1 results for "Kenneth Gable"

A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Michael A. Kennedy; Kenneth Gable; Karolina Niewola-Staszkowska et al.

PLoS Genetics, Vol. 10 No. 1 · 2014 · English · PLOS Scopus

Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Similar…