75 hasil untuk "Lin He"

Harvesting Candidate Genes Responsible for Serious Adverse Drug Reactions from a Chemical-Protein Interactome

Lun Yang; Jian Chen; Lin He

PLoS Computational Biology, Vol. 5 No. 7 · 2009 · Inggris · PLOS Scopus

Identifying genetic factors responsible for serious adverse drug reaction (SADR) is of critical importance to personalized medicine. However, genome-wide association studies are hampered due to the lack of case-control samples, and the selection of candidate genes is limited by the lack of…

A Novel Top- k Strategy for Influence Maximization in Complex Networks with Community Structure

Jia-Lin He; Yan Fu; Duan-Bing Chen

PLOS ONE, Vol. 10 No. 12 · 2015 · Inggris · PLOS Scopus

In complex networks, it is of great theoretical and practical significance to identify a set of critical spreaders which help to control the spreading process. Some classic methods are proposed to identify multiple spreaders. However, they sometimes have limitations for the networks with community…

Correction: A Novel Top- k Strategy for Influence Maximization in Complex Networks with Community Structure

Jia-Lin He; Yan Fu; Duan-Bing Chen

PLOS ONE, Vol. 11 No. 8 · 2016 · Inggris · PLOS Scopus

Urban–rural disparity in risky sexual behavior, HIV knowledge, and healthy practices among men who have sex with men: A cross-sectional study in Southeast China

Wanjun Chen; Lin Chen; Lin He dkk.

PLOS ONE, Vol. 19 No. 11 · 2024 · Inggris · PLOS Scopus

To identify differences in human immunodeficiency virus (HIV) risky behavior and healthy practices between rural and urban men who have sex with men (MSM) in Southeast China, a cross-sectional study was conducted on MSM aged ≥ 18 years recruited from four community-based organizations (CBOs) in…

The impact of household digital transformation on household energy efficiency: Empirical evidence from Chinese households

Suxu Lin; Lin He; Xin Lin dkk.

PLOS ONE, Vol. 19 No. 12 · 2024 · Inggris · PLOS Scopus

Carbon emissions from household consumption are an important part of global energy consumption, and household digital transformation is vital for realizing green and low−carbon development. Using data from the 2019 China Household Finance Survey, this study empirically examines the effect of…

Does Internet use alleviate household financial vulnerability? An empirical analysis based on panel data from China Family Panel Studies (CFPS)

Zeliang Yu; Heyu Li; Pei Guo dkk.

PLOS One, Vol. 21 No. 2 · 2026 · Inggris · PLOS Scopus

As digital technologies increasingly shape household financial behavior, understanding their role in buffering financial shocks has become an important policy and research concern. Drawing on panel data from the 2016, 2018, and 2020 waves of the China Family Panel Studies (CFPS), this paper…

Correlations between Community Structure and Link Formation in Complex Networks

Zhen Liu; Jia-Lin He; Komal Kapoor dkk.

PLoS ONE, Vol. 8 No. 9 · 2013 · Inggris · PLOS Scopus

Background: Links in complex networks commonly represent specific ties between pairs of nodes, such as protein-protein interactions in biological networks or friendships in social networks. However, understanding the mechanism of link formation in complex networks is a long standing challenge for…

Comparative Transcriptome Analysis of the Accessory Sex Gland and Testis from the Chinese Mitten Crab ( Eriocheir sinensis )

Lin He; Hui Jiang; Dandan Cao dkk.

PLoS ONE, Vol. 8 No. 1 · 2013 · Inggris · PLOS Scopus

The accessory sex gland (ASG) is an important component of the male reproductive system, which functions to enhance the fertility of spermatozoa during male reproduction. Certain proteins secreted by the ASG are known to bind to the spermatozoa membrane and affect its function. The ASG gene…

A Sparse Representation-Based Algorithm for Pattern Localization in Brain Imaging Data Analysis

Yuanqing Li; Jinyi Long; Lin He dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Considering the two-class classification problem in brain imaging data analysis, we propose a sparse representation-based multi-variate pattern analysis (MVPA) algorithm to localize brain activation patterns corresponding to different stimulus classes/brain states respectively. Feature selection…

Full length sequencing reveals novel transcripts of detoxification genes along with related alternative splicing events and lncRNAs in Phyllotreta striolata

Guang Mao Shen; Shi Yuan Ou; Chu He dkk.

PLOS ONE, Vol. 16 No. 3 · 2021 · Inggris · PLOS Scopus

The striped flea beetle, Phyllotreta striolata (Fabricius), damages crops in the Brassicaceae. The genetic data for this pest are insufficient to reveal its insecticide resistance mechanisms or to develop molecular markers for resistance monitoring. We used PacBio Iso-Seq technology to sequence the…

Identifying Unexpected Therapeutic Targets via Chemical-Protein Interactome

Lun Yang; Jian Chen; Leming Shi dkk.

PLoS ONE, Vol. 5 No. 3 · 2010 · Inggris · PLOS Scopus

Drug medications inevitably affect not only their intended protein targets but also other proteins as well. In this study we examined the hypothesis that drugs that share the same therapeutic effect also share a common therapeutic mechanism by targeting not only known drug targets, but also by…

Correction: Transcriptome Profiling of Testis during Sexual Maturation Stages in Eriocheir sinensis Using Illumina Sequencing

Lin He; Qun Wang; Xingkun Jin dkk.

PLoS ONE, Vol. 7 No. 8 · 2012 · Inggris · PLOS Scopus

Transcriptome Profiling of Testis during Sexual Maturation Stages in Eriocheir sinensis Using Illumina Sequencing

Lin He; Qun Wang; Xinkun Jin dkk.

PLoS ONE, Vol. 7 No. 3 · 2012 · Inggris · PLOS Scopus

The testis is a highly specialized tissue that plays dual roles in ensuring fertility by producing spermatozoa and hormones. Spermatogenesis is a complex process, resulting in the production of mature sperm from primordial germ cells. Significant structural and biochemical changes take place in the…

Evolutionary Adaptation of the Amino Acid and Codon Usage of the Mosquito Sodium Channel following Insecticide Selection in the Field Mosquitoes

Qiang Xu; Lee Zhang; Ting Li dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Target site insensitivity resulting from point mutations within the voltage-gated sodium channel of the insect nervous system is known to be of primary importance in the development of resistance to pyrethroid insecticides. This study shifts current research paradigms by conducting, for the first…

Sigma-1 Receptor Agonists Directly Inhibit Na V 1.2/1.4 Channels

Xiao-Fei Gao; Jin-Jing Yao; Yan-Lin He dkk.

PLoS ONE, Vol. 7 No. 11 · 2012 · Inggris · PLOS Scopus

(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K+, Na+ and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited NaV1.2 and…

Molecular Cloning and Gene Expression Analysis of the Leptin Receptor in the Chinese Mitten Crab Eriocheir sinensis

Hui Jiang; Fei Ren; Jiangling Sun dkk.

PLoS ONE, Vol. 5 No. 6 · 2010 · Inggris · PLOS Scopus

Background: Leptin is an adipocyte-derived hormone with multiple functions that regulates energy homeostasis and reproductive functions. Increased knowledge of leptin receptor function will enhance our understanding of the physiological roles of leptin in animals. Methodology/Principal Findings: In…

A Catalog of Proteins Expressed in the AG Secreted Fluid during the Mature Phase of the Chinese Mitten Crabs ( Eriocheir sinensis )

Lin He; Qing Li; Lihua Liu dkk.

PLOS ONE, Vol. 10 No. 8 · 2015 · Inggris · PLOS Scopus

The accessory gland (AG) is an important component of the male reproductive system of arthropods, its secretions enhance fertility, some AG proteins bind to the spermatozoa and affect its function and properties. Here we report the first comprehensive catalog of the AG secreted fluid during the…

Correlates of condom use among male university students from eastern China who engage in casual sex

Weiyong Chen; Xin Zhou; Qiaoqin Ma dkk.

PLOS ONE, Vol. 18 No. 5 · 2023 · Inggris · PLOS Scopus

Consistent condom use with casual partners is critical for preventing the transmission of human immunodeficiency virus (HIV) among male university students. This study aimed to determine the level of consistent condom use and explore the correlates of condom use consistency in male university…

Curcumin Ameliorates the Reduction Effect of PGE 2 on Fibrillar β-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells

Gen-Lin He; Zhen Luo; Ju Yang dkk.

PLOS ONE, Vol. 11 No. 1 · 2016 · Inggris · PLOS Scopus

Inflammatory activation of microglia and β amyloid (Aβ) deposition are considered to work both independently and synergistically to contribute to the increased risk of Alzheimer’s disease (AD). Recent studies indicate that long-term use of phenolic compounds provides protection against AD…

Involvement of Autophagy in Cardiac Remodeling in Transgenic Mice with Cardiac Specific Over-Expression of Human Programmed Cell Death 5

Lin An; Xiwen Zhao; Jian Wu dkk.

PLoS ONE, Vol. 7 No. 1 · 2012 · Inggris · PLOS Scopus

Programmed cell death 5 (PDCD5) is a cytosolic protein suppressing growth of multiple types of cancer cells through activating p53. We hypothesized that PDCD5 plays an essential role in cardiac remodeling and function. PDCD5 was significantly up-regulated in the hearts from mice subjected to…