12 hasil untuk "LIN Wan"
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Artikel Jurnal Teks lengkap
Dynamic inference of cell developmental complex energy landscape from time series single-cell transcriptomic data
Time series single-cell RNA sequencing (scRNA-seq) data are emerging. However, dynamic inference of an evolving cell population from time series scRNA-seq data is challenging owing to the stochasticity and nonlinearity of the underlying biological processes. This calls for the development of…
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Artikel Jurnal Teks lengkap
Learning collective multicellular dynamics with an interacting mean field neural SDE model
The advent of temporal single-cell RNA sequencing (scRNA-seq) data has enabled in-depth investigation of dynamic processes in heterogeneous multicellular systems. Despite remarkable advancements in computational methods for modeling cellular dynamics, integrating cell-cell interactions (CCIs) into…
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Seismic prediction of shale oil lithofacies associations based on sedimentary facies patterns: A case study of the shahejie formation in the Huanghekou Sag
The lithofacies play a pivotal role in studying development patterns, reservoir characteristics, and sweet spot predictions of shale oil. Lithofacies classification typically relies on core observations and conventional well logging analyses, whereas seismic attribute extraction is often employed…
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Artikel Jurnal Teks lengkap
Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function
It is generally accepted that ATP regulates mitochondrial function through the AMPK signaling pathway. However, the AMPK-independent pathway remains largely unknown. In this study, we investigated ATP surplus in the negative regulation of mitochondrial function with a focus on pyruvate…
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Artikel Jurnal Teks lengkap
A remark on copy number variation detection methods
Copy number variations (CNVs) are gain and loss of DNA sequence of a genome. High throughput platforms such as microarrays and next generation sequencing technologies (NGS) have been applied for genome wide copy number losses. Although progress has been made in both approaches, the accuracy and…
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Artikel Jurnal Teks lengkap
Bombesin Analogue-Mediated Delivery Preferentially Enhances the Cytotoxicity of a Mitochondria-Disrupting Peptide in Tumor Cells
Tumor-homing peptides that recognize specific markers on tumor cells have shown potential as drug carriers for targeted cancer therapy. Bombesin receptors are frequently overexpressed or ectopically expressed in a wide range of human tumors. Bombesin and its analogues have been widely used as drug…
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Cost-effectiveness of mini-laparotomy in patients with colorectal cancers: A propensity scoring matching approach
Objective: Surgical technique process innovations are expected to generally incur no additional cost but gain better quality. Whether a mini-laparotomy surgery (MLS) in the treatment of colorectal cancer (CRC) is more cost effective than conventional open surgery had not been well examined. The…
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Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia/reperfusion Injury via PTEN/Akt Pathway
Background: Ischemic postconditioning (IPost) protects the reperfused heart from infarction which has drawn much attention recently. However, studies to date have rarely investigated the role of microRNAs (miRNAs) in IPost. The aims of this study were to investigate whether miR-21 is involved in…
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In Vivo Monitoring of Angiogenesis Inhibition via Down-Regulation of Mir-21 in a VEGFR2-Luc Murine Breast Cancer Model Using Bioluminescent Imaging
MicroRNA-21 (miR-21) is overexpressed in a wide range of cancers and involved in tumor proliferation and metastasis. However, the potential function of miR-21 in regulating tumor angiogenesis has been little disclosed. In this study, we treated the cultured 4T1 murine breast cancer cells and human…
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Arsenic Trioxide and Resveratrol Show Synergistic Anti-Leukemia Activity and Neutralized Cardiotoxicity
Cardiotoxicity is an aggravating side effect of many clinical antineoplastic agents such as arsenic trioxide (As2O3), which is the first-line treatment for acute promyelocytic leukemia (APL). Clinically, drug combination strategies are widely applied for complex disease management. Here, an…
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Artikel Jurnal Teks lengkap
EPO Promotes Bone Repair through Enhanced Cartilaginous Callus Formation and Angiogenesis
Erythropoietin (EPO)/erythropoietin receptor (EPOR) signaling is involved in the development and regeneration of several non-hematopoietic tissues including the skeleton. EPO is identified as a downstream target of the hypoxia inducible factor-α (HIF-α) pathway. It is shown that EPO exerts a…
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Artikel Jurnal Teks lengkap
MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing
Nucleoside reverse transcriptase translocation inhibitors (NRTTIs) are potent antiretroviral agents that block HIV replication. A comprehensive lead optimization campaign was undertaken to develop a novel long-acting NRTTI with the potential for extended-duration dosing for HIV prophylaxis. Broad…