8 results for "Larkin, Jacob C."
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The influence of ligand-activated LXR on primary human trophoblasts
INTRODUCTION: The Liver X Receptors (LXRs) are critical transcriptional regulators of cellular metabolism that promote cholesterol efflux and lipogenesis in response to excess intracellular cholesterol. In contrast, the Sterol Response Element Binding Protein-2 (SREBP2) promotes the synthesis and…
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Machine Learning for Fetal Growth Prediction
Birthweight is often used as a proxy for fetal weight. Problems with this practice have recently been brought to light. We explore whether data available at birth can be used to predict estimated fetal weight using linear and quantile regression, random forests, Bayesian additive regression trees…
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The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of…
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Clinical Outcomes Associated With a Remote Postpartum Hypertension Monitoring Program
OBJECTIVE: To evaluate differences in healthcare utilization and guideline adherence for postpartum individuals with a hypertensive disorder of pregnancy (HDP) engaged in a remote monitoring program compared with usual care. METHODS: This was a retrospective cohort study of postpartum individuals…
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Perinatal Outcomes and Unconventional Natural Gas Operations in Southwest Pennsylvania
Unconventional gas drilling (UGD) has enabled extraordinarily rapid growth in the extraction of natural gas. Despite frequently expressed public concern, human health studies have not kept pace. We investigated the association of proximity to UGD in the Marcellus Shale formation and perinatal…
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The expression level of C19MC miRNAs in early pregnancy and in response to viral infection
INTRODUCTION: We have previously shown that miRNAs produced from the Chromosome 19 MiRNA Cluster (C19MC), which are expressed almost exclusively in primate trophoblasts and are released into the maternal circulation, reduce viral replication in non-placental cells and can modulate migratory…
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Customized versus population growth standards for morbidity and mortality risk stratification using ultrasonographic fetal growth assessment at 22-29 weeks’ gestation
OBJECTIVE: To compare the performance of ultrasonographic customized and population fetal growth standards for prediction adverse perinatal outcomes. STUDY DESIGN: This was a secondary analysis of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be, in which l data were collected at…
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Objectively assessed sleep-disordered breathing during pregnancy and infant birthweight
BACKGROUND: Sleep-disordered breathing (SDB) in pregnancy is associated with adverse maternal outcomes. The relationship between SDB and infant birthweight is unclear. This study’s primary aim is to determine if objectively measured SDB in pregnancy is associated with infant birthweight. METHODS…