45 hasil untuk "Li, Gui-Rong"
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Artikel Jurnal Teks lengkap
Functional ion channels in stem cells
Bioelectrical signals generated by ion channels play crucial roles in excitation genesis and impulse conduction in excitable cells as well as in cell proliferation, migration and apoptosis in proliferative cells. Recent studies have demonstrated that multiple ion channels are heterogeneously…
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Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells
Bradykinin is a well-known endogenous vasoactive peptide. The present study investigated the bradykinin receptor expression in human cardiac c-Kit(+) progenitor cells and the potential role of bradykinin in regulating cell cycling progression and mobility. It was found that mRNA and protein of…
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TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells
The earlier study showed that lysophosphatidylcholine (lysoPC) induced apoptosis in human coronary artery smooth muscle cells (SMCs); however, the related molecular mechanisms are not fully understood. The present study investigated how lysoPC induces apoptosis in cultured human coronary artery…
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Knowledge and Psychological Stress Related to COVID-19 Among Nursing Staff in a Hospital in China: Cross-Sectional Survey Study
BACKGROUND: Since December 2019, coronavirus disease (COVID-19) has been rapidly spreading worldwide. Nurses play a key role in fighting this disease and are at risk of COVID-19 infection. Therefore, there is an urgent need to assess the mental health condition of nurses and establish appropriate…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Regulation of cell proliferation by intermediate-conductance Ca(2+)-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells
Bone marrow mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine; however, their cellular physiology is not fully understood. The present study aimed at exploring the potential roles of the two dominant functional ion channels, intermediate-conductance…
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Artikel Jurnal Teks lengkap
Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals
The strategy of decreasing atherosclerotic cardiovascular disorder is imperative for reducing premature death and improving quality of life in patients with diabetes mellitus. The aim of this study was to investigate whether the natural flavone acacetin could protect against endothelial injury…
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Artikel Jurnal Teks lengkap
A study on the preparation and application of a core–shell surface imprinted uranyl magnetic chelating adsorbent
A core–shell surface imprinted uranyl magnetic chelating adsorbent (UMCA) was synthesized by combining the sol–gel process with the surface molecular imprinting technique (SMIT). A specific salophen and uranyl–salophen were designed and synthesized. Then, the synthesized uranyl–salophen complex was…
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Cholesterol Down-Regulates BK Channels Stably Expressed in HEK 293 Cells
Cholesterol is one of the major lipid components of the plasma membrane in mammalian cells and is involved in the regulation of a number of ion channels. The present study investigates how large conductance Ca(2+)-activated K(+) (BK) channels are regulated by membrane cholesterol in BK-HEK 293…
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Effects of diltiazem and nifedipine on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes
1. It is unknown whether the widely used L-type Ca(2+) channel antagonists diltiazem and nifedipine would block the repolarization K(+) currents, transient outward current (I(to1)) and ultra-rapid delayed rectifier K(+) current (I(Kur)), in human atrium. The present study was to determine the…
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Functional TRPV2 and TRPV4 channels in human cardiac c‐kit(+) progenitor cells
The cellular physiology and biology of human cardiac c‐kit(+) progenitor cells has not been extensively characterized and remains an area of active research. This study investigates the functional expression of transient receptor potential vanilloid (TRPV) and possible roles for this ion channel in…
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An improved embryo-rescue protocol for hybrid progeny from seedless Vitis vinifera grapes × wild Chinese Vitis species
A highly efficient technique of embryo rescue is critical when using stenospermocarpic Vitis vinifera cultivars (female parents) to breed novel, disease-resistant, seedless grape cultivars by hybridizing with wild Chinese Vitis species (male parents) having many disease-resistance alleles. The…
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The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells
BACKGROUND AND PURPOSE: N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide (W-7) is a well-known calmodulin inhibitor used to study calmodulin regulation of intracellular Ca(2+) signalling-related process. Here, we have determined whether W-7 would inhibit human ether [Image: see text]gene (hERG…
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Artikel Jurnal Teks lengkap
Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents
1. The antifungal antibiotic clotrimazole (CLT) shows therapeutic effects on cancer, sickle cell disease, malaria, etc. by inhibiting membrane intermediate-conductance Ca(2+)-activated K(+) channels (IK(Ca)). However, it is unclear whether this drug would affect human cardiac K(+) currents. The…
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Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR)2.3 channel, stably expressed in HEK 293 cells
BACKGROUND AND PURPOSE: The detailed molecular modulation of inward rectifier potassium channels (including the K(IR)2.3 channel) is not fully understood. The present study was designed to determine whether human K(IR)2.3 (K(IR)2.3) channels were regulated by protein tyrosine kinases (PTKs)…
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Uncovered stent insertion for isolated superior mesenteric artery dissection
The aim of this study is to describe our clinical outcomes in isolated superior mesenteric artery dissection (SMAD) patients that underwent uncovered stent insertion. Between January 2016 and August 2019, consecutive isolated SMAD patients at our center were treated via uncovered stent insertion…
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Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy
Cardiac senescence is associated with cardiomyopathy which is a degenerative disease in the aging process of the elderly. The present study investigates using multiple experimental approaches whether the natural flavone acacetin could attenuate myocardial senescence in C57/BL6 mice and H9C2 rat…
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Artikel Jurnal Teks lengkap
Adenosine-5′-triphosphate up-regulates proliferation of human cardiac fibroblasts
BACKGROUND AND PURPOSE: ATP is a potent signalling molecule that regulates biological activities including increasing or decreasing proliferation in different types of cells. The aim of the present study was to investigate how ATP regulates the proliferation of human cardiac fibroblasts…
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Artikel Jurnal Teks lengkap
Genistein and tyrphostin AG556 decrease ultra‐rapidly activating delayed rectifier K(+) current of human atria by inhibiting EGF receptor tyrosine kinase
BACKGROUND AND PURPOSE: The ultra‐rapidly activating delayed rectifier K(+) current I (Kur) (encoded by K(v)1.5 or KCNA5) plays an important role in human atrial repolarization. The present study investigates the regulation of this current by protein tyrosine kinases (PTKs). EXPERIMENTAL APPROACH…