, Vol. 13 No. 9 · 2017 · Inggris · PLOS Scopus

TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes

Müge Akpınar; Mathias Lesche; Grigorios Fanourgakis dkk.

PLOS Genetics, Vol. 13 No. 3 · 2017 · Inggris · PLOS Scopus

Tudor containing protein 6 (TDRD6) is a male germ line-specific protein essential for chromatoid body (ChB) structure, elongated spermatid development and male fertility. Here we show that in meiotic prophase I spermatocytes TDRD6 interacts with the key protein arginine methyl transferase PRMT5…

Acoustic Radiation Force Impulse Imaging for Noninvasive Evaluation of Renal Parenchyma Elasticity: Preliminary Findings

Le-Hang Guo; Hui-Xiong Xu; Hui-Jun Fu dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Objective: To evaluate the diagnostic value of acoustic radiation force impulse (ARFI) to test the elasticity of renal parenchyma by measuring the shear wave velocity (SWV) which might be used to detect chronic kidney disease (CKD). Methods: 327 healthy volunteers and 64 CKD patients were enrolled…

Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis

Xiao-Hong Li; Jie-Jun Fu; Xiao-Juan Shi dkk.

PLOS ONE, Vol. 18 No. 8 · 2023 · Inggris · PLOS Scopus

Background: Studies have shown that the release of endogenous glutamate (Glu) participates in lung injury by activating N-methyl-D-aspartate receptor (NMDAR), but the mechanism is still unclear. This study was to investigate the effects and related mechanisms of Glu on the lipid synthesis of…

Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex

Fong Kuan Wong; Ji-Feng Fei; Felipe Mora-Bermúdez dkk.

PLOS Biology, Vol. 13 No. 8 · 2015 · Inggris · PLOS Scopus

The evolutionary expansion of the neocortex in mammals has been linked to enlargement of the subventricular zone (SVZ) and increased proliferative capacity of basal progenitors (BPs), notably basal radial glia (bRG). The transcription factor Pax6 is known to be highly expressed in primate, but not…

Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior

Brenda Murdoch; Nichole Owen; Michelle Stevense dkk.

PLoS Genetics, Vol. 9 No. 2 · 2013 · Inggris · PLOS Scopus

Based on studies in mice and humans, cohesin loss from chromosomes during the period of protracted meiotic arrest appears to play a major role in chromosome segregation errors during female meiosis. In mice, mutations in meiosis-specific cohesin genes cause meiotic disturbances and infertility…

Enhanced Specificity of TPMT *2 Genotyping Using Unidirectional Wild-Type and Mutant Allele-Specific Scorpion Primers in a Single Tube

Dong Chen; Zhao Yang; Han Xia dkk.

PLoS ONE, Vol. 9 No. 4 · 2014 · Inggris · PLOS Scopus

Genotyping of thiopurine S-methyltransferase (TPMT) is recommended for predicting the adverse drug response of thiopurines. In the current study, a novel version of allele-specific PCR (AS-PCR), termed competitive real-time fluorescent AS-PCR (CRAS-PCR) was developed to analyze the TPMT*2 genotype…

Association between Thiopurine S-methyltransferase Polymorphisms and Thiopurine-Induced Adverse Drug Reactions in Patients with Inflammatory Bowel Disease: A Meta-Analysis

Yue-Ping Liu; Hai-Yan Wu; Xiang Yang dkk.

PLOS ONE, Vol. 10 No. 3 · 2015 · Inggris · PLOS Scopus

Purpose: Thiopurine drugs are well established treatments in the management of inflammatory bowel disease (IBD), but their use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in thiopurine metabolism. Several clinical…

BRAF V600E Mutation and Its Association with Clinicopathological Features of Colorectal Cancer: A Systematic Review and Meta-Analysis

Dong Chen; Jun-Fu Huang; Kai Liu dkk.

PLoS ONE, Vol. 9 No. 3 · 2014 · Inggris · PLOS Scopus

Background: Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. The B-type Raf proto-oncogene (BRAF) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade during CRC. The presence of BRAFV600E mutation can…

Single-Tubed Wild-Type Blocking Quantitative PCR Detection Assay for the Sensitive Detection of Codon 12 and 13 KRAS Mutations

Jun-Fu Huang; Dong-Zhu Zeng; Guang-Jie Duan dkk.

PLOS ONE, Vol. 10 No. 12 · 2015 · Inggris · PLOS Scopus

The high degree of intra-tumor heterogeneity has meant that it is important to develop sensitive and selective assays to detect low-abundance KRAS mutations in metastatic colorectal carcinoma (mCRC) patients. As a major potential source of tumor DNA in the aforementioned genotyping assays, it was…

BRAF Mutations in Patients with Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Dong Chen; Li-Qun Zhang; Jun-Fu Huang dkk.

PLoS ONE, Vol. 9 No. 6 · 2014 · Inggris · PLOS Scopus

Background: BRAF mutations have been well described in non-small cell lung cancer (NSCLC) for several years, but the clinical features of patients harboring BRAF mutations are still not well described. We performed a meta-analysis to identify common clinical features in NSCLC patients carrying BRAF…

PIMT Prevents the Apoptosis of Endothelial Cells in Response to Glycated Low Density Lipoproteins and Protective Effects of Grape Seed Procyanidin B2

Xiao-li Li; Bao-ying Li; Mei Cheng dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Background: The development of diabetic angiopathy is associated with profound vascular endothelial cells (VEC) dysfunction and apoptosis. Glycated low density lipoproteins (gly-LDL) continuously produced in the setting of diabetic patients play an important role in causing VEC dysfunction and…

Proteomic Analysis of Aorta and Protective Effects of Grape Seed Procyanidin B2 in db/db Mice Reveal a Critical Role of Milk Fat Globule Epidermal Growth Factor-8 in Diabetic Arterial Damage

Fei Yu; Bao-ying Li; Xiao-li Li dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Background: Atherosclerosis is one of the major complications of type 2 diabetic patients (T2DM), leading to morbidity and mortality. Grape seed procyanidin B2 (GSPB2) has demonstrated protective effect against atherosclerosis, which is believed to be, at least in part, a result of its…