103 hasil untuk "Lim, Kenneth"
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Artikel Jurnal Teks lengkap
Is there a relationship between fetal sex and placental pathological characteristics in twin gestations?
BACKGROUND: Placenta plays a central role in mediating growth and development of fetuses. Sex-specific placentas may complicate this role. METHODS: The study aimed at investigating the association between fetal sex and placental pathological findings in twin gestations using generalized estimating…
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Adverse maternal outcomes and birth weight discordance in twin gestation: British Columbia, Canadian data
OBJECTIVE: The aim of this study was to determine whether twin pregnancies with birth weight discordance were associated with higher rates of maternal morbidities. STUDY DESIGN: A large retrospective population-based cohort study of twins born in British Columbia, Canada, from 2000 to 2010 was…
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The role of non-enzymatic post translational protein modifications in uremic vascular calcification
Considerable technological advances have enabled the identification and linkage of non-enzymatic post-translationally modified proteins to the pathogenesis of cardiovascular disease (CVD) in patients with kidney failure. Through processes such as the non-enzymatic carbamylation reaction as well as…
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Vitamin D Toxicity
Fortification of food products with vitamin D was central to the eradication of rickets in the early parts of the 20th century in the United States. In the subsequent almost 100 years since, accumulating evidence has linked vitamin D deficiency to a variety of outcomes, and this has paralleled…
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Management of Suspected Stage IVA Endometrial Cancer With Rectosigmoid Involvement Using Neoadjuvant Chemotherapy and Interval Surgery
Stage IVA endometrial cancer with rectosigmoid involvement is rare and presents challenges for primary surgical management due to the risk of major multivisceral resection and associated morbidity. We report the case of a 55-year-old woman who presented with prolonged postmenopausal bleeding…
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Vitamin D and Calcimimetics in Cardiovascular Disease
Cardiovascular disease has earned its place as one of the leading non-communicable diseases that has become a modern-day global epidemic. The rising incidence and prevalence of Chronic Kidney Disease (CKD) has added to this enormous burden, given that CKD is now recognized as an established risk…
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Aging and wisdom: age-related changes in economic and social decision making
World life expectancy is increasing and many populations will begin to age rapidly. The impeding prevalence of a greater number of older people living longer lives will have significant social and economic implications. It is important to understand how older people make economic and social…
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Challenges in management of nephrolithiasis in a patient with class III obesity (BMI 97)
Patients with severe obesity have an increased risk of renal and ureteral calculi formation, and therefore, increased risk of associated complications. Despite the expanding number of people with obesity, there remains a dearth of scientific literature and training in navigating the associated…
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Management of pregnancy in a patient with previous surgical repair of classic bladder exstrophy
INTRODUCTION & IMPORTANCE: Bladder exstrophy epispadias complex (BEEC) is a rare congenital midline malformation defect which requires complex, staged reconstruction of the bony pelvis and the genitourinary tract. PRESENTATION OF CASE: A 26-year-old G3SA2 with previously reconstructed bladder…
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Treating anaplastic lymphoma kinase (ALK) fusion-driven metastatic non-small cell lung cancer (NSCLC) with alectinib through pregnancy
Management of cancer during pregnancy requires careful consideration of risks and benefits from maternal and fetal perspectives. For advanced lung adenocarcinomas, with no targetable driver mutations, there is evidence-based guidance on the use of carboplatin–paclitaxel chemotherapy after first…
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Vitamin D and Atherosclerotic Cardiovascular Disease
CONTEXT: A large body of experimental and observational data has implicated vitamin D deficiency in the development of cardiovascular disease. However, evidence to support routine vitamin D supplementation to prevent or treat cardiovascular disease is lacking. EVIDENCE ACQUISITION: A comprehensive…
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Robot-assisted right ureteral polypectomy: A case report
Ureteral polyps are a rare cause of ureteral obstruction in the adult and pediatric populations. Fibroepitheial polyps (FEP) are the most common type of ureteral polyps. This clinical entity is very rare, warranting periodic clinical review by practitioners, and new advancements in laparoscopy…
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PSUN32 Critical Illness-Related Corticosteroid Insufficiency (CIRCI) Among Patients with COVID-19 at a Tertiary Hospital: Clinical Characteristics and Outcomes
INTRODUCTION: A significant number of patients afflicted with COVID-19, a viral illness caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), present with refractory shock, hemodynamic instability, acute respiratory distress syndrome and other severe manifestations of…
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The Development of a Protocol for Critical Illness-Related Corticosteroid Insufficiency (CIRCI) at a Tertiary Hospital
OBJECTIVES: The diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) remains a challenge. This initiative aimed to develop a protocol for the diagnosis and management of CIRCI which will facilitate informed decision-making among clinicians through…
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Critical Illness-Related Corticosteroid Insufficiency (CIRCI) Among Patients with COVID-19 at a Tertiary Hospital: Clinical Characteristics and Outcomes*
OBJECTIVES: Among critically ill patients, there is usually impairment of the hypothalamic-pituitary-adrenal axis, leading to a condition known as critical illness-related corticosteroid insufficiency (CIRCI). This investigation aims to determine the incidence of and characterize CIRCI among…
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Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling factors, with causal roles in…
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Klotho: A Major Shareholder in Vascular Aging Enterprises
Accelerated vascular aging is a condition that occurs as a complication of several highly prevalent inflammatory conditions such as chronic kidney disease, cancer, HIV infection and diabetes. Age-associated vascular alterations underlie a continuum of expression toward clinically overt…
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Enrollee, Plan, and State Characteristics Associated With Experience of Care Among Adults in Medicaid Managed Care
OBJECTIVE: To examine five enrollee‐reported experience of care metrics and assess enrollee, plan, and state characteristics associated with higher care ratings. STUDY SETTING AND DESIGN: We conducted a repeated cross‐sectional study using multivariable linear probability models and predictors that…