17 hasil untuk "Lin Du"
Menampilkan 1–17 · 0,84 detik · RSS
-
Artikel Jurnal Teks lengkap
CMCL-DDI: Pharmacophore-aware cross-view contrastive learning for drug-drug interaction prediction
Accurate prediction of potential drug-drug interactions (DDIs) is vital for ensuring medication safety and efficacy. Existing graph-based methods typically focus on molecular structures but often overlook the complementary semantic information embedded in SMILES (Simplified Molecular Input Line…
-
Artikel Jurnal Teks lengkap
Mdb1, a Fission Yeast Homolog of Human MDC1, Modulates DNA Damage Response and Mitotic Spindle Function
During eukaryotic DNA damage response (DDR), one of the earliest events is the phosphorylation of the C-terminal SQ motif of histone H2AX (H2A in yeasts). In human cells, phosphorylated H2AX (γH2AX) is recognized by MDC1, which serves as a binding platform for the accumulation of a myriad of DDR…
-
Artikel Jurnal Teks lengkap
Potential of vegetation indices combined with laser-induced fluorescence parameters for monitoring leaf nitrogen content in paddy rice
Nitrogen (N) is important for the growth of crops. Leaf nitrogen content (LNC) serves as a crucial indicator of the growth status of crops and can help determine the dose of N fertilizer. Laser-induced fluorescence (LIF) technology and the reflectance spectra of crops are widely used to detect the…
-
Artikel Jurnal Teks lengkap
Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks
Hexavalent chromium [Cr(VI)] damages DNA and causes cancer, but it is unclear which DNA damage responses (DDRs) most critically protect cells from chromate toxicity. Here, genome-wide quantitative functional profiling, DDR measurements and genetic interaction assays in Schizosaccharomyces pombe…
-
Artikel Jurnal Teks lengkap
Machine learning in predicting outcomes for stroke patients following rehabilitation treatment: A systematic review
Objective: This review aimed to summarize the use of machine learning for predicting the potential benefits of stroke rehabilitation treatments, to evaluate the risk of bias of predictive models, and to provide recommendations for future models. Materials and methods: This systematic review was…
-
Artikel Jurnal Teks lengkap
Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish
This in vivo time-lapse imaging study in zebrafish reveals how changes to brain blood flow drive vessel pruning via endothelial cell migration, and how pruning leads to the simplification of the brain vasculature during development. Author Summary: Although the brain comprises only 2% of body…
-
Artikel Jurnal Teks lengkap
Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
In response to DNA damage, the eukaryotic genome surveillance system activates a checkpoint kinase cascade. In the fission yeast Schizosaccharomyces pombe, checkpoint protein Crb2 is essential for DNA damage-induced activation of downstream effector kinase Chk1. The mechanism by which Crb2 mediates…
-
Artikel Jurnal Teks lengkap
Adjunctive Manual Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials
Objective: The aim of this study was to synthesize evidence by examining the effects of manual thrombus aspiration on clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). Methods and Results: A total of 26 randomized controlled trials (RCTs), enrolling 11,780…
-
Artikel Jurnal Teks lengkap
CRL4 Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation
Structure-specific endonucleases (SSEs) play key roles in DNA replication, recombination, and repair. SSEs must be tightly regulated to ensure genome stability but their regulatory mechanisms remain incompletely understood. Here, we show that in the fission yeast Schizosaccharomyces pombe, the…
-
Artikel Jurnal Teks lengkap
Dietary Pattern and Its Association with the Prevalence of Obesity and Related Cardiometabolic Risk Factors among Chinese Children
Background: The association of dietary pattern with chronic diseases has been investigated widely in western countries. However, information is quite limited among children in China. Our study is aimed to identify the dietary patterns of Chinese children and examine their association with obesity…
-
Artikel Jurnal Teks lengkap
Global Analysis of Fission Yeast Mating Genes Reveals New Autophagy Factors
Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important roles in animal development and human diseases. Molecular understanding of autophagy has mainly come from the budding yeast Saccharomyces cerevisiae, and it remains unclear to what extent the mechanisms…
-
Artikel Jurnal Teks lengkap
Curvilinear Effects of Invasive Plants on Plant Diversity: Plant Community Invaded by Sphagneticola trilobata
The effects of invasive plants on the species diversity of plant communities are controversial, showing either a positive or negative linear relationship. Based on community data collected from forty 5 m×5 m plots invaded by Sphagneticola trilobata in eight cities across Hainan Island, China, we…
-
Artikel Jurnal Teks lengkap
The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast
Selective macroautophagy of the endoplasmic reticulum (ER) and the nucleus, known as ER-phagy and nucleophagy, respectively, are processes whose mechanisms remain inadequately understood. Through an imaging-based screen, we find that in the fission yeast Schizosaccharomyces pombe, Yep1 (also known…
-
Artikel Jurnal Teks lengkap
Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats
The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels of replication threats remains elusive. Here, we have identified that a conserved GSK-3 kinase Mck1…
-
Artikel Jurnal Teks lengkap
The Costs and Cost-Effectiveness of a School-Based Comprehensive Intervention Study on Childhood Obesity in China
Background: The dramatic rise of overweight and obesity among Chinese children has greatly affected the social economic development. However, no information on the cost-effectiveness of interventions in China is available. The objective of this study is to evaluate the cost and the…
-
Artikel Jurnal Teks lengkap
Fission Yeast Pxd1 Promotes Proper DNA Repair by Activating Rad16 XPF and Inhibiting Dna2
: During DNA double-strand break repair, two structure-specific DNA nucleases are controlled by the same regulator Pxd1, but in opposite manners. Structure-specific nucleases play crucial roles in many DNA repair pathways. They must be precisely controlled to ensure optimal repair outcomes…
-
Artikel Jurnal Teks lengkap
Characteristics of Differently Located Colorectal Cancers Support Proximal and Distal Classification: A Population-Based Study of 57,847 Patients
Background: It has been suggested that colorectal cancer be regarded as several subgroups defined according to tumor location rather than as a single entity. The current study aimed to identify the most useful method for grouping colorectal cancer by tumor location according to both baseline and…