30 hasil untuk "Lin Guo"
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Digital transformation, green innovation and the Solow productivity paradox
To provide evidence at the micro level for cracking the Solow productivity paradox, this paper deeply studies the impact of enterprise digital transformation on green innovation. In terms of theoretical research, three potential mechanisms are excavated for the first time; considering empirical…
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Revolutionizing pharmaceutical innovation: Unveiling the impact of endogenous knowledge spillover in China
Modern medical technology innovation is a critical safeguard for human health, while a significant number of developing nations are confronted with the challenge of biopharmaceutical technological advancement. To investigate the possible routes of technological advancement, we investigated the…
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Fluorescence Correlation Spectroscopy Measurements of the Membrane Protein TetA in Escherichia coli Suggest Rapid Diffusion at Short Length Scales
Structural inhomogeneities in biomembranes can lead to complex diffusive behavior of membrane proteins that depend on the length or time scales that are probed. This effect is well studied in eukaryotic cells, but has been explored only recently in bacteria. Here we used fluorescence recovery after…
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Isolation of Thylakoid Membrane Complexes from Rice by a New Double-Strips BN/SDS-PAGE and Bioinformatics Prediction of Stromal Ridge Subunits Interaction
Thylakoid membrane complexes of rice (Oryza sativa L.) play crucial roles in growth and crop production. Understanding of protein interactions within the complex would provide new insights into photosynthesis. Here, a new “Double-Strips BN/SDS-PAGE” method was employed to separate thylakoid…
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Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells
Transforming growth factor-β (TGF-β), via its receptors, induces epithelial-mesenchymal transition (EMT) and plays an important role in the development of renal tubulointersitial fibrosis. Angiotensin II type 2 receptor (AT2R), which mediates beneficial renal physiological functions, has received…
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Identification of Protein Network Alterations upon Retinal Ischemia-Reperfusion Injury by Quantitative Proteomics Using a Rattus norvegicus Model
Retinal ischemia is a common feature associated with several ocular diseases, including diabetic retinopathy. In this study, we investigated the effect of a retinal ischemia and reperfusion (I/R) injury on protein levels via a quantitative shotgun strategy using stable isotope dimethyl labeling…
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IFN-α as an Adjuvant for Adenovirus-Vectored FMDV Subunit Vaccine through Improving the Generation of T Follicular Helper Cells
IFN-α exhibits either direct antiviral effects or distinct immunomodulatory properties, which was identified as a ‘natural immune adjuvant’ for both the innate and the adaptive immune responses. Here we have investigated the effects of IFN-α as an adjuvant on the generation of T follicular helper…
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Identifying the Functional Flexion-extension Axis of the Knee: An In-Vivo Kinematics Study
Purpose: This study aimed to calculate the flexion-extension axis (FEA) of the knee through in-vivo knee kinematics data, and then compare it with two major anatomical axes of the femoral condyles: the transepicondylar axis (TEA) defined by connecting the medial sulcus and lateral prominence, and…
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The mechanism of seepage prevention of polymer grouting repair for longitudinal cracks in reconstructed and expanded pavement
A key challenge in highway reconstruction and expansion projects is to reduce longitudinal cracking at the junction of old and new roadbeds, which is a critical issue in the maintenance of transportation infrastructure. Polymer grouting technology, a non-excavation method for hidden subgrade…
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MSMCE: A novel representation module for classification of raw mass spectrometry data
Mass spectrometry (MS) analysis plays a crucial role in the biomedical field; however, the high dimensionality and complexity of MS data pose significant challenges for feature extraction and classification. Deep learning has become a dominant approach in data analysis, and while some deep learning…
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Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β 3 Subunit in Osteoblasts
Voltage-dependent L-type calcium channels that permit cellular calcium influx are essential in calcium-mediated modulation of cellular signaling. Although the regulation of voltage-dependent L-type calcium channels is linked to many factors including cAMP-dependent protein kinase A (PKA) activity…
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Lactate Dehydrogenase 5 Expression in Non-Hodgkin Lymphoma Is Associated with the Induced Hypoxia Regulated Protein and Poor Prognosis
Lactate dehydrogenase 5 (LDH-5) is one of the major isoenzymes catalyzing the biochemical process of pyruvate to lactate. The purpose of this study was to investigate the expression of serum LDH-5 and test whether this enzyme is regulated by tumor hypoxia and represents a prognostic marker in…
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Association between Endothelial Activation and Stress Index and mortality in diabetic nephropathy ICU patients: A retrospective cohort study
Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, often leading to poor outcomes in critically ill patients. Endothelial Activation and Stress Index (EASIX), a marker of endothelial dysfunction and systemic stress, has been associated with adverse outcomes in…
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Association between mean corpuscular volume and mortality in chronic kidney disease ICU patients: A retrospective multicenter cohort study
Background: Chronic kidney disease (CKD) affects over 10% of the global population and is closely linked to increased cardiovascular morbidity and mortality. Mean corpuscular volume (MCV), a key hematological parameter, has been associated with various clinical outcomes. However, the relationship…
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DNA Barcoding the Dioscorea in China, a Vital Group in the Evolution of Monocotyledon: Use of mat K Gene for Species Discrimination
Background: Dioscorea is an important plant genus in terms of food supply and pharmaceutical applications. However, its classification and identification are controversial. DNA barcoding is a recent aid to taxonomic identification and uses a short standardized DNA region to discriminate plant…
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Wnt/β-Catenin Signaling Regulates the Proliferation and Differentiation of Mesenchymal Progenitor Cells through the p53 Pathway
Objective: Mesenchymal progenitor cells (MPCs) are found in articular cartilage from normal controls and patients with osteoarthritis (OA). Nevertheless, the molecular mechanisms of the proliferation and differentiation of these cells remain unclear. In this study, we aimed to determine the…
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Higher Fibrinogen Level is Independently Linked with the Presence and Severity of New-Onset Coronary Atherosclerosis among Han Chinese Population
Background: Fibrinogen is a coagulation/inflammatory biomarker strongly associated with atherogenesis. However, no data is currently available regarding the association of fibrinogen level with the presence and severity of new-onset coronary atherosclerosis assessed by Gensini score (GS)…
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Hydrogen Sulfide Inhibits Transforming Growth Factor-β1-Induced EMT via Wnt/Catenin Pathway
Hydrogen sulfide (H2S) has anti-fibrotic potential in lung, kidney and other organs. The exogenous H2S is released from sodium hydrosulfide (NaHS) and can influence the renal fibrosis by blocking the differentiation of quiescent renal fibroblasts to myofibroblasts. But whether H2S affects renal…
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Association of leuko-glycemic index with mortality in ICU patients with Acute kidney injury: A retrospective multicenter cohort study
Background: Acute kidney injury (AKI) complicates the course of critical illness and carries high short- and long-term mortality rates; however, reliable early prognostic markers remain limited. The leuko-glycemic index (LGI), the product of white blood cell counts and blood glucose, has shown…
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A Predictive Model for Yeast Cell Polarization in Pheromone Gradients
Budding yeast cells exist in two mating types, a and α, which use peptide pheromones to communicate with each other during mating. Mating depends on the ability of cells to polarize up pheromone gradients, but cells also respond to spatially uniform fields of pheromone by polarizing along a single…