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Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

Giulia Calenda; Ines Frank; Géraldine Arrode-Brusés dkk.

PLOS Pathogens, Vol. 15 No. 5 · 2019 · Inggris · PLOS Scopus

VRC01 protects macaques from vaginal SHIV infection after a single high-dose challenge. Infusion of a simianized anti-α4β7 mAb (Rh-α4β7) just prior to, and during repeated vaginal exposures to SIVmac251 partially protected macaques from vaginal SIV infection and rescued CD4+ T cells. To investigate…