67 hasil untuk "Kumar, Awanish"
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COVID-19 gripped the globe with some unnoticed facts and too many questions
Coronavirus disease started in late 2019 is abbreviated as COVID-19. It is caused by severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and is also known as the 2019 novel Coronavirus (nCoV). It is a pandemic of this decade that has shown high morbidity and mortality via causing mild to…
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Proteomics in Host-Protozoan Parasite Interactions and Development of Drug and Vaccine
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l-Asparaginase: a feasible therapeutic molecule for multiple diseases
This note highlights our understanding and thinking about the feasibility of l-asparaginase as therapeutics for multiple diseases. l-asparaginase enzyme (l-asparagine amidohydrolase, EC 3.5.1.1) is prominently known for its chemotherapeutic application. It is primarily used in the treatment of…
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Innovative aspects of protein stability in ionic liquid mixtures
Mixtures of ionic liquids (ILs) have attracted our attention because of their extraordinary performances in extraction technologies and in absorbing large amount of CO(2) gas. It has been observed that when two or more ILs are mixed in different proportions, a new solvent is obtained which is much…
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l-asparaginase: Need for an Expedition from an Enzymatic Molecule to Antimicrobial Drug
Enzymes play a vital role in the biological system as a catalyst for biochemical reactions. They have a wide range of commercial applications in many areas like the pharmaceutical industry, food industry, etc. l-asparaginase is one of the commercial enzymes with prime importance in anticancer…
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Mucosal and transdermal vaccine delivery strategies against COVID-19
The years 2020 and 2021 have witnessed a COVID-19 pandemic caused by the SARS-CoV-2 virus. However, these years have also witnessed certain remarkable scientific achievements. Researchers across the globe have been trying extremely hard and accomplished in bringing vaccines a great variety of…
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A soft-computation hybrid method for search of the antibiotic-resistant gene in Mycobacterium tuberculosis for promising drug target identification and antimycobacterial lead discovery
Tuberculosis (TB) control programs were already piloted before the COVID-19 pandemic commenced and the global TB response was amplified by the pandemic. To combat the global TB epidemic, drug repurposing, novel drug discovery, identification and targeting of the antimicrobial resistance (AMR)…
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Deciphering the bioactive properties of sodium lignosulfonate (LIG) and LIG-induced cell death of human fungal pathogen Candida albicans
The current treatment scenario for antifungal drugs is limited and requires more research. Three structural classes of drugs, namely polyenes, azoles, and echinocandins, are widely used in the treatment of human fungal infections caused by Candida species. Although there is an increase in the…
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Secondary metabolites from endophytic fungi: Production, methods of analysis, and diverse pharmaceutical potential
The synthesis of secondary metabolites is a constantly functioning metabolic pathway in all living systems. Secondary metabolites can be broken down into numerous classes, including alkaloids, coumarins, flavonoids, lignans, saponins, terpenes, quinones, xanthones, and others. However, animals lack…
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Targeted therapy of irritable bowel syndrome with anti-inflammatory cytokines
Irritable bowel syndrome (IBS) is a multifactorial disease of which infection, as well as inflammation, has recently been considered as an important cause. Inflammation works as a potential pathway for the pathogenesis of IBS. In this review, we have discussed the targeted therapy of IBS. We used…
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Promising Antiviral Molecules from Ayurvedic Herbs and Spices against COVID-19
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Deciphering Target Protein Cascade in Salmonella typhi Biofilm using Genomic Data Mining, and Protein-protein Interaction
BACKGROUND: Salmonella typhi biofilm confers a serious public health issue for lengthy periods and the rise in antibiotic resistance and death rate. Biofilm generation has rendered even the most potent antibiotics ineffective in controlling the illness, and the S. typhi outbreak has turned into a…
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Incidentally diagnosed right-sided intrathoracic kidney
Ectopic kidney is a well-known congenital anomaly. Intrathoracic kidney, as a form of renal ectopia, is an extremely rare entity. A 62-year-old man presented to the department of radiodiagnosis for evaluation of urinary problems. On the basis of ultrasonography, he was diagnosed to be having…
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Antioxidant potentials of successive solvent extracts from the unexplored Hedhychium coronarium rhizome
Hedychium coronarium Koen. is considered as an endemic medicinal plant. In the current research antioxidant potential of six different extracts obtained by the successive solvent extraction method from the unexplored H. coronarium rhizome was evaluated. Various in vitro assays were performed to…
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Laparoscopic cholecystectomy in situs inversus: points of technique
Laparoscopic cholecystectomy is one of the most common surgical procedures carried out in the world today. Rarely do patients present with undiagnosed situs inversus with cholecystitis. Symptomatic gallstones in patients with situs inversus pose diagnostic and therapeutic challenges. We had one…
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Primary amyloidoma of chest wall – a rare condition
Organ specific amyloidosis has been shown to be confined to various organs like liver, lung, spleen, urinary bladder and gastro-intestinal tract, but amyloidoma or tumoural amyloidosis of chest wall with no evidence of systemic amyloidosis is an extremely rare presentation and only two cases have…
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Squamous cell carcinoma of kidney co-existing with renal calculi: a rare tumour
Squamous cell carcinoma (SCC) of urinary tract is a very rare tumour known to be associated with chronic renal calculi and infection. This tumour is highly aggressive and often detected at advanced stage with poor outcome. The authors describe a case report of a 62-year-old male patient who was…
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Eucalyptol, sabinene and cinnamaldehyde: potent inhibitors of salmonella target protein l-asparaginase
Salmonella typhimurium is a severe threat to human life. The treatment became more difficult with the emergence of multidrug resistance. In the present in silico study, a novel drug target l-asparaginase was tested against three ligands eucalyptol, sabinene, and cinnamaldehyde, major components of…
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Multiple spontaneous enterocutaneous fistulae on back: a rare presentation of colonic malignancy
We came across a case presenting with complaint of multiple fistulae present on back and lateral part of abdominal wall discharging faecal matter. Investigations revealed a fistulous tract arising from posterior wall of ascending colon. The patient did not respond to conservative management and…
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Chitosan derivatives: A suggestive evaluation for novel inhibitor discovery against wild type and variants of SARS-CoV-2 virus
With increasing global cases and mortality rates due to COVID-19 infection, finding effective therapeutic interventions has become a top priority. Marine resources are not explored much and to be taken into consideration for exploring antiviral potential. Chitosan (carbohydrate polymer) is one such…