10 results for "Li-San Wang"

The Cobweb of Life Revealed by Genome-Scale Estimates of Horizontal Gene Transfer

Fan Ge; Li-San Wang; Junhyong Kim

PLoS Biology, Vol. 3 No. 10 · 2005 · English · PLOS Scopus

With the availability of increasing amounts of genomic sequences, it is becoming clear that genomes experience horizontal transfer and incorporation of genetic information. However, to what extent such horizontal gene transfer (HGT) affects the core genealogical history of organisms remains…

Age-Correlated Gene Expression in Normal and Neurodegenerative Human Brain Tissues

Kajia Cao; Alice S. Chen-Plotkin; Joshua B. Plotkin et al.

PLoS ONE, Vol. 5 No. 9 · 2010 · English · PLOS Scopus

Background: Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors. Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by…

Analysis of Nonlinear Gene Expression Progression Reveals Extensive Pathway and Age-Specific Transitions in Aging Human Brains

Kajia Cao; Paul Ryvkin; Yih-Chii Hwang et al.

PLoS ONE, Vol. 8 No. 10 · 2013 · English · PLOS Scopus

Several recent gene expression studies identified hundreds of genes that are correlated with age in brain and other tissues in human. However, these studies used linear models of age correlation, which are not well equipped to model abrupt changes associated with particular ages. We developed a…

Genomic Landscape of a Three-Generation Pedigree Segregating Affective Disorder

Shuzhang Yang; Kai Wang; Brittany Gregory et al.

PLoS ONE, Vol. 4 No. 2 · 2009 · English · PLOS Scopus

Bipolar disorder (BPD) is a common psychiatric illness with a complex mode of inheritance. Besides traditional linkage and association studies, which require large sample sizes, analysis of common and rare chromosomal copy number variants (CNVs) in extended families may provide novel insights into…

Genome-Wide Double-Stranded RNA Sequencing Reveals the Functional Significance of Base-Paired RNAs in Arabidopsis

Qi Zheng; Paul Ryvkin; Fan Li et al.

PLoS Genetics, Vol. 6 No. 9 · 2010 · English · PLOS Scopus

The functional structure of all biologically active molecules is dependent on intra- and inter-molecular interactions. This is especially evident for RNA molecules whose functionality, maturation, and regulation require formation of correct secondary structure through encoded base-pairing…

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

Alexandre Amlie-Wolf; Paul Ryvkin; Rui Tong et al.

PLOS ONE, Vol. 10 No. 10 · 2015 · English · PLOS Scopus

TAR DNA-binding protein 43 (TDP-43) is normally a nuclear RNA-binding protein that exhibits a range of functions including regulation of alternative splicing, RNA trafficking, and RNA stability. However, in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43…

Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

Akinori Miyashita; Asako Koike; Gyungah Jun et al.

PLoS ONE, Vol. 8 No. 7 · 2013 · English · PLOS Scopus

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

Akinori Miyashita; Asako Koike; Gyungah Jun et al.

PLoS ONE, Vol. 8 No. 4 · 2013 · English · PLOS Scopus

To discover susceptibility genes of late-onset Alzheimer’s disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic…

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

Johanna Jakobsdottir; Sven J. van der Lee; Joshua C. Bis et al.

PLOS Genetics, Vol. 12 No. 10 · 2016 · English · PLOS Scopus

We performed an exome-wide association analysis in 1393 late-onset Alzheimer’s disease (LOAD) cases and 8141 controls from the CHARGE consortium. We found that a rare variant (P155L) in TM2D3 was enriched in Icelanders (~0.5% versus

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Valentina Escott-Price; Céline Bellenguez; Li-San Wang et al.

PLoS ONE, Vol. 9 No. 6 · 2014 · English · PLOS Scopus

Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach…