1 hasil untuk "Lihao Lin"

Mechanistically informed machine learning links non-canonical TCA cycle activity to Warburg metabolism and hallmarks of malignancy

Lihao Lin; Francesco Lapi; Bruno Giovanni Galuzzi dkk.

PLOS Computational Biology, Vol. 21 No. 12 · 2025 · Inggris · PLOS Scopus

Cancer cells undergo extensive metabolic rewiring to support growth, survival, and phenotypic plasticity. A non-canonical variant of the tricarboxylic acid (TCA) cycle, characterized by mitochondrial-to-cytosolic citrate export, has emerged as critical for embryonic stem cell differentiation…