133 hasil untuk "Junaid Muhammad"
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Preprint Teks lengkap
Dark Matter's influence on Evolution of MBHB in Dwarf Galaxies: A Case Study of Leo I dSph
In this study, we investigate the dynamical evolution of a massive binary black hole (MBHB) in the Leo I dwarf spheroidal galaxy model and examine how dark matter along with stellar matter's gravitational interactions influence its long-term behavior. Using high-resolution direct N-body…
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Artikel Jurnal Teks lengkap
Mini titanium plates and screws for cranial bone flap fixation; an experience from Pakistan
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Artikel Jurnal Teks lengkap
Pneumocystis Pneumonia in Previously Undiagnosed Advanced HIV/AIDS and Importance of HIV Screening
The diagnosis of human immunodeficiency virus (HIV) in its late stages, also known as acquired immunodeficiency syndrome (AIDS), leads to increased morbidity and mortality. This is mostly due to the time given for opportunistic infections to arise, which present with their own complications. In…
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Artikel Jurnal Teks lengkap
Graph convolutional neural networks improved target-specific scoring functions for cGAS and kRAS in virtual screening
In the drug discovery process, traditional structure-based virtual screening methods, such as molecular docking, are often limited by empirical scoring functions. Recent studies have demonstrated that target-specific scoring functions developed using machine learning approaches can enhance the…
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Artikel Jurnal Teks lengkap
Burden of Plasmodium vivax and Plasmodium falciparum Malaria: clinical insights from a prospective study in Jacobabad, Sindh, Pakistan
OBJECTIVE: Jacobabad, located in the northern region of Sindh, is characterized by an extremely hot and humid climate and is classified as a malaria-endemic area, with an annual parasite incidence (API) of 31 per 1000 population in 2024. The present study investigates the incidence of malaria among…
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Artikel Jurnal Teks lengkap
An experience with ventriculoperitoneal shunting at keen’s point for hydrocephalus
OBJECTIVE: This study was conducted to assess outcomes in patients with hydrocephalus who underwent ventriculoperitoneal shunting at Keen’s point. METHODS: This retrospective study was conducted in Combined Military Hospital (CMH) Peshawar. Time frame was four years from January 2011 to January…
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Artikel Jurnal Teks lengkap
Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3
BACKGROUND: The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied with a view to the structure-based development of antiviral inhibitors. Although…
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Artikel Jurnal Teks lengkap
Lipid compositional changes and oxidation status of ultra-high temperature treated Milk
BACKGROUND: Milk fat is one of the complex fat and most sensitive biochemical compounds towards auto-oxidation. To enhance the shelf life, milk is subjected to Ultra-high Temperature (UHT) treatment followed by aseptic packaging. During the storage, several chemical and biochemical changes take…
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Artikel Jurnal Teks lengkap
Thalassemia, extramedullary hematopoiesis, and spinal cord compression: A case report
BACKGROUND: Extramedullary hematopoiesis (EMH) refers to hematopoiesis outside of the medulla of the bone. Chronic anemia states such as thalassemia can cause hematopoietic tissue to expand in certain locations. We report a case of spinal cord compression due to recurrent spinal epidural EMH, which…
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Structural insight into the binding of C60-derivatives with enoyl-pyruvate transferase from Helicobacter pylori
Helicobacter pylori (H. pylori) is a human pathogen associated with acute gastritis and peptic ulcer. The MurA enzyme is an important drug target for the identification of ligands with improved efficacy and acceptable pharmaco-kinetic properties. We developed a homology model of H. Pylori MurA…
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Artikel Jurnal Teks lengkap
Optimal Architecture of Floating-Point Arithmetic for Neural Network Training Processors
The convergence of artificial intelligence (AI) is one of the critical technologies in the recent fourth industrial revolution. The AIoT (Artificial Intelligence Internet of Things) is expected to be a solution that aids rapid and secure data processing. While the success of AIoT demanded low-power…
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Artikel Jurnal Teks lengkap
Single-cell and spatial omics: exploring hypothalamic heterogeneity
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in…
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Artikel Jurnal Teks lengkap
Critical appraisal of progress and challenges in tuberculosis preventive treatment in the Western Pacific Region: a situational analysis of seven high tuberculosis burden countries
We commend Oh et al.’s recent analysis of TB preventive treatment (TPT) in the Western Pacific Region, but note important gaps and ways forward. We first caution that reliance on routine program data may overestimate gains. For example, China’s passive surveillance misses ≈20% of cases [1]…
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Artikel Jurnal Teks lengkap
Comprehensive Single-Cell Transcriptomic Atlas of the Mouse Pons and Medulla
The pons and medulla, key regions of the hindbrain within the brainstem, regulate a wide range of complex behaviors, ranging from motor control to autonomic regulation and reflexes. As the central hub of neural projections and gut-to-brain communication, the cellular diversity that supports these…
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Artikel Jurnal Teks lengkap
Freehand pedicle screw fixation: A safe recipe for dorsal, lumbar and sacral spine
OBJECTIVE: To determine outcome of freehand pedicle screw fixation for dorsal, lumbar and sacral fractures at a tertiary care centre in the developing world. METHODS: A retrospective review was performed of 150 consecutive patients who underwent pedicle screw fixation from January 1, 2012 to 31(st)…
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Analyses of the Binding between Water Soluble C60 Derivatives and Potential Drug Targets through a Molecular Docking Approach
Fullerene C60, a unique sphere-shaped molecule consisting of carbon, has been proved to have inhibitory effects on many diseases. However, the applications of C60 in medicine have been severely hindered by its complete insolubility in water and low solubility in almost all organic solvents. In this…
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Primary pediatric cerebellar gliosarcoma
BACKGROUND: Primary gliosarcomas of the central nervous are rare and very few have been reported in the infratentorial compartment. Here, we describe such a lesion in a 12-year-old male. CASE DESCRIPTION: A 12-year-old male presented with headache, ataxia, and vomiting. When Magnetic resonance…
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Transcranial resection of a juvenile psammomatoid ossifying fibroma of the orbit: A case report with 2-year follow-up
BACKGROUND: Juvenile psammomatoid ossifying fibromas (JPOFs) are benign, locally invasive lesion of the craniofacial skeleton that may undergo rapid growth resulting in damage to cranial and facial structures. They usually occur before the age of 15 years and should be carefully treated as their…
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Artikel Jurnal Teks lengkap
Exploitation of tolerance to drought stress in carrot (Daucus carota L.): an overview
Drought stress is a significant environmental factor that adversely affects the growth and development of carrot (Daucus carota L.), resulting in reduced crop yields and quality. Drought stress induces a range of physiological and biochemical changes in carrots, including reduced germination…