88 hasil untuk "Li, Tianshu"
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A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes
Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. Herein, we use maleimide to modify the surface of liposomes in order to obtain an advanced drug delivery system. Employing a small amount (0.3 mol%) of…
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Enhanced cellular uptake of maleimide-modified liposomes via thiol-mediated transport
With a small amount of maleimide modification on the liposome surface, enhanced cellular uptake of liposomes and drug-delivery efficiency can be obtained both in vitro and in vivo. Herein, we describe the mechanisms underlying this enhanced cellular uptake. Suppression of the cellular uptake of…
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A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets
The application of hidden Markov models (HMMs) to neural data has uncovered hidden states and signatures of neural dynamics that are relevant for sensory and cognitive processes. However, training an HMM on cortical data requires a careful handling of model selection, since models with more…
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Enhanced heterogeneous ice nucleation by special surface geometry
The freezing of water typically proceeds through impurity-mediated heterogeneous nucleation. Although non-planar geometry generically exists on the surfaces of ice nucleation centres, its role in nucleation remains poorly understood. Here we show that an atomically sharp, concave wedge can further…
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Gender differences in the relationship between cardiometabolic index and all-cause and specific mortality in the United States adults: a national study
BACKGROUND: The cardiometabolic index (CMI) is a new comprehensive measure that reflects visceral obesity and metabolic function. This study aimed to examine associations between CMI and adult mortality from all causes and specific causes, as well as gender differences, using the National Health…
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Data-Driven Crystal Structure Prediction for Ternary Metal Chalcogenides
The efficient design and discovery of stable inorganic crystal structures is central to materials innovation. Here, we compare data-driven approaches for accelerated crystal structure prediction: substitution into known prototype structures, generative artificial intelligence (genAI) using…
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The Significance of Landscape Perception Research for Practical Decision-Making in the Context of Big Data: A Case Study of the Xiaoxishan Trail in Beijing
Within the context of public health initiatives, trails serve as critical infrastructure in public service systems, requiring planning that integrates multidimensional landscape information and user preferences. However, conventional methodologies struggle to comprehensively capture…
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How Do Specific Social Supports (Family, Friend, and Specialist) Reduce Stress in Patients With Substance Use Disorders: A Multiple Mediation Analysis
Perceived social support has been found to reduce the stress of individuals who suffer from substance use disorders. However, the mediating effects of resilience and affect balance in the relationships between specific social supports (family, friend, and significant others) and perceived stress…
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Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis
As important modulators in various physiological processes, circular RNAs (circRNAs) have been increasingly demonstrated in tumors, including papillary thyroid cancer (PTC). Hsa_circRNA_102002 (circ_102002) is a circRNA derived from alternative splicing of ubiquitin-specific peptidase 22 (USP22)…
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Relationship between plasma atherogenic index and thyroid function: evidence from NHANES 2007–2012
Thyroid function levels have been associated with a variety of metabolic disorders and correlate with blood lipid levels in vivo. However, no studies have been conducted on the correlation between plasma atherogenic index (AIP) and thyroid function levels. The objective of this study was to explore…
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PlantMP: a database for moonlighting plant proteins
Moonlighting proteins are single polypeptide chains capable of executing two or more distinct biochemical and/or biological functions. Here, we describe the development of PlantMP, which is a manually curated online-based database of plant proteins that are known to `moonlight’. The database…
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A Refractive Index Sensor Based on H-Shaped Photonic Crystal Fibers Coated with Ag-Graphene Layers
An Ag-graphene layers-coated H-shaped photonic crystal fiber (PCF) surface plasmon resonance (SPR) sensor with a U-shaped grooves open structure for refractive index (RI) sensing is proposed and numerically simulated by the finite element method (FEM). The designed sensor could solve the problems…
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Characteristic Analysis and Structural Design of Hollow-Core Photonic Crystal Fibers with Band Gap Cladding Structures
Due to their flexible structure and excellent optical characteristics hollow-core photonic crystal fibers (HC-PCFs) are used in many fields, such as active optical devices, communications, and optical fiber sensing. In this paper, to analyze the characteristics of HC-PCFs, we carried out finite…
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MiR-145 functions as a tumor suppressor in Papillary Thyroid Cancer by inhibiting RAB5C
Papillary thyroid carcinoma (PTC) accounts for the largest proportion of thyroid cancers; and its morbidity rate has dramatically increased in recent decades. However, the pathogenesis mechanisms of PTC are still not clear. This study aimed to reveal that miR-145 acts as an antitumor miRNA in the…
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The association between visceral adiposity index and risk of type 2 diabetes mellitus
Relationships between the visceral adiposity index (VAI) and type 2 diabetes mellitus (T2DM) have been underexplored. The purpose of this study is to explore association between VAI and T2DM in adults in the US. Based on the National Health and Nutrition Examination Survey 2007–2018, 11,214…
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Development of the observation of membrane fusion with label-free liposomes by calcium imaging
Liposomes are artificial vesicles composed of lipid bilayers that have enabled drugs to be encapsulated and delivered to tumor tissue. Membrane-fusogenic liposomes fuse with the plasma membranes of cells to deliver encapsulated drugs directly to the cytosol, which makes it a promising method for…
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DCATNet: polyp segmentation with deformable convolution and contextual-aware attention network
Polyp segmentation is crucial in computer-aided diagnosis but remains challenging due to the complexity of medical images and anatomical variations. Current state-of-the-art methods struggle with accurate polyp segmentation due to the variability in size, shape, and texture. These factors make…
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Formation and Diffusion of Metal Impurities in Perovskite Solar Cell Material CH(3)NH(3)PbI(3): Implications on Solar Cell Degradation and Choice of Electrode
Solar cells based on methylammonium lead triiodide (MAPbI(3)) have shown remarkable progress in recent years and have demonstrated efficiencies greater than 20%. However, the long‐term stability of MAPbI(3)‐based solar cells has yet to be achieved. Besides the well‐known chemical and thermal…
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Metastability and Ostwald step rule in the crystallisation of diamond and graphite from molten carbon
Experimental challenges in determining the phase diagram of carbon at temperatures and pressures near the graphite-diamond-liquid triple point are often related to the persistence of metastable crystalline or glassy phases, superheated crystals, or supercooled liquids. A deeper understanding of the…